Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis [0.03%]
缺氧通过改变雄性激素受体(AR)-长链非编码RNA-lncTCFL5-2-YBX1-SOX2信号轴增加RCC干细胞表型
Changcheng Guo,Yin Sun,Wei Zhai et al.
Changcheng Guo et al.
Background: Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its linkage to RCC progression under hypoxia, remains unclear. ...
Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis [0.03%]
中枢神经系统疾病的常见免疫病理生理学机制：蛋白稳态系统假设
Kyung-Yil Lee
Kyung-Yil Lee
There are hundreds of central nervous system (CNS) diseases, but there are few diseases for which the etiology or pathogenesis is understood as well as those of other organ-specific diseases. Cells in the CNS are selectively protected from ...
mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A [0.03%]
mTORC1-c-Myc信号通路通过抑制SIRT4介导的MAT2A的ADP核糖基化来重编程甲硫氨酸代谢从而促进HCC进展
Liang Zhao,Huizhao Su,Xiaomeng Liu et al.
Liang Zhao et al.
Background: Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic depende...
An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation [0.03%]
Semaphorein 3A的增加使轴突方向偏向并导致人类神经前体细胞分化体外模型中树突异常 Arborizations诱导
Gabriella Ferretti,Alessia Romano,Rossana Sirabella et al.
Gabriella Ferretti et al.
Background: Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members...
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate [0.03%]
TET蛋白介导的NANOG和SOX17之间的平衡调控人原始生殖细胞命运的决定
Zili Li,Fang Fang,Yuting Long et al.
Zili Li et al.
Background: Human primordial germ cells (hPGCs) initiate from the early post-implantation embryo at week 2-3 and undergo epigenetic reprogramming during development. However, the regulatory mechanism of DNA methylation du...
Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway [0.03%]
盐草素通过靶向NRF2/SIRT3通路减少阿尔茨海默病模型的神经病理损伤
Yuyuan Yao,Zhichu Ren,Ruihan Yang et al.
Yuyuan Yao et al.
Background: Neurite dystrophy is a pathologic hallmark of Alzheimer's disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored. ...
Vacuolin-1 enhances RA-induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP-76 axis subject to endosomal regulation that drives late differentiation steps [0.03%]
Vacuolin-1促进RA诱导的人髓样白血病细胞的分化：证据表明涉及溶酶体调节的CD11b/FAK/LYN/SLP-76轴推动晚期分化步骤
Kaiyuan Zhu,Noor Kazim,Jianbo Yue et al.
Kaiyuan Zhu et al.
Background: Retinoic acid(RA), an embryonic morphogen, regulates cell differentiation. Endocytosis regulates receptor signaling that governs such RA-directed cellular processes. Vacuolin-1 is a small molecule that disrupt...
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake [0.03%]
激活孤束核胰高血糖素样肽-1神经元抑制摄食行为
Ishnoor Singh,Le Wang,Baijuan Xia et al.
Ishnoor Singh et al.
Background: Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon 'Gcg' gene, produced in a distin...
Wasteosomes (corpora amylacea) of human brain can be phagocytosed and digested by macrophages [0.03%]
脑组织中的人类废用小体（淀粉样小体）可被巨噬细胞吞噬并消化
Marta Riba,Joan Campo-Sabariz,Iraida Tena et al.
Marta Riba et al.
Background: Corpora amylacea of human brain, recently renamed as wasteosomes, are granular structures that appear during aging and also accumulate in specific areas of the brain in neurodegenerative conditions. Acting as ...
Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation [0.03%]
肿瘤相关巨噬细胞通过诱导ZEB1介导的DNMT1转录激活增强乳腺癌恶性程度
Zhongwei Li,Pengfei Wang,Wenjie Cui et al.
Zhongwei Li et al.
Background: DNMT1 has been shown to be highly expressed in a variety of cancers, including breast cancer. However, the mechanism is not very clear. Therefore, we aim to reveal the mechanism of DNMT1 highly express in brea...