TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling [0.03%]
TRPM8缺乏通过S100A9-HNF4α信号转导减弱肝纤维化
Qiang Liu,Xiaohua Lei,Zhenyu Cao et al.
Qiang Liu et al.
Background: Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, a member of the transient receptor potential (TRP) family of ion channels, plays an essential role ...
AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology [0.03%]
中枢神经系统AKT抑制引起信号缺陷导致精神症状群
Apostolia-Maria Tsimberidou,Antonis Skliris,Alan Valentine et al.
Apostolia-Maria Tsimberidou et al.
Background: Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. ...
VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells [0.03%]
VHL Ser65突变增强HIF2α信号传导并促进肾癌细胞的上皮间质转化
Xueyou Ma,Zenglai Tan,Qin Zhang et al.
Xueyou Ma et al.
Background: Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or mali...
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma [0.03%]
Rho家族GTP酶1(RND1)，一种新的p53调节因子，可增强胶质母细胞瘤中的铁死亡
Qian Sun,Yang Xu,Fan&#x;en Yuan et al.
Qian Sun et al.
Background: Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and is aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration. Identifying new...
Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions [0.03%]
间充质干细胞来源的细胞外囊泡异质性受组织/细胞种类和培养条件的影响较大
Ciarra Almeria,Sebastian Kreß,Viktoria Weber et al.
Ciarra Almeria et al.
Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in physiological as well as pathological processes by functioning as vehicles for the delivery of biomolecules to their target cells. An increasing num...
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy [0.03%]
PTEN突变的非小细胞肺癌需要ATM来抑制促凋亡信号并逃避放疗
Thomas Fischer,Oliver Hartmann,Michaela Reissland et al.
Thomas Fischer et al.
Background: Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These ...
Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma [0.03%]
组蛋白甲基转移酶KMT2D与MEF2A协作促进口腔鳞状细胞癌干细胞样特性的发展
Xinmiao Wang,Rui Li,Luping Wu et al.
Xinmiao Wang et al.
Background: Epigenetic reprogramming is involved in multiple steps of human cancer evolution and is mediated by a variety of chromatin-modifying enzymes. Specifically, the histone lysine methyltransferase KMT2D is among t...
Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors [0.03%]
药理学激活ATF6重塑蛋白质稳态网络以抢救致病性GABA受体
Meng Wang,Edmund Cotter,Ya-Juan Wang et al.
Meng Wang et al.
Background: Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that path...
MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway [0.03%]
MLL-AF4及其鼠源性pSer突变体能够激活核仁应激途径
Anna Lena Siemund,Thomas Hanewald,Eric Kowarz et al.
Anna Lena Siemund et al.
Background: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoiet...
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation [0.03%]
活化芳香烃受体通过调节耐受性树突细胞和调节性T细胞的形成缓解实验性结肠炎
Xiufang Cui,Ziping Ye,Di Wang et al.
Xiufang Cui et al.
Background: Intestinal immune dysfunction is involved in the onset of Crohn's disease (CD). Dendritic cells (DCs), antigen-presenting cells, play a key role in the maintenance of intestinal immune homeostasis. The aryl hy...