LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation [0.03%]
长链非编码RNA LYPLAL1-AS1通过转录失活MIRLET7B来逆转人脂肪源性间充质干细胞衰老
Yanlei Yang,Suying Liu,Chengmei He et al.
Yanlei Yang et al.
Background: Mesenchymal stem cell (MSC) senescence is a phenotype of aging. Long noncoding RNAs (lncRNAs) are emerging as potential key regulators of senescence. However, the role of lncRNAs in MSC senescence remains larg...
Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design [0.03%]
伊莱胡斯病毒解旋酶的晶体结构及其对酶功能和药物设计的意义
De-Ping Wang,Mei-Yue Wang,Yong-Mei Li et al.
De-Ping Wang et al.
Background: The Ilheus virus (ILHV) is an encephalitis associated arthropod-borne flavivirus. It was first identified in Ilheus City in the northeast Brazil before spreading to a wider geographic range. No specific vaccin...
Rebuilding hippocampus neural circuit with hADSC-derived neuron cells for treating ischemic stroke [0.03%]
用于治疗缺血性卒中的源自人脂肪间充质干细胞的神经元细胞重建海马神经环路
Jian Wang,Rui Hao,Tianfang Jiang et al.
Jian Wang et al.
Background: Human adipose-derived stem cells (hADSCs) have been demonstrated to be a promising autologous stem cell source for treating various neuronal diseases. Our study indicated that hADSCs could be induced into neur...
PA1 participates in the maintenance of blood-testis barrier integrity via cooperation with JUN in the Sertoli cells of mice [0.03%]
PA1通过与小鼠支持细胞中JUN的合作参与维持血睾屏障的完整性
Bo Liu,Chao Liu,Binfang Ma et al.
Bo Liu et al.
Background: The blood-testis barrier (BTB) is essential to the microenvironment of spermatogenesis, and Sertoli cells provide the cellular basis for BTB construction. Numerous nuclear transcription factors have been ident...
UBIAD1 alleviates ferroptotic neuronal death by enhancing antioxidative capacity by cooperatively restoring impaired mitochondria and Golgi apparatus upon cerebral ischemic/reperfusion insult [0.03%]
UBIAD1通过协同修复脑缺血/再灌注损伤后受损的线粒体和高尔基复合体来增强抗氧化能力，从而缓解铁死亡介导的神经元死亡
Yan Huang,Jianyang Liu,Jialin He et al.
Yan Huang et al.
Background: Neuronal death due to over-oxidative stress responses defines the pathology of cerebral ischemic/reperfusion (I/R) insult. Ferroptosis is a form of oxidative cell death that is induced by disruption of the bal...
Giovanna M Bernal,Longtao Wu,David J Voce et al.
Giovanna M Bernal et al.
Background: Nuclear factor-κB is a multi-subunit transcription factor that plays a central role in cellular senescence. We previously reported that an increase in the p52 subunit is seen in senescent cells and aged tissu...
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer [0.03%]
三维和类器官培养在研究中的应用：生理学、遗传性基因疾病与癌症研究
Elisa Suarez-Martinez,Irene Suazo-Sanchez,Manuel Celis-Romero et al.
Elisa Suarez-Martinez et al.
In nature, cells reside in tissues subject to complex cell-cell interactions, signals from extracellular molecules and niche soluble and mechanical signaling. These microenvironment interactions are responsible for cellular phenotypes and f...
MIR210HG promotes breast cancer progression by IGF2BP1 mediated m6A modification [0.03%]
MIR210HG通过IGF2BP1介导的m6A修饰促进乳腺癌进展
Wenjing Shi,Yongzhe Tang,Jing Lu et al.
Wenjing Shi et al.
Background: Breast cancer is the most common cancer in women around the world, and the molecular mechanisms of breast cancer progression and metastasis are still unclear. This study aims to clarify the function and N6,2'-...
DNA in extracellular vesicles: from evolution to its current application in health and disease [0.03%]
细胞外囊泡中的DNA：从进化到其在健康和疾病领域的当前应用
Jamal Ghanam,Venkatesh Kumar Chetty,Lennart Barthel et al.
Jamal Ghanam et al.
Extracellular vesicle (EV) secretion is a highly conserved evolutionary trait in all organisms in the three domains of life. The packaging and release of EVs appears to be a bulk-flow process which takes place mainly under extreme condition...
SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1 [0.03%]
SARS-CoV-2 NSP13解旋酶通过干扰JAK1介导的STAT1磷酸化来抑制I型干扰素信号通路
Sin-Yee Fung,Kam-Leung Siu,Huayue Lin et al.
Sin-Yee Fung et al.
Background: SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of this condition with JAK inhibitors is a double-e...