Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer [0.03%]
CUDC-907通过激活ROS-IRE1α-JNK介导的细胞毒性和自噬作用抑制食管癌肿瘤的作用效果研究
Zheng Jian,Yichao Han,Wentian Zhang et al.
Zheng Jian et al.
Background: PI3K-Akt pathway activation and the expression of histone deacetylases (HDACs) are highly increased in esophageal cancer, suggesting that inhibition of such targets may be a viable therapeutic strategy. Herein...
Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling [0.03%]
褪黑素通过抑制HIF-1α/Bnip3-LC3B线粒体自噬信号通路对抗NaIO3致ARPE-19细胞凋亡的作用研究
Kai Wang,Yong-Syuan Chen,Hsiang-Wen Chien et al.
Kai Wang et al.
Background: Age-related macular degeneration (AMD) leads to gradual central vision loss and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti-inflammatory and antitumor effects; however, the...
Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction [0.03%]
特异性抑制心脏成纤维细胞富集的组蛋白甲基转移酶Dot1L防治心肌纤维化及心室重构
Jie Xu,Jinghuan Wang,Fen Long et al.
Jie Xu et al.
Background: Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is...
Urological cancer organoids, patients' avatars for precision medicine: past, present and future [0.03%]
泌尿系肿瘤类器官：精准医学患者的替身模型：过去、现在和未来
Haotian Chen,Wentao Zhang,Niraj Maskey et al.
Haotian Chen et al.
Urological cancers are common malignant cancers worldwide, with annually increasing morbidity and mortality rates. For decades, two-dimensional cell cultures and animal models have been widely used to study the development and underlying mo...
Functions and mechanisms of protein disulfide isomerase family in cancer emergence [0.03%]
蛋白质二硫异构酶家族在癌症发生中的功能和机制
Nisa Syakila A Rahman,Syazalina Zahari,Saiful Effendi Syafruddin et al.
Nisa Syakila A Rahman et al.
The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome. It houses several resident proteins for these functions includ...
OpenVar: functional annotation of variants in non-canonical open reading frames [0.03%]
OpenVar：非规范开放阅读框内变异的功能注释
Marie A Brunet,Sébastien Leblanc,Xavier Roucou
Marie A Brunet
Background: Recent technological advances have revealed thousands of functional open reading frames (ORF) that have eluded reference genome annotations. These overlooked ORFs are found throughout the genome, in any readin...
Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway [0.03%]
早老素1突变通过Akt/mTORC1信号通路诱导人源神经元tau蛋白聚集
Cheong-Meng Chong,Yuan Tan,Jiaqi Tong et al.
Cheong-Meng Chong et al.
Background: The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer's disease (AD). Presenilin-1 (PS1) mutations account f...
Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling [0.03%]
破骨细胞源性外泌体通过激活表皮生长因子信号促进感觉神经纤维侧支再生
Estrela Neto,Luís Leitão,José C Mateus et al.
Estrela Neto et al.
Background: Different pathologies, affecting the skeletal system, were reported to display altered bone and/or cartilage innervation profiles leading to the deregulation of the tissue homeostasis. The patterning of periph...
D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury [0.03%]
D-多巴胺酮互变异构酶通过NF-κB信号在脊髓损伤后驱动星形胶质细胞炎症反应
Hui Li,Bingqiang He,Xingyuan Zhang et al.
Hui Li et al.
Background: Reactive astrocytes are increasingly recognized as crucial regulators of innate immunity in degenerative or damaged central nervous system (CNS). Many proinflammatory mediators have been shown to drive inflamm...
Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture [0.03%]
蛋白质泛素化表征的当前方法学：从泛素化蛋白到泛素链结构
Mingwei Sun,Xiaofei Zhang
Mingwei Sun
Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization. Unsurprisingly, dysregulation of the complex interacti...