Revisiting Virchow's triad: exploring the cellular and molecular alterations in cerebral venous congestion [0.03%]
重温Virchow三角：探讨脑静脉淤血的细胞和分子改变
Chen Zhou,Yifan Zhou,Wei Ma et al.
Chen Zhou et al.
Background: Cerebral venous thrombosis (CVT) is a rare but serious condition that can lead to significant morbidity and mortality. Virchow's triad elucidates the role of blood hypercoagulability, blood flow dynamics, and ...
Yifei Chen,Yihui Wu,Xianyan Tian et al.
Yifei Chen et al.
The Golgi apparatus is the central hub of the cellular endocrine pathway and plays a crucial role in processing, transporting, and sorting proteins and lipids. Simultaneously, it is a highly dynamic organelle susceptible to degradation or f...
HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis [0.03%]
HPV16整合通过c-Myc/miR-142-5p/HOXA5/SLC7A11轴调节铁死亡抵抗在宫颈癌变期间的作用
Xiao-Jing Chen,Chu-Hong Guo,Yang Yang et al.
Xiao-Jing Chen et al.
Background: Ferroptosis, a newly identified form of regulated cell death triggered by small molecules or specific conditions, plays a significant role in virus-associated carcinogenesis. However, whether tumours arising a...
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice [0.03%]
糖类抗原抑制减少小鼠脊髓损伤后的纤维化并促进功能恢复
Fangli Shan,Jianan Ye,Xinzhong Xu et al.
Fangli Shan et al.
Background: In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platele...
CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma [0.03%]
CASTOR1磷酸化预测KRAS突变型肺腺癌男性的不良预后
Suet Kee Loo,Gabriel Sica,Xian Wang et al.
Suet Kee Loo et al.
Background: Lung cancer, a leading global cause of cancer-related mortality, necessitates enhanced prognostic markers for improved treatment outcomes. We have previously shown a tumor suppressive role of cytosolic arginin...
Transcription and post-translational mechanisms: dual regulation of adiponectin-mediated Occludin expression in diabetes [0.03%]
糖尿病中通过转录和翻译后机制的双效调节调控脂联素介导的闭锁蛋白表达
Yanru Duan,Demin Liu,Huahui Yu et al.
Yanru Duan et al.
Background: Occludin, a crucial component of tight junctions, has emerged as a promising biomarker for the diagnosis of acute ischemic disease, highlighting its significant potential in clinical applications. In the diabe...
Sbno1 mediates cell-cell communication between neural stem cells and microglia through small extracellular vesicles [0.03%]
Sbno1通过小型细胞外囊泡介导神经干细胞和小胶质细胞之间的细胞间通讯
Yifan Zhang,Zhihan Zhu,Zhinuo Li et al.
Yifan Zhang et al.
Background: Neural stem cells (NSCs) play a crucial role in the progress of ischemic stroke. Research on zebrafish embryonic demonstrates an association between Strawberry Notch 1 (Sbno1) and central nervous system develo...
Reading the m6A-encoded epitranscriptomic information in development and diseases [0.03%]
阅读m6A编码的表观转录组信息在发育和疾病中的作用
Yunbing Chen,Ziyu Zhou,Yanxi Chen et al.
Yunbing Chen et al.
N6-methyladenosine (m6A) represents the most prevalent internal and reversible modification on RNAs. Different cell types display their unique m6A profiles, which are determined by the functions of m6A writers and erasers. M6A modifications...
Dong Jiacheng,Cui Jiayue,Guo Ying et al.
Dong Jiacheng et al.
The emergence of programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) immunosuppressants provides new therapeutic directions for various advanced malignant cancers. At present, PD-1/PD-L1 immunosuppressants have made significant ...
Astaxanthin attenuates glucose-induced liver injury in largemouth bass: role of p38MAPK and PI3K/Akt signaling pathways [0.03%]
虾青素通过p38丝裂原活化蛋白激酶和磷脂酰肌醇3-激酶/蛋白激酶B信号通路减轻罗非鱼的高血糖损伤
Zhihong Liao,Xuanshu He,Anqi Chen et al.
Zhihong Liao et al.
Background: Astaxanthin (ASX) has been documented to exert beneficial influence on various processes in fish. Largemouth bass (Micropterus salmoides) serves as a common model for studying glucose-induced liver disease, ma...