Plectin, a novel regulator in migration, invasion and adhesion of ovarian cancer [0.03%]
粘蛋白1是卵巢癌迁移、浸润和黏附的新调节因子
Lanning Bai,Xueqian Qian,Hui Zhang et al.
Lanning Bai et al.
Background: Ovarian cancer (OC) is one of the most prevalent gynecologic malignancies and exhibites the highest fatality rate among all gynecologic malignancies. The absence of an early diagnostic biomarker and therapeuti...
Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability [0.03%]
Epsin3通过调节EGFR稳定性促进非小细胞肺癌进展
Huiling Su,Jie Shen,Chenzi Gao et al.
Huiling Su et al.
Background: The abnormal expression and overactivation of the epidermal growth factor receptor (EGFR), a typical cancer marker for non-small cell lung cancer (NSCLC), are closely related to the tumorigenesis and progressi...
Classifications of triple-negative breast cancer: insights and current therapeutic approaches [0.03%]
三阴性乳腺癌的分类及其治疗手段
Ziqi Chen,Yumeng Liu,Minchuan Lyu et al.
Ziqi Chen et al.
Triple-negative breast cancer (TNBC) is an aggressive and challenging type of cancer, characterized by the absence of specific receptors targeted by current therapies, which limits effective targeted treatment options. TNBC has a high risk ...
Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization [0.03%]
臂丛神经撕脱损伤诱导的神经病理性疼痛及中枢敏化相关离子转运体KCC2的作用
Hang Xian,Huan Guo,Yuan-Ying Liu et al.
Hang Xian et al.
Lack in understanding of the mechanism on brachial plexus avulsion (BPA)-induced neuropathic pain (NP) is the key factor restricting its treatment. In the current investigation, we focused on the nociceptor-localized K+-Cl- cotransporter 2 ...
Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway [0.03%]
靶向SHIP/AKT途径改善Werner综合征干细胞的早衰现象
Hei-Yin Tam,Jiaxing Liu,Tsz-Ching Yiu et al.
Hei-Yin Tam et al.
Background: Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). WRN is known to protect somatic cells including adult stem cells from premature senescence. Loss of WRN ...
Jinling Tang,Kunzhao Du
Jinling Tang
In recent years, mitochondrial DNA (mtDNA) base editing systems have emerged as bioengineering tools. DddA-derived cytosine base editors (DdCBEs) have been developed to specifically induce C-to-T conversion in mtDNA by the fusion of sequenc...
TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3 [0.03%]
双特异性蛋白磷酸酶3通过TC2N的阻滞加速肺部癌变并保持干细胞特性
Jing Gu,Yang-Fan Lv,Ji-Ying Xia et al.
Jing Gu et al.
Background: Tandem C2 domains, nuclear (TC2N) is a protein that has been characterized to contain C2A domain, C2B domain, and a short C-terminus with a WHXL motif. In previous studies, we have uncovered the oncogenic role...
Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis [0.03%]
以谷氨酰胺-谷氨酸代谢作为治疗日本脑炎病毒引起脑炎的潜在靶点
Mengyuan Li,Hang Yuan,Xiaofei Yang et al.
Mengyuan Li et al.
Background: Japanese encephalitis (JE) induced by Japanese encephalitis virus (JEV) infection is the most prevalent diagnosed epidemic viral encephalitis globally. The underlying pathological mechanisms remain largely unk...
Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity [0.03%]
基于总量甲基化的空间去卷积确定肿瘤内的表观遗传异质性
Binbin Liu,Yumo Xie,Yu Zhang et al.
Binbin Liu et al.
Background: Intratumoral heterogeneity emerges from accumulating genetic and epigenetic changes during tumorigenesis, which may contribute to therapeutic failure and drug resistance. However, the lack of a quick and conve...
Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers [0.03%]
精子携带的小非编码RNA：作为表观遗传载体的潜在功能和机制
Muhammad Naveed,Zhaokang Shen,Jianqiang Bao
Muhammad Naveed
Over the past two decades, the study of sperm-borne small non-coding RNAs (sncRNAs) has garnered substantial growth. Once considered mere byproducts during germ cell maturation, these sncRNAs have now been recognized as crucial carriers of ...