Gordonibacter-associated regulatory T cell dysfunction and S100A11-mediated neural impairment in Hirschsprung's disease: a microbiota-immune-neural axis [0.03%]
肠道菌群失调引起的戈登菌相关调节性T细胞功能障碍及S100A11介导的神经损伤在先天性巨结肠病中的作用：一种微生物-免疫-神经轴的作用机制
Ting Yao,Meili Fan,Zenghui Hao et al.
Ting Yao et al.
Background: Hirschsprung's disease (HSCR) is a congenital disorder characterized by intestinal aganglionosis. Despite evidence linking gut microbiota and immune cells to various gastrointestinal diseases, their role in HS...
Integrative genomic profiling of iron homeostasis predicts clinical outcomes and identifies HAMP/hepcidin as a therapeutic target in colorectal cancer [0.03%]
整合基因组分析鉴定出铁稳态的预后标志物及治疗靶点HAMP（hepcidin）用于结直肠癌
Yanfei Shao,Chaozhao Chen,Xian Zhang et al.
Yanfei Shao et al.
Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function [0.03%]
睾丸特异性长链非编码RNA Teshl调节顶体发生以维持精子结构和功能
Seung Pyo Hong,Seong Hyeon Hong,Gwidong Han et al.
Seung Pyo Hong et al.
Single-cell ATAC-seq analysis of human embryoid bodies reveals crucial transcription factor networks involved in early germ layer specification [0.03%]
单细胞ATAC测序分析人胚胎体揭示了早期胚层决定中关键的转录因子网络
Linying Li,Xiaoyu He,Feng Zhang et al.
Linying Li et al.
A rapid and highly sensitive CRISPR-Cas12a ortholog-assisted assay for genotyping of myostatin knockout pigs [0.03%]
一种快速且灵敏的用于肌苷基因敲出猪基因型鉴定的CRISPR-Cas12a同源物辅助测定法
Yuan Wang,Hui Yang,Wenhua Zhang et al.
Yuan Wang et al.
S100A8/A9-amplified inflammation (TNF-α/IL-1β) in the bone marrow of tumor-bearing host disrupts early B cell development [0.03%]
肿瘤携带者骨髓中放大炎症(TNF-α / IL-1β )的S100A8 / A9干扰早期B细胞发育
Pan Yang,Hao Wen,Xiaoling Chen et al.
Pan Yang et al.
Spontaneous whole genome duplication renders mouse embryonic fibroblasts resistant to reprogramming [0.03%]
自发性的基因组倍增使成纤维细胞抗拒重编程序化
Wei Li,Lingyu Zhong,Pengli Li et al.
Wei Li et al.
Microglial HDAC3 inhibits the migration of CD8-positive T cell in the development of EAE by restraining the expression of CCL5 [0.03%]
小胶质细胞HDAC3通过抑制CCL5表达限制CD8阳性T细胞在自身免疫性脑脊髓炎发病过程中的迁移
Na Che,Yang Zhang,Bo Wang et al.
Na Che et al.
The molecular mechanism underlying the differential subcellular distribution of dystrophin Dp71 isoforms [0.03%]
Duchenne营养不良蛋白Dp71异种体不同亚细胞分布的分子机制
Alma Alamillo-Iniesta,Griselda Velez-Aguilera,Feliciano Monterrubio-Ledezma et al.
Alma Alamillo-Iniesta et al.
Background: Dystrophin Dp71 is a versatile protein that plays a critical role in regulating diverse processes, including cell adhesion, nuclear architecture, neuronal differentiation, and synapse organization. Moreover, D...
Regulation of oncogenic C-terminal truncated p53β protein isoform expression by SRSF3-UPF1 splicing and surveillance axis [0.03%]
SRSF3-UPF1剪接和监视轴调控致癌型p53β蛋白异构体表达
Jiwon Jeong,Dawon Hong,Tae Young Park et al.
Jiwon Jeong et al.
Dysregulated expression of tumor suppressor genes can impair their functions, even promoting oncogenesis. Expression of p53β mRNA can be regulated by alternative splicing and RNA surveillance, otherwise translated to a C-terminal truncated...