ELYS promotes hepatocellular carcinoma stemness by activating a FOXO6-NUP205 transcriptional module downstream of PI3K/AKT to drive Hedgehog signaling [0.03%]
ELYLS通过激活FOXO6-NUP205转录模块促进肝癌干细胞特性来驱动Hedgehog信号通路
Xin Chen,Qing Zhang,Fen Xie et al.
Xin Chen et al.
Background: Hepatocellular carcinoma (HCC) is a lethal malignancy driven by cancer stem cells, which drive progression and therapeutic resistance. Nuclear pore protein ELYS is implicated in tumorigenesis, but its role in ...
lncRNA-operated stem cell fate control: RPS3 mediates the in situ Gm16751-Zhx3 interactome to program spermatogonial stem cell differentiation [0.03%]
长非编码RNA操控干细胞分化命运：RPS3介导Gm16751-Zhx3原位蛋白互作簇调控精原干细胞分化编程
Weijun Gao,Bo Xu,Wenzhi Ma et al.
Weijun Gao et al.
Background: Long non-coding RNAs (lncRNAs) play pivotal regulatory roles in mammalian male gametogenesis. Advances in high-throughput technologies have demonstrated that lncRNAs orchestrate robust, flexible, and context-s...
Epineuronal space: an emerging hidden hierarchy bridges neuron and mind space [0.03%]
围绕神经原的空隙：一个新兴的隐性等级制度连接神经元和心灵空间
Yi-Xi Zhang,Qiang-Long You,Xiang-Dong Sun
Yi-Xi Zhang
The emergent nature of life hinders reductionist paradigms of mapping microscale fundamental components with macroscale phenotypes. Such dilemma of mapping problems can be resolved through seeking hidden hierarchies among them. In developme...
Brain-wide spatiotemporal mapping of glutamate/GABA dual-transmitter neurons during postnatal development in mice [0.03%]
小鼠出生后发育期间谷氨酸/γ-氨基丁酸双递质神经元的脑区时空图谱
Cong Zhou,Shihan Cheng,Haofu Zheng et al.
Cong Zhou et al.
Emerging evidence suggests that individual neurons can utilize multiple neurotransmitters, challenging traditional views of neuronal identity. However, as most studies to date have focused on the adult stage, a fundamental question remains:...
Decoding the role of H19 in cholestatic liver injury using snRNA-seq, spatial transcriptomics, and machine learning-based disease prediction [0.03%]
使用snRNA测序、空间转录组学和基于机器学习的疾病预测解码H19在胆汁淤积性肝损伤中的作用
Grayson W Way,Xixian Jiang,Hongkun Lu et al.
Grayson W Way et al.
Background: Despite recent advances, Primary Sclerosing Cholangitis (PSC)-a chronic obstructive biliary disease-still lacks effective therapies to prevent disease progression or the need for liver transplantation. Moreove...
Neddylation is indispensable for early meiotic progression in spermatocytes via destabilizing HORMAD1 by SCF ubiquitin E3 ligase during synapsis [0.03%]
通过SCF泛素E3连接酶在联会过程中降解HORMAD1， Neddylation对精子细胞早期减数分裂进程至关重要
Ningyuan Tang,Qinghua Guo,Wenzhen Zhao et al.
Ningyuan Tang et al.
Background: The organized chromatin configuration in meiosis prophase I is crucial for spermatogenesis and male fertility, involving a series of tightly coordinated events mediated by numerous proteins. Neddylation, a ubi...
Monoclonal antibody passive experimental autoimmune myasthenia gravis: current progress and future directions [0.03%]
单克隆抗体被动实验性自身免疫重症肌无力的现状和未来方向
Liting Zheng,Jianghao Wang,Siying Tang et al.
Liting Zheng et al.
Experimental Autoimmune Myasthenia Gravis (EAMG) remains a cornerstone platform for mechanistic studies of pathogenic antibodies in myasthenia gravis (MG). In particular, monoclonal antibody passive-transfer EAMG (mAb-PTMG) has been instrum...
Cannabidiol enhances tamoxifen efficacy via CREB-mediated suppression of ERα signaling in ER-positive breast cancer cells [0.03%]
大麻二酚通过CREB介导的ERα信号传导抑制作用增强阳性乳腺癌细胞三苯氧胺疗效
Bu Gyeom Kim,Okhyeon Kim,Do-Yeon Lee et al.
Bu Gyeom Kim et al.
Background: Estrogen receptor alpha (ERα) plays a crucial role in the proliferation and survival of ER-positive breast cancer cells, and tamoxifen (TAM) remains the mainstay of endocrine therapy. However, acquired resist...
The transmembrane segments of SARS-CoV-2 nsp3 govern viral intracellular trafficking [0.03%]
SARS-CoV-2 nsp3的跨膜区段调控病毒胞内转运
Manqi Cao,Lang Qin,Huaan Zhang et al.
Manqi Cao et al.
After entry, coronaviruses deliver their genomic RNA to the ER-Golgi intermediate compartment to build replication organelles, yet how the RNA first contacts membranes is unclear. Here, we demonstrate that the first transmembrane helix of n...
LBH deficiency influences the therapeutic effects of regulatory B cells through the regulation of IL-10 production via the Rap1 pathway [0.03%]
LBH通过Rap1信号转导调控IL-10的产生从而影响调节性B细胞的治疗作用
Weijia Bao,Ke Hu,Yuan Qu et al.
Weijia Bao et al.
Regulatory B cells (Bregs) are immune cells that affect the autoimmune response by producing interleukin (IL)-10, but the molecular mechanism affecting Breg differentiation and IL-10 production is not clear. Our study found that mice with l...