Xin Liu,Jing Wang,Yaoxian Xiang et al.
Xin Liu et al.
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins. Extensive research indicat...
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer's disease [0.03%]
阿尔茨海默病淀粉样蛋白osis转基因小鼠模型中的性别特异性下丘脑神经病理学和糖代谢
Guibo Qi,Han Tang,Pifang Gong et al.
Guibo Qi et al.
Background: Amyloid toxicity and glucose metabolic disorders are key pathological features during the progression of Alzheimer's disease (AD). While the hypothalamus plays a crucial role in regulating systemic energy bala...
New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment [0.03%]
新的研究表明肿瘤微环境中的间质细胞相互作用分子2的功能及其对免疫调节的影响
Shishan Zhou,Shujie Liu,Anfeng Jiang et al.
Shishan Zhou et al.
Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-prolongation even curable in some cancer patients. Although so, most of the patients show no response. Tumor microenvironment (TME) where immune cells settle down h...
Advances in predictive biomarkers associated with immunotherapy in extensive-stage small cell lung cancer [0.03%]
广泛期小细胞肺癌相关免疫治疗的预测生物标志物研究进展
Tong Chen,Mingzhao Wang,Yanchao Chen et al.
Tong Chen et al.
Small cell lung cancer (SCLC) is a highly malignant and poor-prognosis cancer, with most cases diagnosed at the extensive stage (ES). Amidst a landscape marked by limited progress in treatment modalities for ES-SCLC over the past few decade...
Single‑cell RNA sequencing analysis of human embryos from the late Carnegie to fetal development [0.03%]
卡内基第10至23期的人类胚胎单细胞RNA测序分析
Chengniu Wang,Xiaorong Wang,Wenran Wang et al.
Chengniu Wang et al.
Background: The cell development atlas of transition stage from late Carnegie to fetal development (7-9 weeks) remain unclear. It can be seen that the early period of human embryos (7-9 weeks) is a critical research gap. ...
HBx promotes tumorigenicity through RRM2-mediated autophagy in hepatocellular carcinoma [0.03%]
HBx通过RRM2介导的自噬促进肝癌细胞恶性转化能力增强
Yaqun Li,Furan Wang,Zikai Geng et al.
Yaqun Li et al.
Background: Hepatitis B virus (HBV) infection can exacerbate liver disease progression through multiple mechanisms, eventually leading to hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key regulat...
Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19 [0.03%]
冠心苷橄榄苦苷诱导GRP78致压以双效抑制癌症和新冠肺炎病毒感染
Dat P Ha,Woo-Jin Shin,Ze Liu et al.
Dat P Ha et al.
Background: Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone...
Xiao Zhang,Tao Wang
Xiao Zhang
Understanding of the mechanisms for genome integrity maintenance can help in developing effective intervention strategies to combat aging. A whole-genome RNAi screen was conducted to identify novel factors involved in maintaining genome sta...
Role of extracellular vesicle-associated proteins in the progression, diagnosis, and treatment of hepatocellular carcinoma [0.03%]
外泌体相关蛋白在肝细胞癌进展、诊断和治疗中的作用
Yao-Ge Liu,Shi-Tao Jiang,Jun-Wei Zhang et al.
Yao-Ge Liu et al.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, characterized by difficulties in early diagnosis, prone to distant metastasis, and high recurrence rates following surgery. Extracellular vesicles (EVs) are a c...
Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas [0.03%]
单细胞和空间测序鉴定出鳞状上皮瘤和生殖肿瘤细胞Adamantinomatous颅咽管瘤
Xianlong Wang,Jincheng Lin,Hongxing Liu et al.
Xianlong Wang et al.
Adamantinomatous craniopharyngioma (ACP) is a clinically aggressive tumor without effective treatment method. Previous studies proposed a paracrine tumorigenesis model, in which oncogenic β-catenin induces senescence in pituitary stem cell...