Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases [0.03%]
线粒体转移/移植：一种新兴的疾病治疗策略
Zonghan Liu,Yi Sun,Zhengtang Qi et al.
Zonghan Liu et al.
Mitochondria play a pivotal role in energy generation and cellular physiological processes. These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in response to cellular stress. In re...
Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition [0.03%]
单个人胎盘绒毛膜滋养细胞和合体滋养细胞的核糖体蛋白质合成异质性
Wang-Sheng Wang,Yi-Kai Lin,Fan Zhang et al.
Wang-Sheng Wang et al.
Background: The human amnion is an intrauterine tissue which is involved in the initiation of parturition. In-depth understanding of gene expression signatures of individual cell types in the amnion with respect to membra...
Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants [0.03%]
抗体工程改善了针对SARS-CoV-2 K417刺突变异株的中和活性
Lili Li,Meiling Gao,Peng Jiao et al.
Lili Li et al.
Background: Neutralizing antibodies are approved drugs to treat coronavirus disease-2019 (COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants may reduce the antibody ne...
Nanotechnological engineering of extracellular vesicles for the development of actively targeted hybrid nanodevices [0.03%]
纳米工程技术在外泌体工程中的应用及靶向杂化纳米器件的开发研究
Bianca Dumontel,Francesca Susa,Tania Limongi et al.
Bianca Dumontel et al.
Background: We propose an efficient method to modify B-cell derived EVs by loading them with a nanotherapeutic stimuli-responsive cargo and equipping them with antibodies for efficient targeting of lymphoma cells. ...
RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence [0.03%]
RNA测序谱型揭示骨髓间充质干细胞衰老过程中的动态信号和葡萄糖代谢特征
Yanan Sun,Xiao Yu,Xingyu Gao et al.
Yanan Sun et al.
Background: Stem cell senescence is considered as a significant driver of organismal aging. As individuals age, the number of stem cells is declined, and the ability to proliferate and survive is also weakened. It has bee...
m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer [0.03%]
FTO通过调节脂质代谢促进食管癌肿瘤进展
Xiaoran Duan,Li Yang,Liuya Wang et al.
Xiaoran Duan et al.
Background: Epitranscriptomics studies have contributed greatly to the development of research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA modification on the N-6 position of adenosine, has been fo...
Analysis of CCR2 splice variant expression patterns and functional properties [0.03%]
CCR2剪接变异体的表达模式和功能属性分析
Hee-Kyung Park,Yun Hee Na,Huong Thi Nguyen et al.
Hee-Kyung Park et al.
Background: C-C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells, including monocytes, macrophages, and activated T cells, and mediates cell...
LRP4 is required for the olfactory association task in the piriform cortex [0.03%]
LRP4是梨状皮层嗅觉相关任务所需的一种蛋白
Min Yan,Mingtao Xiong,Yongqiang Wu et al.
Min Yan et al.
Background: Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, ...
Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire [0.03%]
单细胞基因组学鉴定出独特的B1细胞发育途径并揭示了B细胞受体在衰老过程中的变化
Yao Luo,Jing Wang,Kairui Li et al.
Yao Luo et al.
Background: B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from various fetal t...
PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner [0.03%]
PA2G4通过依赖YTHDF2的方式稳定FYN mRNA促进肝细胞癌转移
Sheng Sun,Yiyang Liu,Meiling Zhou et al.
Sheng Sun et al.
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high mortality. Advanced stage upon diagnosis and cancer metastasis are the main reasons for the dismal prognosis of HCC in large...