Whole-genome bisulfite sequencing of cell-free DNA unveils age-dependent and ALS-associated methylation alterations [0.03%]
无细胞DNA的全基因组亚硫酸盐测序揭示了与年龄相关和ALS相关的甲基化改变
Yulin Jin,Karen N Conneely,Wenjing Ma et al.
Yulin Jin et al.
Background: Cell-free DNA (cfDNA) in plasma carries epigenetic signatures specific to tissue or cell of origin. Aberrant methylation patterns in circulating cfDNA have emerged as valuable tools for noninvasive cancer dete...
Naomi Borghini,Mirca Lazzaretti,Paolo Lunghi et al.
Naomi Borghini et al.
Proteoglycans are an ample family of complex extracellular matrix/cell surface components known to impact on virtually all biological processes that take place during life of a human being, in its healthy and diseased conditions. They are c...
Enpp1 ameliorates MAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathway [0.03%]
ENPP1通过AMPK/PPARα信号通路调节肝细胞脂质代谢从而缓解MAFLD
Xiaohui Liu,Shuai Chen,Xing Liu et al.
Xiaohui Liu et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the leading chronic liver disease globally, and there are no approved pharmacotherapies to treat this disease. Ectonucleotide pyrophospha...
KAT8 catalyzes the acetylation of SEPP1 at lysine 247/249 and modulates the activity of CD8+ T cells via LRP8 to promote anti-tumor immunity in pancreatic cancer [0.03%]
KAT8催化SEPP1在赖氨酸247/249处的乙酰化并通过LRP8调节CD8+ T细胞的活性以促进胰腺癌的抗肿瘤免疫
Zhongfei Zhu,Gang Nie,Xiaobo Peng et al.
Zhongfei Zhu et al.
Background: Pancreatic cancer (PC) remains one of the most lethal malignancies with unfavorable prognosis globally. Bioinformatics analysis predicted that SEPP1 was low expressed in PC and related to tumor immune microenv...
The lncRNA MIR181A1HG in extracellular vesicles derived from highly metastatic colorectal cancer cells promotes liver metastasis by remodeling the extracellular matrix and recruiting myeloid-derived suppressor cells [0.03%]
来自高转移性结直肠癌细胞的胞外囊泡中的长非编码RNA MIR181A1HG通过重塑细胞外基质和招募髓源性抑制细胞来促进肝转移
Yichao Gu,Yushuai Mi,Yifan Cao et al.
Yichao Gu et al.
Background: Colorectal liver metastasis (CRLM) is the main cause of death in colorectal cancer (CRC) patients worldwide. In the initial stage of metastasis, primary tumors provide the necessary conditions for metastasis b...
CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury [0.03%]
circRNA Itm2b通过与Sirt1-Nox4的相互作用诱导氧化应激，加剧创伤性脑损伤后的睡眠紊乱
Jiayuanyuan Fu,Mengran Du,Biying Wu et al.
Jiayuanyuan Fu et al.
Sleep disorders (SD) are common sequelae following traumatic brain injury (TBI) and may be linked to mitochondrial oxidative stress dysregulation after TBI. Increasing evidence showed that circRNAs play crucial roles in nervous system disea...
Ying Hu,Tahereh Setayesh,Dongguang Wei et al.
Ying Hu et al.
Background: The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with tox...
Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities [0.03%]
全基因组关联研究揭示了不同民族间与台湾人群脂肪肝指数相关的遗传危险因素（共享和特定的）
Pei Pei Lau,Chun-Yu Wei,Min-Rou Lin et al.
Pei Pei Lau et al.
Background and objectives: Although the incidence of fatty liver disease (FLD) is increasing worldwide, the genetic basis of this disease is not fully understood. This study uses the fatty liver index (FLI) to identify an...
Comparison of characteristics and immune responses between paired human nasal and bronchial epithelial organoids [0.03%]
人鼻和气管类器官的特性及免疫反应的对比分析
Lu Zhu,Wenhao Yang,Jiaxin Luo et al.
Lu Zhu et al.
Background: The nasal epithelium, as part of a continuous and integrated airway epithelium, provides a more accessible sample source than the bronchial epithelium. However, the similarities and differences in gene express...
Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures [0.03%]
恶性胆道狭窄中细胞外环状DNA的全面图谱及其致癌作用
Zhuo Cheng,Xuanmei Luo,Wenzheng Liu et al.
Zhuo Cheng et al.
Background: Extrachromosomal circular DNA (eccDNA) is crucial for carcinogenesis and bile has direct contact with malignant biliary strictures, yet eccDNA features in bile and its function in malignant biliary strictures ...