Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12 [0.03%]
剪接因子SRSF1通过调控Bcl2l12可变剪接抑制心肌细胞凋亡
Yilin Xie,Zhenbo Yang,Wenxian Chen et al.
Yilin Xie et al.
Background: Aberrant alternative splicing (AS) events, triggered by the alterations in serine/arginine splicing factor 1 (SRSF1), a member of the SR protein family, have been implicated in various pathological processes. ...
CXCL11 reprograms M2-biased macrophage polarization to alleviate pulmonary fibrosis in mice [0.03%]
CXCL11使向M2倾斜的巨噬细胞极化再编程以缓解小鼠肺纤维化
Ji-Young Kim,Dong-Wook Cho,Jung-Yun Choi et al.
Ji-Young Kim et al.
Background: In understanding the pathophysiology of pulmonary fibrosis (PF), macrophage plasticity has been implicated with a crucial role in the fibrogenic process. Growing evidence indicates that accumulation of M2 macr...
Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2 [0.03%]
始祖逆转录病毒包膜蛋白ERVWE1通过激活AK2诱导神经元线粒体功能障碍并上调精神分裂症潜在生物标志物circ_0001810
Wenshi Li,Xing Xue,Xuhang Li et al.
Wenshi Li et al.
Background: Increasingly studies highlight the crucial role of the ancestral retrovirus envelope protein ERVWE1 in the pathogenic mechanisms of schizophrenia, a severe psychiatric disorder affecting approximately 1% of th...
A novel function for α-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction [0.03%]
α-突触核蛋白作为嗅球NCK2调控因子的新功能及其在嗅觉中的作用机制
Jing Ren,Chao Wu,Mengxia Zeng et al.
Jing Ren et al.
To investigate physiological function of α-synuclein is important for understanding its pathophysiological mechanism in synucleinopathies including Parkinson's disease. Employing knockout mice, we found that Snac/α-synuclein deletion indu...
Stearoyl-CoA desaturase in CD4+ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8+ T cells [0.03%]
CD4+T细胞中硬脂酰辅酶A去饱和酶通过激活CD8+T细胞中的CXCR3 / CXCL11轴抑制肿瘤生长
Sung-Hyun Hwang,Yeseul Yang,Jae-Ha Jung et al.
Sung-Hyun Hwang et al.
Background: Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4+ tumor-infiltrating lymphocytes (TILs) r...
Jiahao Zhang,Yao Zhu,Meng Zhang et al.
Jiahao Zhang et al.
Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, and maintaining the resting membrane potential. A growing number of studies have indicated t...
Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice [0.03%]
肝细胞线粒体钙单向转运蛋白下调通过减少小鼠MASH和纤维化来发挥保护作用
Shuyu Li,Fangyuan Chen,Min Liu et al.
Shuyu Li et al.
Background: Mitochondrial calcium uniporter (MCU) plays pleiotropic roles in cellular physiology and pathology that contributes to a variety of diseases, but the role and potential mechanism of MCU in the pathogenesis of ...
Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques [0.03%]
药物性肝损伤研究进展：体外模型、机制、组学和基因调控技术
Kaidi Guo,Twan van den Beucken
Kaidi Guo
Drug-induced liver injury (DILI) refers to drug-mediated damage to the structure and function of the liver, ranging from mild elevation of liver enzymes to severe hepatic insufficiency, and in some cases, progressing to liver failure. The m...
Qian Su,Huizhen Sun,Ling Mei et al.
Qian Su et al.
Ribosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also in various extra-ribosomal functions, some of which are implicated in the development of different types of tumors. A...
Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits [0.03%]
磷二酯酶抑制和Gucy2C激活增强酪氨酸羟化酶Ser40磷酸化并改善6-羟基多巴胺诱导的运动缺陷
Erik H Douma,Jesse Stoop,Matthijs V R Lingl et al.
Erik H Douma et al.
Background: Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the nigrostriatal pathway, leading to dopamine deficiency and motor impairments. Current treatments, such as L-DOPA, provid...