Impact of c-JUN deficiency on thalamus development in mice and human neural models [0.03%]
c-JUN缺乏对小鼠和人类神经模型丘脑发育的影响
Jiantao Shi,Qing Chen,Jianheng Lai et al.
Jiantao Shi et al.
Background: c-Jun is a key regulator of gene expression. Through the formation of homo- or heterodimers, c-JUN binds to DNA and regulates gene transcription. While c-Jun plays a crucial role in embryonic development, its ...
Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma [0.03%]
单细胞多组学分析揭示了胶质母细胞瘤的间充质亚型候选治疗药物和关键转录因子
Yufan Yang,Ziyuan Liu,Yerong Wei et al.
Yufan Yang et al.
The inherent heterogeneity of tumor cells impedes the development of targeted therapies for specific glioblastoma (GBM) subtypes. This study aims to investigate the mesenchymal subtype of GBM to uncover detailed characteristics, potential t...
Correction: ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration [0.03%]
关于纠正ALKBH5介导的Runx2 mRNA去甲基化促进细胞外基质降解和椎间盘退变的作用机制研究中的错误
Yu Lei,Enyu Zhan,Chao Chen et al.
Yu Lei et al.
Published Erratum
Cell & bioscience. 2024 Dec 21;14(1):152. DOI:10.1186/s13578-024-01330-5 2024
Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases [0.03%]
信号调节蛋白α介导巨噬细胞极化促进缺血性疾病的改善
Haiyi Liu,Yonghui Yuan,Takerra K Johnson-Stephenson et al.
Haiyi Liu et al.
Background: macrophage-targeting therapy of ischemic disease has made progress in clinic trial. However, the role and underlying mechanism of pro-inflammatory or anti-inflammatory polarized macrophages in modulating ische...
Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis [0.03%]
通过孟德尔随机化分析识别糖尿病多发性神经病变的潜在药物靶点
Xiaokun Chen,Guohua Jiang,Tianjing Zhao et al.
Xiaokun Chen et al.
Background: Diabetic polyneuropathy (DPN) is a common diabetes complication with limited treatment options. We aimed to identify circulating plasma proteins as potential therapeutic targets for DPN using Mendelian Randomi...
Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice [0.03%]
纹状体乙酰胆碱促进帕金森病模型小鼠多巴胺释放和纹状体神经元输出作用研究
Hongxia Li,Ziluo Chen,Yuyan Tan et al.
Hongxia Li et al.
Background: L-DOPA has been considered the first-line therapy for treating Parkinson's disease (PD) via restoring striatal dopamine (DA) to normalize the activity of local spiny projection neurons (SPNs) in the direct (dS...
Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery [0.03%]
儿童单纯性肥胖的多组学景观：对发病机制和生物标志物发现的新见解
Yi Ren,Peng Huang,Lu Zhang et al.
Yi Ren et al.
Background: The increasing incidence of childhood obesity annually has led to a surge in physical and mental health risks, making it a significant global public health concern. This study aimed to discover novel biomarker...
CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC [0.03%]
口腔癌干细胞样特性通过CAF分泌乳酸抑制MST1泛素化降解增强
Shuzhen Zhang,Jingjing Wang,Yang Chen et al.
Shuzhen Zhang et al.
Background: Cancer-associated fibroblasts (CAFs), a predominant stromal cell type in the tumor microenvironment, significantly affect the progression of oral squamous cell carcinoma (OSCC). ...
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma [0.03%]
溴结构域蛋白有望成为治疗B细胞非霍奇金淋巴瘤的药物作用靶点
Dan Zou,Sitong Feng,Bowen Hu et al.
Dan Zou et al.
Background: B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of lymphoma and is significantly heterogeneous among various subtypes. Despite of considerable advancements in treatment strategies for B-NHL, the pr...
Dietary contributions in the genetic variation of liver fibrosis: a genome-wide association study of fibrosis-4 index in the liver fibrosis development [0.03%]
基于肝纤维化发展中的基因组关联研究探求饮食因素在肝纤维化遗传变异中的作用：一项FIB-4指数的全基因组关联分析研究
Poppy Diah Palupi,Chun-Yu Wei,Wan-Hsuan Chou et al.
Poppy Diah Palupi et al.
Background: The fibrosis-4 (FIB-4) index is a non-invasive method to assess the severity of liver fibrosis. The development of liver fibrosis is influenced by genetic predisposition and dietary factors. However, the modul...