The cytoskeleton regulates cytoophidium dynamics in Drosophila ovaries [0.03%]
细胞骨架调节果蝇卵巢中的细胞蛇状结构动态变化
Xiao-Jing Liu,Yi-Lan Li,Shu-Yu Pang et al.
Xiao-Jing Liu et al.
Cytoophidia are filamentous structures composed of CTP synthase (CTPS) and were first identified in the ovarian cells of Drosophila. As a highly conserved, membraneless organelle present across all three domains of life, cytoophidia exhibit...
M2 polarization of macrophage induced by IL-33 promotes mouse sciatic nerve regeneration [0.03%]
白细胞介素-33诱导的巨噬细胞M2极化促进坐骨神经再生
Danyang Xu,Yanyi Li,Qi Zhang et al.
Danyang Xu et al.
Lactylation-related gene signature as a prognostic biomarker for neuroblastoma: insights into tumor progression and immune modulation [0.03%]
乳酰化相关基因特征作为神经母细胞瘤预后生物标志物的潜在作用：肿瘤进展和免疫调节的新见解
Jiangquan Zhu,Muyang Luo,Li Yuan et al.
Jiangquan Zhu et al.
Background: Lactylation, a recently identified post-translational modification mediated by lactate, plays a critical role in regulating metabolic and immune processes in tumors. However, its function in neuroblastoma, par...
Targeting epigenetic regulators to boost T cell immunotherapy against cancer [0.03%]
表观遗传调控在T细胞免疫治疗中的作用及机制研究
Tiaojiang Xiao,Ying E Zhang
Tiaojiang Xiao
Epigenetic regulation is crucial in directing T-cell differentiation, function, and fate, thereby influencing the success of T-cell-based immunotherapies. This review begins with an overview of the evolution of T-cell immunotherapies in can...
Inflammation-induced impairment of synaptic plasticity accelerates atherosclerosis co-depression disease: insights from bioinformatics analysis and transcriptomics [0.03%]
炎症诱发的突触可塑性损伤加速动脉粥样硬化共抑郁疾病的发生：来自生物信息学分析和转录组学的启示
Yulong Zhao,Qiang Luo,Peng Ren et al.
Yulong Zhao et al.
Background: Atherosclerosis (AS) serves as the pathological foundation for numerous cardiovascular and cerebrovascular diseases and is highly comorbid with depression. The mechanisms underlying this co-morbidity are excep...
DNA methylation-mediated silencing of MEOX1 promotes glycolysis and immune evasion in colorectal cancer cells through inhibition of GLP2R transcription [0.03%]
DNA甲基化介导的MEOX1基因沉默通过抑制GLP2R转录促进结直肠癌细胞糖酵解及免疫逃逸
Dingkong Liang,Fen Xue,Jinkun Xie et al.
Dingkong Liang et al.
Background: GLP2R has been identified as a downregulated gene in colorectal cancer (CRC) and is correlated with immunocyte infiltration. Herein, we aimed to define the molecular characteristics of GLP2R in CRC, focusing o...
In vitro mimicking of humanized cardiogenesis under porcine condition [0.03%]
体外模拟猪条件下的类人诱导多能干细胞心脏分化过程
Jiajun Li,Changjiang Xu,Bingbo Shi et al.
Jiajun Li et al.
Background: One promising strategy to generate humanized organs is through embryo complementation by injecting human pluripotent stem cells (PSCs) into gene-edited porcine embryos. This strategy is predicated on how human...
Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila [0.03%]
家蚕钙调神经磷酸酶通过prospero磷酸化维持神经干细胞的自我更新
Shuliu Zhang,Sifan Gong,Yiming Yang et al.
Shuliu Zhang et al.
Most neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis. However, the regulation of the NSC maintenance d...
Retraction Note: Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma [0.03%]
撤回 notice:胶质母细胞瘤干细胞（GSC）衍生的含 pd-l1 的外泌体激活 ampk/ulk1 通路介导的自噬以增加胶质母细胞瘤的替莫唑胺耐药性
Yong Zheng,Liang Liu,Yan Wang et al.
Yong Zheng et al.
The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair [0.03%]
SOX12和RNF168的互调调节通过调节DNA修复调控食管鳞癌细胞顺铂耐药性
Ning Wang,Lun Yang,Yunhe Huang et al.
Ning Wang et al.
Background: Resistance to chemotherapy drugs is one of the significant factors for limited treatment options and poor prognosis in esophageal cancer. A study has found that SOX12 plays a role in cisplatin resistance in he...