Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans [0.03%]
骨形态发生蛋白信号调节肺肿瘤细胞及线虫中的AMPK和PI3K
Mehul Vora,Arindam Mondal,Dongxuan Jia et al.
Mehul Vora et al.
Background: Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer's disease, o...
A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector [0.03%]
一个最小胆盐排泄泵启动子允许胆酸驱动的治疗基因表达的生理调节
Javier Martínez-García,Manuela Molina,Leticia Odriozola et al.
Javier Martínez-García et al.
Background: Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile. BSEP expression is regulated by BA levels through activation of farne...
The two-faced role of ATF2 on cisplatin response in gastric cancer depends on p53 context [0.03%]
ATF2在胃癌顺铂反应中的双重作用取决于p53背景环境
Lingxue Xu,Jingjing Wang,Danhua Zhang et al.
Lingxue Xu et al.
Background: Activating transcription factor-2 (ATF2) is a member of the basic leucine zipper family of DNA-binding proteins, which exhibits both oncogenic and tumor suppression activity in different tumors. However, the m...
Fibronectin extra domain A (FN-EDA) causes glaucomatous trabecular meshwork, retina, and optic nerve damage in mice [0.03%]
纤维连接蛋白额外域A(FN-EDA)导致小鼠房角、视网膜和视神经的青光眼病变
Timur A Mavlyutov,Justin J Myrah,Anil K Chauhan et al.
Timur A Mavlyutov et al.
Background: Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage. Here, we investigate the role of an ...
Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases [0.03%]
靶向先天免疫传感器治疗自身免疫病的应用和前景
Jun Liu,Hui Zhang,Yanhong Su et al.
Jun Liu et al.
Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive inflammation are responsible for the occurrence and development of autoimmune diseases. The suppression of autoreactive T cell activation and autoantibo...
The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis [0.03%]
腹内侧下丘脑核：全身葡萄糖稳态的监视者
Longlong Tu,Makoto Fukuda,Qingchun Tong et al.
Longlong Tu et al.
The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is still not fully understood how the brain detects and responds...
β-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood-brain barrier destruction in Alzheimer's disease [0.03%]
β淀粉样蛋白通过CD36/PINK/Parkin途径诱导线粒体自噬依赖性铁死亡导致阿尔茨海默病中血脑屏障破坏
Jianhua Li,Mengyu Li,Yangyang Ge et al.
Jianhua Li et al.
Introduction: Blood-brain barrier (BBB) dysfunction may occur at the onset of Alzheimer's disease (AD). Pericytes are a vital part of the neurovascular unit and the BBB, acting as gatekeepers of the BBB. Amyloid β (Aβ) ...
BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1 [0.03%]
BHLHE40通过c-Fos/NFATc1促进破骨细胞生成和异常骨吸收
Yufeng Zhang,Min Yang,Sheng Zhang et al.
Yufeng Zhang et al.
Background: Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role ...
Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation [0.03%]
近期Treg细胞来源的外泌体免疫调节作用的研究亮点：重点关注自身免疫病和移植
Yahya Asemani,Sajad Najafi,Fatemeh Ezzatifar et al.
Yahya Asemani et al.
In order to maintain immunological tolerance to self and non-self antigens, one's T regulatory (Treg) cells play a critical role in the regulation of detrimental inflammation. Treg cells inhibit the immune system in a variety of ways, some ...
Ginkgolic acid and anacardic acid are reversible inhibitors of SARS-CoV-2 3-chymotrypsin-like protease [0.03%]
银杏酸和山毛榉酸是SARS-CoV-2 3-胰凝乳蛋白酶样蛋白酶的可逆抑制剂
Dongsheng Li,Gangan Yan,Wenwen Zhou et al.
Dongsheng Li et al.
Because of the emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different regions of the world, the battle with infectious coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been seesawing. Ther...