Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation [0.03%]
人多能干细胞来源的类胚胎心脏器官与胎儿阶段相似，并具有潜在的心肌细胞转分化的可能性
Fanwen Wang,Xinle Zou,Huilin Zheng et al.
Fanwen Wang et al.
Epicardium, the most outer mesothelium, exerts crucial functions in fetal heart development and adult heart regeneration. Here we use a three-step manipulation of WNT signalling entwined with BMP and RA signalling for generating a self-orga...
DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma [0.03%]
乙醛脱氢酶活性下降的肝癌细胞诱导免疫反应的研究进展及机制探讨：ACADS启动子高甲基化在其中的作用
Ze Qian,Yifan Jiang,Yacong Wang et al.
Ze Qian et al.
Background: Altered metabolism has become an important characteristic of cancer, and acyl-CoA dehydrogenase short-chain (ACADS), a regulator of lipid synthesis, is involved in carcinogenesis-associated metabolic pathways....
Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury [0.03%]
脊髓损伤后AEA-TRPV1/CB1R平衡稳态的适应不良变化导致伤害性感觉神经元痛觉相关过度活动
JiaQi Hu,WenYong Fan,Yue Xu et al.
JiaQi Hu et al.
Background: Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptors. Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic tr...
Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes [0.03%]
单核RNA测序揭示自发性早产亚型中胎盘滋养细胞的病理生理特征
Cherilyn Uhm,Jianlei Gu,Weina Ju et al.
Cherilyn Uhm et al.
Spontaneous preterm birth (sPTB) poses significant challenges, affecting neonatal health and neurodevelopmental outcomes worldwide. The specific effects of placental trophoblasts on the pathological development of sPTB subtypes-preterm prem...
PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation [0.03%]
PTL2突变影响人类卵母细胞的母体mRNA稳态和细胞周期调节中的蛋白质相互作用
Yin-Li Zhang,Zhanhong Hu,Huifang Jiang et al.
Yin-Li Zhang et al.
Background: Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely u...
Unraveling the protein kinase C/NDRG1 signaling network in breast cancer [0.03%]
乳腺癌中蛋白激酶C/NDRG1信号网络的解析研究
C Saponaro,M Damato,E Stanca et al.
C Saponaro et al.
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central role in a wide range of biological processes including stress response, differentiation, and metabolism. The overexpressi...
Nathan Xu,Kyle Yang,Mengjie Wang
Nathan Xu
Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. Meeting this demand requires the activation of a brain-breast-bone circuit during lactation that coordinates changes in ...
Improved efficacy of therapeutic HPV DNA vaccine using intramuscular injection with electroporation compared to conventional needle and needle-free jet injector methods [0.03%]
与传统的针剂和无针喷射器方法相比，使用电穿孔肌肉注射的治疗性HPV DNA疫苗疗效更佳
Shiwen Peng,Darrell Fan,Hsin-Fang Tu et al.
Shiwen Peng et al.
Background: We have previously developed a candidate therapeutic HPV DNA vaccine (pBI-11) encoding mycobacteria heat shock protein 70 linked to HPV16/18 E6/E7 proteins for the control of advanced HPV-associated oropharyng...
SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer [0.03%]
SIRT6缺乏通过抑制UHRF1去乙酰化和泛素化增强膀胱癌糖酵解和乳酸分泌的功能与机制研究
Xiaojing Wang,Peipei Zhang,Jiaqi Yan et al.
Xiaojing Wang et al.
Background: Aberrant interplay between epigenetic reprogramming and metabolic rewiring events contributes to bladder cancer progression and metastasis. How the deacetylase Sirtuin-6 (SIRT6) regulates glycolysis and lactat...
The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane [0.03%]
尼曼匹克C1胆固醇转运蛋白失活通过降低ACE2在质膜上的丰度限制SARS-CoV-2进入宿主细胞
Piergiorgio La Rosa,Jessica Tiberi,Enrico Palermo et al.
Piergiorgio La Rosa et al.
Background: The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/Ly) that is involved in the mobilization of endocytosed cholesterol. Loss-of-function mu...