N6-methyladenosine-mediated CELF2 regulates CD44 alternative splicing affecting tumorigenesis via ERAD pathway in pancreatic cancer [0.03%]
N6-甲基腺苷介导的CELF2通过胰腺癌中的ERAD途径调节CD44的可变剪接从而影响肿瘤发生
Shihui Lai,Yan Wang,Ting Li et al.
Shihui Lai et al.
Background: Alternative splicing (AS) of genes has been found to affect gene stability, and its abnormal regulation can lead to tumorigenesis. CELF2 is a vital splicing factor to participate in mRNA alternative splicing. ...
IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis [0.03%]
IFITM3通过靶向MET/AKT/FOXO3/c-MYC轴促进胃癌的恶性进展、癌症干细胞特性和化学抗性
Pei-Yi Chu,Wei-Chieh Huang,Shiao-Lin Tung et al.
Pei-Yi Chu et al.
Background: Targeting the HGF/MET signaling pathway has been a viable therapeutic strategy for various cancer types due to hyperactivation of HGF/MET axis occurs frequently that leads to detrimental cancer progression and...
GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis [0.03%]
异质性成纤维细胞中GREM1 / PPP2R3A的表达启动肺纤维化
Xiaoni Shi,Jing Wang,Xinxin Zhang et al.
Xiaoni Shi et al.
Background: Fibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal distribution of heterogeneous fibroblasts during d...
AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer [0.03%]
AKT磷酸化作为预测生物标志物用于PI3K/mTOR双重抑制诱导的小细胞肺癌中mTOR伴侣蛋白的蛋白水解切割事件
Ming-Chun Hung,Wan-Ping Wang,Ya-Hui Chi
Ming-Chun Hung
Background: Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has the most aggressive clinical course amongst pulmonary tumors. Whereas ...
Tick-borne encephalitis affects sleep-wake behavior and locomotion in infant rats [0.03%]
蜱传脑炎影响婴儿大鼠的睡眠-觉醒行为和运动功能
Gabriele Chiffi,Denis Grandgirard,Sabrina Stöckli et al.
Gabriele Chiffi et al.
Background/aims: Tick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has steadily increased in Europe and Asia despite the availably of effective vac...
Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer [0.03%]
新型衍生齐多夫定类似物Oxy186和Oxy210通过抑制非小细胞肺癌的Wnt信号通路发挥其抗肿瘤活性
Liu-Ya Tang,Marie Spezia,Ting Chen et al.
Liu-Ya Tang et al.
Background: Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation. They are often constitutively activated in many hum...
LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer [0.03%]
长链非编码RNA CRLM1通过与hnRNPK转录调控合作抑制结直肠癌细胞凋亡并促进转移
Zhe Wang,Jianfang Chen,Fengjun Sun et al.
Zhe Wang et al.
Background: Colorectal liver metastases (CRLM) continue to have a low survival rate. The number of CRLM regulators and clinical indicators remains limited. Long non-coding RNAs (lncRNAs) are a new master regulator of cell...
Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting [0.03%]
孤束核弓形AgRP但不是POMC神经元调节禁食引起的视上核CRF合成和释放
Alan Carlos Alves Fernandes,Franciane Pereira de Oliveira,Gimena Fernandez et al.
Alan Carlos Alves Fernandes et al.
Background: The activation of the hypothalamic-pituitary-adrenal (HPA) axis is essential for metabolic adaptation in response to fasting. However, the neurocircuitry connecting changes in the peripheral energy stores to t...
New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction [0.03%]
从细胞外基质降解角度研究纤维化的新见解——巨噬细胞-基质金属蛋白酶-细胞外基质的相互作用
Xiangyu Zhao,Jiayin Chen,Hongxiang Sun et al.
Xiangyu Zhao et al.
Fibrosis is a pathological feature of a variety of chronic inflammatory diseases that can affect almost all organs, which can cause severe consequences and even lead to death. Fibrosis is characterized by the excessive accumulation of extra...
cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium [0.03%]
cGAS抑制缓解视网膜色素上皮中Alu RNA诱导的免疫反应和细胞毒性
Jing Li,Feng Zhang,Wei Bian et al.
Jing Li et al.
Background: The degeneration of retinal pigmented epithelium (RPE) cells results in severe diseases, such as age-related macular degeneration (AMD) that causes blindness in millions of individuals. ...