Dapagliflozin-intermittent fasting combination maximizes weight and metabolic regulation through AMPK/sirtuins/clock genes and gut microbiota signaling in high-fat diet-induced obesity: a novel anti-obesity approach [0.03%]
达格列净与间歇性禁食联合使用通过AMPK/sirtuins/clock基因和肠道菌群信号最大化高脂饮食诱导的肥胖小鼠体重和代谢调节：一种新的抗肥胖方法
Mahmoud A Senousy,Rana Mohamed Abo-Elmaaty,Nesreen Nabil Omar et al.
Mahmoud A Senousy et al.
Innovative and affordable treatment options are required to combat obesity and its detrimental impact on health economics. Dapagliflozin (Dapa), an antidiabetic medication, promotes weight loss; however, the extent of weight reduction may b...
Integrating single-cell and spatial transcriptomics to reveal the spatiotemporal dynamics of retinal cells during ischemia-reperfusion injury progression in rats [0.03%]
结合单细胞和空间转录组学揭示缺血再灌注损伤过程中大鼠视网膜细胞的时空动态变化
Yijia Huang,Junhong Guo,Fei Yao et al.
Yijia Huang et al.
Overexpression of ONECUT1 suppresses hepatoblastoma progression via modulating tumor cell growth and tumor microenvironment [0.03%]
ONECUT1过表达通过调节肿瘤细胞增殖和肿瘤微环境抑制肝母细胞瘤进展
Yu Qiao,Meng Xu,Yanhui Wu et al.
Yu Qiao et al.
Background: Hepatoblastoma is the most common malignant liver tumor in children. Our previous work showed that enforced expression of the transcription factor One Cut Homeobox 1 (ONECUT1) suppresses the initiation of hepa...
PFV Tas protein recruits hnRNPF to promote the splicing of tas/bet pre-mRNA [0.03%]
PFV Tas蛋白募集hnRNPF促进tas/bet前体mRNA的剪接
Shishun Wu,Chenxi Liu,Manman Qiu et al.
Shishun Wu et al.
Background: Foamy viruses (FVs) are capable of cross-species transmission to humans and establish latent infections without causing diseases. The transition between latent and lytic FV replication is regulated by the vira...
Gordonibacter-associated regulatory T cell dysfunction and S100A11-mediated neural impairment in Hirschsprung's disease: a microbiota-immune-neural axis [0.03%]
肠道菌群失调引起的戈登菌相关调节性T细胞功能障碍及S100A11介导的神经损伤在先天性巨结肠病中的作用：一种微生物-免疫-神经轴的作用机制
Ting Yao,Meili Fan,Zenghui Hao et al.
Ting Yao et al.
Background: Hirschsprung's disease (HSCR) is a congenital disorder characterized by intestinal aganglionosis. Despite evidence linking gut microbiota and immune cells to various gastrointestinal diseases, their role in HS...
Integrative genomic profiling of iron homeostasis predicts clinical outcomes and identifies HAMP/hepcidin as a therapeutic target in colorectal cancer [0.03%]
整合基因组分析鉴定出铁稳态的预后标志物及治疗靶点HAMP（hepcidin）用于结直肠癌
Yanfei Shao,Chaozhao Chen,Xian Zhang et al.
Yanfei Shao et al.
Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function [0.03%]
睾丸特异性长链非编码RNA Teshl调节顶体发生以维持精子结构和功能
Seung Pyo Hong,Seong Hyeon Hong,Gwidong Han et al.
Seung Pyo Hong et al.
Single-cell ATAC-seq analysis of human embryoid bodies reveals crucial transcription factor networks involved in early germ layer specification [0.03%]
单细胞ATAC测序分析人胚胎体揭示了早期胚层决定中关键的转录因子网络
Linying Li,Xiaoyu He,Feng Zhang et al.
Linying Li et al.
A rapid and highly sensitive CRISPR-Cas12a ortholog-assisted assay for genotyping of myostatin knockout pigs [0.03%]
一种快速且灵敏的用于肌苷基因敲出猪基因型鉴定的CRISPR-Cas12a同源物辅助测定法
Yuan Wang,Hui Yang,Wenhua Zhang et al.
Yuan Wang et al.
S100A8/A9-amplified inflammation (TNF-α/IL-1β) in the bone marrow of tumor-bearing host disrupts early B cell development [0.03%]
肿瘤携带者骨髓中放大炎症(TNF-α / IL-1β )的S100A8 / A9干扰早期B细胞发育
Pan Yang,Hao Wen,Xiaoling Chen et al.
Pan Yang et al.