Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation [0.03%]
宫内炎症暴露的新生儿发生肺损伤介导因素Serpine1甲基化异常
Dongting Yao,Jiuru Zhao,Qianqian Zhang et al.
Dongting Yao et al.
Background: Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present stud...
Revisiting potential value of antitumor drugs in the treatment of COVID-19 [0.03%]
抗肿瘤药物治疗COVID-19的潜在价值再评估
Wenfang Zheng,Zekun Zeng,Shumei Lin et al.
Wenfang Zheng et al.
Since an outbreak started in China in 2019, coronavirus disease 2019 (COVID-19) has rapidly become a worldwide epidemic with high contagiousness and caused mass mortalities of infected cases around the world. Currently, available treatments...
YAP1 protects against septic liver injury via ferroptosis resistance [0.03%]
YAP1通过铁死亡抵抗保护机体免受脓毒症引起的肝损伤
Jin Wang,Qian Zhu,Rui Li et al.
Jin Wang et al.
Background: The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure. ...
A change of PD-1/PD-L1 expression on peripheral T cell subsets correlates with the different stages of Alzheimer's Disease [0.03%]
PD-1/PD-L1在周边T细胞亚群中的表达变化与阿尔茨海默病的不同阶段相关联
Ching-Tse Wu,Cheng-I Chu,Feng-Yu Wang et al.
Ching-Tse Wu et al.
Background: Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune homeostasis. The expression of immune checkpoints on T cells in malignancy, chronic infla...
Correction to: Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney [0.03%]
对整合空间转录组学与单细胞转录组学揭示人类肾脏发育时空基因图谱的修正
Hongwei Wu,Fanna Liu,Yu Shangguan et al.
Hongwei Wu et al.
Published Erratum
Cell & bioscience. 2022 Sep 25;12(1):161. DOI:10.1186/s13578-022-00878-4 2022
Alina Meeser,Christoph Bartenhagen,Lisa Werr et al.
Alina Meeser et al.
Background: Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by activation of telomerase or alternative lengthening of telomeres (ALT). However, detection of TMM is not ye...
Modeling lung diseases using reversibly immortalized mouse pulmonary alveolar type 2 cells (imPAC2) [0.03%]
利用可逆永生化的鼠肺泡Ⅱ型细胞系(imPAC2)建立肺部疾病模型
Linghuan Zhang,Wenping Luo,Jiang Liu et al.
Linghuan Zhang et al.
Background: A healthy alveolar epithelium is critical to the gas exchange function of the lungs. As the major cell type of alveolar epithelium, alveolar type 2 (AT2) cells play a critical role in maintaining pulmonary hom...
Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma [0.03%]
神经母细胞瘤中超增强子相关的INSM2通过调节mTOR信号通路调控脂质代谢
Haibo Cao,Ran Zhuo,Zimu Zhang et al.
Haibo Cao et al.
Background: Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insul...
Jörg Wilting,Jürgen Becker
Jörg Wilting
Almost 400 years after the (re)discovery of the lymphatic vascular system (LVS) by Gaspare Aselli (Asellius G. De lactibus, sive lacteis venis, quarto vasorum mesaraicorum genere, novo invento Gasparis Asellii Cremo. Dissertatio. (MDCXXIIX)...
PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders [0.03%]
外周手术刺激诱发中枢小胶质细胞PEX5R/Trip8b-HCN2通道激活介导术后神经认知障碍发生发展的作用及机制研究
Feng Xu,Yafeng Wang,Linlin Han et al.
Feng Xu et al.
Background: Clinical and animal studies demonstrated that neuroinflammation from anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive disorders (PND). Recently, it was reported that micro...