The methyltransferase activity of Dot1L is essential for Xenopus tropicalis tadpole development and survival [0.03%]
Dot1L甲基转移酶活性对热带非洲爪蟾蝌蚪发育和存活是必不可少的
Emeric M Louis,Nga Luu,Laurent M Sachs et al.
Emeric M Louis et al.
Epigenetic modifications of histones play key roles in transcriptional regulation by diverse transcription factors. One such modification is the methylation of histone H3 at lysine 79 (H3K79). The methyltransferase DOT1L is the only known, ...
USP30-AS1 functions as a post-transcriptional amplifier of interferon signalling to drive autoimmune pathogenesis [0.03%]
USP30-AS1通过调节干扰素信号转导的转录后放大功能驱动自身免疫性疾病的发生发展
Jie Pan,Min-Yi Feng,Tian Xia et al.
Jie Pan et al.
The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia-hypoxia leads to decreased thymic function via the HPA axis [0.03%]
新生儿脑缺血-缺氧诱发下丘脑神经炎症通过HPA轴降低胸腺功能的机制研究
Gai-Gai Liu,Li-Yan Shuang,Qian Zhang et al.
Gai-Gai Liu et al.
Hypoxic-ischemic encephalopathy (HIE) represents the leading cause of acute neonatal mortality and chronic neurological disorders. The impact of HIE on neonatal immune system development and the underlying mechanisms remain unclear. In this...
NOTCH2NLC GGC repeat expansions cause retinal neurodegeneration in neuronal intranuclear inclusion disease mouse model [0.03%]
NOTCH2NLC GGC重复序列扩增导致神经核内包涵体病小鼠模型视网膜神经退行性变
Haibo Li,Ying Jiang,Lusi Zhang et al.
Haibo Li et al.
Neuronal intranuclear inclusion disease (NIID) patients frequently exhibit ocular abnormalities, yet the pathogenic mechanisms remain unclear. Using a transgenic mouse model ubiquitously expressing NOTCH2NLC with 98GGC repeats, we revealed ...
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritis [0.03%]
芳烃受体介导的HSP70转录调控加剧狼疮性肾炎内质网应激反应
Min Wen,Jian Li,Yongzhen Li et al.
Min Wen et al.
Lactylation-related genes contribute to neurological injury and prognosis of acute ischemic stroke based on transcriptome and single-cell sequencing analysis [0.03%]
基于转录组和单细胞测序分析，乳酰化相关基因对急性缺血性卒中神经功能损伤及预后的影响
Jie Li,Lulu Zhu,Xiaolan Huang et al.
Jie Li et al.
Background: The rapid accumulation of lactate following cerebral ischemia has been well documented, however, the pathophysiological mechanisms underlying hyperlactate-induced lactylation in modulating neurological injury ...
Retraction Note: Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis [0.03%]
撤回 notice: 自噬介导的 notch1 细胞内结构域降解控制上皮到间质转化和癌症转移
Sahib Zada,Jin Seok Hwang,Trang Huyen Lai et al.
Sahib Zada et al.
Regulation of transcription by R loop-nucleated transcription condensate assembly [0.03%]
通过R环介导的转录凝聚组装调节转录
Raissa Regina Ng,Zhongyang Lin,Heng Wee Tan et al.
Raissa Regina Ng et al.
Prevalence of promoter paused R loops formed from frequent RNA PolII pausing in eukaryotic cells not only pose a significant threat to genomic stability, but also a potent regulator of transcription. In this review, we discuss how R loops a...
LncRNA HOXC-AS3 prevents chondrocyte senescence and osteoarthritis progression through miR-615-3p sponging and RRBP1 interaction [0.03%]
长链非编码RNA HOXC-AS3通过海绵吸附miR-615-3p和与RRBP1相互作用来防止软骨细胞衰老和骨关节炎进展
Chan Wang,Jun Zhou,Lulu Chen et al.
Chan Wang et al.
Background: Osteoarthritis (OA) is a widespread chronic joint disorder characterized by progressive cartilage degeneration, leading to substantial impairment in quality of life for millions of individuals globally. Cellul...
The impact and mechanisms of preeclampsia on offspring neurodevelopment [0.03%]
子代神经发育受妊娠期高血压影响及其机制研究
Ying Zhang,Li Bao,Ke-Zhi Li et al.
Ying Zhang et al.