Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases [0.03%]
神经胶质细胞中的脂代谢与储存：在脑发育和神经退行性疾病中的作用
Danying Yang,Xifeng Wang,Lieliang Zhang et al.
Danying Yang et al.
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years. The most important issues regarding glial metabolism and function inclu...
Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis [0.03%]
扩大CRISPR/Cas在热带非洲爪蟾基因组编辑中的应用范围
Zhaoying Shi,Hao Jiang,Guanghui Liu et al.
Zhaoying Shi et al.
Background: The true diploid frog, Xenopus tropicalis (X. tropicalis) is an excellent genetic model organism. To date, the CRISPR/Cas-mediated genome editing methods established in this species are mostly based on SpCas9 ...
Metabolomics of blood reveals age-dependent pathways in Parkinson's Disease [0.03%]
基于血液的代谢组学发现帕金森病中年龄依赖性通路
Nicola D&#x;Ascenzo,Emanuele Antonecchia,Antonella Angiolillo et al.
Nicola D&#x;Ascenzo et al.
Background: Parkinson's Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic...
Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function [0.03%]
神经病相关的Fars2缺乏影响神经元发育并通过损害线粒体功能增强神经元凋亡
Xihui Chen,Fangfang Liu,Bowen Li et al.
Xihui Chen et al.
Background: Neurodegenerative diseases encompass an extensive and heterogeneous group of nervous system disorders which are characterized by progressive degeneration and death of neurons. Many lines of evidence suggest th...
Advancing equity through strengthening research on health and well-being of Asian American, Native Hawaiian, and Pacific Islander [0.03%]
通过加强亚裔美国人、夏威夷原住民和太平洋岛民健康与福祉的研究来推进公平性
Dan Xi,Ming Lei,Paul Liu et al.
Dan Xi et al.
The National Institutes of Health's Asian American, Native Hawaiian and Pacific Islander Health Scientific Interest Group (NIH AANHPI-HSIG) provides a viewpoint on developing approaches to enhance research on health and wellbeing for Asian ...
Editorial Expression of Concern: Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway [0.03%]
编辑部关注函：吉客糖通过抑制NF-κB信号通路激活SIRT1缓解脂多糖诱导的急性肾损伤
Junwei Zhang,Suxia Yang,Fang Chen et al.
Junwei Zhang et al.
DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis [0.03%]
DNA甲基转移酶1敲低通过介导启动子去甲基化改善乙型肝炎病毒相关性肾小球肾炎所致的肾脏损伤
Haochen Guan,Nan Zhu,Gang Tang et al.
Haochen Guan et al.
Background: Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DN...
Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation [0.03%]
非酒精性脂肪肝病与痴呆症的新见解：胰岛素抵抗、血氨升高、肠道菌群失调、血管功能障碍和炎症
So Yeong Cheon,Juhyun Song
So Yeong Cheon
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple pathologies. The progression of dementia with NAFLD may be affected by various risk factors, including brain insulin resistance, cerebrovascular dysf...
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star [0.03%]
圆形RNA在胰腺癌中的生物学功能、机制及临床意义：一颗值得期待的新星
Qun Chen,Jiajia Li,Peng Shen et al.
Qun Chen et al.
Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear...
Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate [0.03%]
酮体(D)-3-羟基丁酸通过减少肌肉萎缩的机制
Jin Chen,Zihua Li,Yudian Zhang et al.
Jin Chen et al.
Background: Muscle atrophy is an increasingly global health problem affecting millions, there is a lack of clinical drugs or effective therapy. Excessive loss of muscle mass is the typical characteristic of muscle atrophy...