SIAH2-EPHB6 axis enhances filopodia formation in hepatocellular carcinoma cells by regulating RHOF [0.03%]
SIAH2-EPHB6轴通过调节RHOF增强肝癌细胞的丝状伪足形成
Qinghe Hu,Kai Wu,Zhiyi Liu et al.
Qinghe Hu et al.
Seven in absentia homologue 2 (SIAH2) has been shown to contribute to the progression of various human tumors, including hepatocellular carcinoma (HCC). However, the precise mechanisms by which SIAH2 promotes HCC cell migration remain to be...
Integrator subunit IntS11 orchestrates the temporal dynamics of neural lineage progression in Drosophila [0.03%]
整合子亚基IntS11调控果蝇神经谱系发育的动态过程
Qiao Xiao,Liqiang Ai,Boquan Jia et al.
Qiao Xiao et al.
Background: IntS11, the core catalytic subunit of the Integrator (INT), functions in various stages of transcription. However, its specific function in orchestrating neural lineage progression remains poorly understood. ...
SIRT5-RNF126 coordinated regulation of METTL17 stability controls mitochondrial function and glioma progression [0.03%]
SIRT5-RNF126调控METTL17稳定性控制线粒体功能和胶质瘤进展
Chunyan He,Zixiao Zhang,Xiaoke Wu et al.
Chunyan He et al.
Gliomas are highly invasive brain tumors in which metabolic reprogramming plays a pivotal role in tumor initiation and progression. METTL17, a mitochondria-associated methyltransferase, has been reported to enhance oxidative phosphorylation...
A mouse model of HPV-associated cervicovaginal carcinosarcoma with comparative analysis to human clinical cases [0.03%]
人乳头瘤病毒相关宫颈阴道癌肉瘤的小鼠模型及与人类临床病例的比较分析
Jason Murray,Shiwen Peng,Chien-Fu Hung et al.
Jason Murray et al.
Background: Carcinosarcomas of the gynecologic tract, previously referred to as malignant mixed müllerian/mesodermal tumor, are devastating malignancies that remain poorly studied due to their rarity and the lack of rele...
Lactate metabolic reprogramming and lactylation modification: molecular mechanisms reshaping the tumor immunosuppressive microenvironment [0.03%]
乳酸代谢重构与乳酰化修饰：重塑肿瘤免疫抑制微环境的分子机制
Yuzhang Yuan,Yaping Gao,Jinhui Xue et al.
Yuzhang Yuan et al.
CircRSPRY1 regulates calcium oxalate crystal-induced necrotic apoptosis in renal tubules via miR-21-5p/PTEN [0.03%]
Circular RNA RSPRY1通过miR-21-5p/PTEN轴调节肾小管钙氧化物晶体诱导的坏死性凋亡
Xudong Shen,Xike Mao,Hu Liang et al.
Xudong Shen et al.
Dapagliflozin-intermittent fasting combination maximizes weight and metabolic regulation through AMPK/sirtuins/clock genes and gut microbiota signaling in high-fat diet-induced obesity: a novel anti-obesity approach [0.03%]
达格列净与间歇性禁食联合使用通过AMPK/sirtuins/clock基因和肠道菌群信号最大化高脂饮食诱导的肥胖小鼠体重和代谢调节：一种新的抗肥胖方法
Mahmoud A Senousy,Rana Mohamed Abo-Elmaaty,Nesreen Nabil Omar et al.
Mahmoud A Senousy et al.
Innovative and affordable treatment options are required to combat obesity and its detrimental impact on health economics. Dapagliflozin (Dapa), an antidiabetic medication, promotes weight loss; however, the extent of weight reduction may b...
Integrating single-cell and spatial transcriptomics to reveal the spatiotemporal dynamics of retinal cells during ischemia-reperfusion injury progression in rats [0.03%]
结合单细胞和空间转录组学揭示缺血再灌注损伤过程中大鼠视网膜细胞的时空动态变化
Yijia Huang,Junhong Guo,Fei Yao et al.
Yijia Huang et al.
Overexpression of ONECUT1 suppresses hepatoblastoma progression via modulating tumor cell growth and tumor microenvironment [0.03%]
ONECUT1过表达通过调节肿瘤细胞增殖和肿瘤微环境抑制肝母细胞瘤进展
Yu Qiao,Meng Xu,Yanhui Wu et al.
Yu Qiao et al.
Background: Hepatoblastoma is the most common malignant liver tumor in children. Our previous work showed that enforced expression of the transcription factor One Cut Homeobox 1 (ONECUT1) suppresses the initiation of hepa...
PFV Tas protein recruits hnRNPF to promote the splicing of tas/bet pre-mRNA [0.03%]
PFV Tas蛋白募集hnRNPF促进tas/bet前体mRNA的剪接
Shishun Wu,Chenxi Liu,Manman Qiu et al.
Shishun Wu et al.
Background: Foamy viruses (FVs) are capable of cross-species transmission to humans and establish latent infections without causing diseases. The transition between latent and lytic FV replication is regulated by the vira...