Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis [0.03%]
脱泛素酶USP10通过调节GSK3β-ULK1轴促进骨肉瘤自噬和进展
Zuxi Feng,Yanghuan Ou,Xueqiang Deng et al.
Zuxi Feng et al.
Background: Deubiquitinating enzymes (DUBs) are pivotal in maintaining cell homeostasis by regulating substrate protein ubiquitination in both healthy and cancer cells. Ubiquitin-specific protease 10 (USP10) belongs to th...
V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor [0.03%]
通过旁分泌产生胰高血糖素激活GLP-1受体促进葡萄糖刺激的胰岛素分泌
Ying Yun,Shimeng Guo,Xin Xie
Ying Yun
Background: Arginine vasopressin (AVP) has been reported to regulate insulin secretion and glucose homeostasis in the body. Previous study has shown that AVP and its receptor V1bR modulate insulin secretion via the hypoth...
Wei Wang,Chao Huang,Li Zhang et al.
Wei Wang et al.
Background: Gallbladder cancer (GBC) is characterized by high mortality rate. Our study sought therapeutic candidates for GBC. Results: ...
Organoid as a promising tool for primary liver cancer research: a comprehensive review [0.03%]
类器官在肝癌研究中的应用及展望——肝癌类器官模型的建立、应用及其挑战与未来方向综述
Xuekai Hu,Jiayun Wei,Pinyan Liu et al.
Xuekai Hu et al.
Primary liver cancer (PLC) is one of the most common malignant gastrointestinal tumors worldwide. Limited by the shortage of liver transplantation donors and the heterogeneity of tumors, patients with liver cancer lack effective treatment o...
Insights into the m6A demethylases FTO and ALKBH5 : structural, biological function, and inhibitor development [0.03%]
FTO和ALKBH5的结构、功能及抑制剂研究取得新进展
Zewei Gao,Xuan Zha,Min Li et al.
Zewei Gao et al.
N6-methyladenosine (m6A) is dynamically regulated by methyltransferases (termed "writers") and demethylases (referred to as "erasers"), facilitating a reversible modulation. Changes in m6A levels significantly influence cellular functions, ...
Reduction of eEF2 kinase alleviates the learning and memory impairment caused by acrylamide [0.03%]
eEF2激酶表达沉默缓解丙烯酰胺导致的学习记忆损伤作用研究
Xiao-Li Wang,Ru-Nan Zhang,Yu-Lin Pan et al.
Xiao-Li Wang et al.
Background: The impact of acrylamide (ACR) on learning and memory has garnered considerable attention. However, the targets and mechanisms are still unclear. ...
Signaling pathways activated and regulated by stem cell-derived exosome therapy [0.03%]
干细胞来源的外泌体疗法激活和调节的信号通路
Ding Li,Danni Li,Zhao Wang et al.
Ding Li et al.
Stem cell-derived exosomes exert comparable therapeutic effects to those of their parental stem cells without causing immunogenic, tumorigenic, and ethical disadvantages. Their therapeutic advantages are manifested in the management of a br...
Lack of basic rationale in epithelial-mesenchymal transition and its related concepts [0.03%]
上皮间质转化及其相关概念的基本逻辑缺陷分析
Ying Cao
Ying Cao
Epithelial-mesenchymal transition (EMT) is defined as a cellular process during which epithelial cells acquire mesenchymal phenotypes and behavior following the downregulation of epithelial features. EMT and its reversed process, the mesenc...
SOX2 interacts with hnRNPK to modulate alternative splicing in mouse embryonic stem cells [0.03%]
Sox2通过与hnRNPK相互作用调控小鼠胚胎干细胞的可变剪接
Yanlan Huang,Yuxuan Liu,Mingyi Pu et al.
Yanlan Huang et al.
Background: SOX2 is a determinant transcription factor that governs the balance between stemness and differentiation by influencing transcription and splicing programs. The role of SOX2 is intricately shaped by its intera...
The tripartite motif-containing 24 is a multifunctional player in human cancer [0.03%]
三聚体基序蛋白24在人类癌症中的多功能作用
Yuanbing Yao,Sheng Zhou,Yue Yan et al.
Yuanbing Yao et al.
Tripartite motif-containing 24 (TRIM24), also known as transcriptional intermediary factor 1α (TIF1α), is the founding member of TIF1 family. Recent evidence indicates that aberrant expression of TRIM24, functions as an oncogene, is assoc...