Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion [0.03%]
人子宫内膜上皮干细胞的长期培养及其对宫腔粘连的治疗作用
Wen He,Xuejing Zhu,Aijie Xin et al.
Wen He et al.
Background: The human endometrium is a highly regenerative tissue that is believed to have two main types of stem cells: endometrial mesenchymal/stromal stem cells (eMSCs) and endometrial epithelial stem cells (eESCs). So...
Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium [0.03%]
基于人类尿源细胞体外重编程的条件培养基诱导生成可扩增中肾系中间体细胞及线粒体丰富肾脏器官簇
Yapei Yuan,Huan Chen,Sihua Ou et al.
Yapei Yuan et al.
Background: The kidneys require vast amounts of mitochondria to provide ample energy to reabsorb nutrients and regulate electrolyte, fluid, and blood pressure homeostasis. The lack of the human model hinders the investiga...
Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease [0.03%]
血浆代谢组学为冠心病代谢物与预后及左室重构的关系提供新见解
Qian Zhu,Min Qin,Zixian Wang et al.
Qian Zhu et al.
Background: Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventr...
RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression [0.03%]
RNA结合蛋白HuR通过抑制长链非编码RNA H19表达抵抗非酒精性脂肪肝病
Yanyan Wang,Yun-Ling Tai,Grayson Way et al.
Yanyan Wang et al.
Background: NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulat...
CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation [0.03%]
Cxcl12/cxcr7/βarrestin1偏向信号通过Yap1核转位抑制miRNA促进结直肠癌上皮间质转化
Mahan Si,Yujia Song,Xiaohui Wang et al.
Mahan Si et al.
Background: Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages o...
SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis [0.03%]
SK3神经元在能量和葡萄糖稳态中发挥性别二态性作用
Meng Yu,Jonathan C Bean,Hailan Liu et al.
Meng Yu et al.
Background: Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood. ...
Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing [0.03%]
单细胞RNA测序表征早期妊娠丢失的胎盘和蜕膜细胞发育
Yuhua Zheng,Jing Pan,Chenglai Xia et al.
Yuhua Zheng et al.
Background: Early pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects, EPL may result from impairment of the placental-decidual interface at ea...
Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity [0.03%]
鞘脂代谢抑制可保护成骨肉瘤免遭CD151介导的致瘤性影响
Hongsheng Wang,Xinmeng Jin,Yangfeng Zhang et al.
Hongsheng Wang et al.
Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarc...
Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington's disease-related phenotype [0.03%]
发现自噬诱导剂J3降低突变亨廷顿蛋白并改善亨廷顿病相关表型
Jiahui Long,Xia Luo,Dongmei Fang et al.
Jiahui Long et al.
Huntington's disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein encoded from extra tracts of CAG repeats in exon 1 of the HTT gene. mHTT proteins are neurotoxic to render the death of ...
Krüppel-like factor 7 deficiency causes autistic-like behavior in mice via regulating Clock gene [0.03%]
Krüppel样因子7通过调节Clock基因导致小鼠自闭症样的行为缺陷
Hui Tian,Yanwen Jiao,Mingyue Guo et al.
Hui Tian et al.
Background: Krüppel-like factor 7 (klf7), a transcription factor in the nervous system to regulate cell proliferation and differentiation, has been recently identified as a causal gene for autism spectrum disorder (ASD),...