Mengjun Li,Linye He,Jing Zhu et al.
Mengjun Li et al.
Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30-50% of stromal cells in the tumor microenvironment. TAMs exhibit an immunosuppressive M2-like phenotype in advanced cancer, which plays a crucial role in tumor growt...
Hepatitis, testicular degeneration, and ataxia in DIDO3-deficient mice with altered mRNA processing [0.03%]
DIDO3缺陷小鼠中改变的mRNA剪接导致肝炎、睾丸退化和共济失调
Julio Gutiérrez,Karel H M van Wely,Carlos Martínez-A
Julio Gutiérrez
Background: mRNA processing is an essential step of gene expression; its malfunction can lead to different degrees of physiological disorder from subclinical disease to death. We previously identified Dido1 as a stemness ...
Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney [0.03%]
空间转录组与单细胞转录组建模揭示了人类肾脏发育的时空基因图谱
Hongwei Wu,Fanna Liu,Yu Shangguan et al.
Hongwei Wu et al.
Background: Research on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate kidney organoid cultivation. Here, we profiled the spatiotemporal gene...
The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes [0.03%]
转录调控中的磷酸化到乙酰化/甲基化级联反应：蛋白激酶如何调节DNA/组蛋白修饰酶的转录活性
Pin Zhao,Samiullah Malik
Pin Zhao
Transcription factors directly regulate gene expression by recognizing and binding to specific DNA sequences, involving the dynamic alterations of chromatin structure and the formation of a complex with different kinds of cofactors, like DN...
FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion [0.03%]
FANCC缺陷介导脊髓挫伤后的小胶质细胞焦亡及继发性神经元凋亡
Mingjie Xia,Xinyu Li,Suhui Ye et al.
Mingjie Xia et al.
Background: Traumatic spinal cord injury (SCI)-induced neuroinflammation results in secondary neurological destruction and functional disorder. Previous findings showed that microglial pyroptosis plays a crucial role in n...
Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection [0.03%]
组蛋白去乙酰酶3通过抑制CTS B诱导的RIP1降解促进TNFα介导的NF-κB活化并在细菌感染抗性中必不可少
Liping Yang,Shengchuan Chen,Jingyan Xia et al.
Liping Yang et al.
Background: As important enzymes regulating acetylation, histone deacetylases (HDACs) participate in a series of cell physiological process. However, the mechanisms responsible for individual HDAC family members in regula...
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities [0.03%]
衰老相关分泌表型(SASP)在动脉粥样硬化中的作用及转化治疗策略展望：从机制探索到临床应用
Yu Sun,Xia Wang,Tianwei Liu et al.
Yu Sun et al.
Background: The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious ef...
Mosaic loss of chromosome Y in peripheral blood cells is associated with age-related macular degeneration in men [0.03%]
外周血细胞中Y染色体丢失与男性年龄相关性黄斑变性疾病有关
Qinchun Duan,Yuru Gao,Xixi Cao et al.
Qinchun Duan et al.
Background: Age-related macular degeneration (AMD) is the leading cause of severe vision loss in patients over 55 years old in the industrialized world. In the past 20 years, approximately 288 million patents have been af...
Mxc, a Drosophila homolog of mental retardation-associated gene NPAT, maintains neural stem cell fate [0.03%]
果蝇精神分裂症相关基因NPAT同源基因Mxc维持神经干细胞命运
Rong Sang,Cheng Wu,Shanshan Xie et al.
Rong Sang et al.
Background: Mental retardation is a complex neurodevelopmental disorder. NPAT, a component of the histone locus body (HLB), has been implicated as a candidate gene for mental retardation, with a mechanism yet to be elucid...
Host-dependent impairment of parasite development and reproduction in the acanthocephalan model [0.03%]
宿主依赖的旋毛纲模型寄生虫发育和繁殖的缺陷
Hanno Schmidt,Katharina Mauer,Thomas Hankeln et al.
Hanno Schmidt et al.
Background: A central question in parasitology is why parasites mature and reproduce in some host species but not in others. Yet, a better understanding of the inability of parasites to complete their life cycles in less ...