Myometrial oxidative stress drives MED12 mutations in leiomyoma [0.03%]
子宫平滑肌氧化应激通过MED12突变驱动子宫平滑肌瘤发生发展
Yinuo Li,Xiuhua Xu,Huma Asif et al.
Yinuo Li et al.
Background: More than 70% of leiomyomas (LM) harbor MED12 mutations, primarily in exon 2 at c.130-131(GG). The cause of MED12 mutations in myometrial cells remains largely unknown. We hypothesized that increased ROS promo...
Single-cell RNA sequencing reveals the potential mechanism of heterogeneity of immunomodulatory properties of foreskin and umbilical cord mesenchymal stromal cells [0.03%]
单细胞RNA测序揭示了皮肤和脐带间充质干细胞免疫调节特性的异质性潜在机制
Siyu Cai,Chuiqin Fan,Lichun Xie et al.
Siyu Cai et al.
Background: Mesenchymal stromal cells (MSCs) are heterogeneous populations. Heterogeneity exists within the same tissue and between different tissues. Some studies have found enormous heterogeneity in immunomodulatory fun...
Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis [0.03%]
中性粒细胞胞外陷阱在脑静脉窦血栓形成中的促凝作用
Jiaqi Jin,Shan Qiao,Jie Liu et al.
Jiaqi Jin et al.
Background: Neutrophil extracellular traps (NETs) contribute to the creation of a coagulation state in various diseases. Currently, it is not clear whether NETs are present in the thrombi and plasma of patients with cereb...
SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia-reperfusion injury [0.03%]
SENP6通过诱导脑缺血再灌注损伤后 Annexin-A1 的去SUMO化促进小胶质细胞极化和神经炎症
Meng Mao,Qian Xia,Gao-Feng Zhan et al.
Meng Mao et al.
Background: Previous data have reported that Sentrin/SUMO-specific protease 6 (SENP6) is involved in ischaemic brain injury and induces neuronal apoptosis after cerebral ischaemia, but the role of SENP6 in microglia-induc...
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia [0.03%]
FBXL17/spastin轴作为遗传性痉挛性截瘫的新治疗靶点
Hyun Mi Kang,Dae Hun Kim,Mijin Kim et al.
Hyun Mi Kang et al.
Background: Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein re...
Regulatory T cells-centered regulatory networks of skeletal muscle inflammation and regeneration [0.03%]
肌炎与再生相关的调节性T细胞中心调控网络
Ziyu Chen,HaiQiang Lan,ZhaoHong Liao et al.
Ziyu Chen et al.
As the understanding of skeletal muscle inflammation is increasingly clarified, the role of Treg cells in the treatment of skeletal muscle diseases has attracted more attention in recent years. A consensus has been reached that the regulati...
Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial-mesenchymal transition and Beclin-1/ATG14 pathway [0.03%]
Siglec-15诱导的自噬通过激活上皮间质转化和Beclin-1/ATG14通路促进人成骨肉瘤细胞侵袭转移
Bingxin Zheng,Keliang Song,Lingling Sun et al.
Bingxin Zheng et al.
Background: Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in os...
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose [0.03%]
由钙调神经磷酸酶Ⅱ-蛋白酶体轴调控的NF-κB促炎新途径参与高糖早期激活 Müller细胞活化
Diego Sbardella,Grazia Raffaella Tundo,Alice Mecchia et al.
Diego Sbardella et al.
Background: Diabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a dramatic burden for health and economic systems on a global scale. Althou...
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy [0.03%]
人皮肤真皮成纤维细胞是一种具有功能的间充质基质细胞：基于表面标志物、生物学特性及治疗效果的判断
Chenxu Tai,Zhengyao Xie,Yu Li et al.
Chenxu Tai et al.
Background: Human mesenchymal stromal cells (MSCs) have been widely advocated to clinical use. Human skin dermis-derived fibroblasts shared similar cellular morphology and biological characteristics to MSCs, while it stil...
Transcriptomic analysis reveals the key role of histone deacetylation via mediating different phytohormone signalings in fiber initiation of cotton [0.03%]
转录组分析揭示组蛋白去乙酰化通过介导不同植物激素信号转导在棉纤维起始中的关键作用
Zhenzhen Wei,Yonghui Li,Faiza Ali et al.
Zhenzhen Wei et al.
Background: Histone deacetylation is one of the most important epigenetic modifications and plays diverse roles in plant development. However, the detailed functions and mechanisms of histone deacetylation in fiber develo...