Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis [0.03%]
钙蛋白酶剪切TRPV1的羧基末端并调节其快速适应性
Jin-Yan Jiang,Xiao-Chen Wang,Jing Yang et al.
Jin-Yan Jiang et al.
Background: Transient receptor potential vanilloid-1 (TRPV1) plays a critical role in noxious heat sensation in physiological conditions and pain hypersensitivity in pathological pain. Capsaicin, a classic TRPV1 agonist, ...
ESRG maintains human pluripotent stem cell self-renewal by binding NPM1 to regulate BMP4 protein and TGF-β signaling pathway [0.03%]
ESRG通过结合NPM1调节BMP4蛋白和TGF-β信号通路维持人类多能干细胞自我更新
Ziling Liao,Cong Zhao,Lei Wang et al.
Ziling Liao et al.
Human pluripotent stem cells (hPSCs) present considerable potential for regenerative medicine; however, the standardization and large-scale production of these cells are hindered by an incomplete understanding of the molecular mechanisms go...
BDNF-TrκB-PLCγ signaling drives BPA-induced mechanical allodynia through activating mechanosensitive Piezo2 channels [0.03%]
BDNF-TrκB-PLCγ信号通过激活机械敏感的Piezo2通道诱导双酚A引起的机械性痛觉过敏
Yuan-Ying Liu,Huan Guo,Hang Zhang et al.
Yuan-Ying Liu et al.
Background: Brachial plexus avulsion (BPA) induced neuropathic pain (NP) affects up to 90% patients with BPA, which is often characterized by mechanical allodynia. The gradual chronicity of the pain and the lack of effect...
Investigation of embryogenesis in a dish: the development and application of gastruloid models from pluripotent stem cells [0.03%]
用培养皿中的胚胎发育研究：多能干细胞来源的原肠胚样模型的发展与应用
Kexin Lin,Hanyumo Chen,Yuxin Chen et al.
Kexin Lin et al.
Gastrulation constitutes a critical phase of mammalian embryogenesis, during which the embryo undergoes morphological changes, germ layer determination, and body axes establishment, laying the foundation for subsequent embryonic development...
Key role of transcription factors network in proliferative vitreoretinal diseases development [0.03%]
转录因子网络在增殖性视网膜玻璃体疾病发生发展中的关键作用
Clément Duveau,Yosra Raiss El Harrak,Azine Datlibagi et al.
Clément Duveau et al.
Proliferative vitreoretinal diseases (PVDs) encompass severe ocular disorders such as proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy (PDR), and epiretinal membranes (ERM), characterized by the formation of fibrova...
Targeting the 5-HT1A receptor in the ventral hippocampus alleviates anxiety-like behavior in mice with angiotensin II-induced hypertension [0.03%]
靶向血管紧张素II诱导的高血压小鼠脑室海马体5-HT1A受体缓解焦虑样行为
Wenjun Chen,Zhoucai Luo,Mingfeng Huang et al.
Wenjun Chen et al.
Hypertension, a chronic condition, has affected > 1 billion people worldwide and is linked to a heightened risk of anxiety disorders. Despite this association, the exact mechanisms underlying the connections between hypertension and anxiety...
Cadmium impairs heart ventricular formation and disrupts polysialylated-NCAM/FGF receptor signaling in Xenopus tadpoles [0.03%]
镉通过破坏Xenopus蝌蚪中多唾液酸化-NCAM/FGF受体信号干扰心室形成
Pélagie Douchez,Ingrid Fliniaux,Yoshiko Takeda-Uchimura et al.
Pélagie Douchez et al.
Background: Exposure to cadmium, a trace metallic element, is a major health concern. Cadmium is associated with a higher risk and predisposition to cardiovascular disease. Identifying molecular targets involved in such a...
Inhibition of PTEN nuclear translocation by peptide Tat-K13 attenuates p-JUN-SESN2-AMPK-dependent autophagy and enhances neurological recovery after neonatal hypoxic-ischemic brain damage [0.03%]
PTEN核转位抑制肽Tat-K13通过削弱p-JUN-SESN2-AMPK依赖的自噬促进缺氧缺血性脑损伤后的神经功能恢复
Chunfang Dai,Xiaobin Wu,Xiaohuan Li et al.
Chunfang Dai et al.
Neuronal death triggered by hypoxia-ischemia (HI) is a major cause of neonatal mortality and long-term neurological deficits. Excessive autophagy plays a pathogenic role in neonatal hypoxic-ischemic encephalopathy (HIE), and inhibition of p...
Correction: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex [0.03%]
校正：RBX1通过破坏SMAR1/HDAC6复合物来调节PKM的可变剪接以促进甲状腺未分化癌转移和糖酵解上调
Debin Xu,Jichun Yu,Yuting Yang et al.
Debin Xu et al.
Published Erratum
Cell & bioscience. 2026 Apr 28;16(1):44. DOI:10.1186/s13578-026-01560-9 2026
Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS [0.03%]
Poly-GR促进C9orf72-ALS铁死亡相关易感性
Chun-Yu Lin,Wen-Chi Hsieh,Shao-Ming Wang
Chun-Yu Lin
Ferroptosis, an iron-dependent form of oxidative cell death driven by uncontrolled lipid peroxidation, has been increasingly implicated in neurodegeneration. However, its involvement and the underlying regulatory mechanism in C9orf72-linked...