Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation [0.03%]
聚集素缺乏通过内质网应激和NLRP3炎性体激活加重胆汁淤积性肝病
Hye-Young Seo,Ji Yeon Park,So-Hee Lee et al.
Hye-Young Seo et al.
Background: Cholestatic liver disease, characterized by impaired bile flow, leads to the accumulation of harmful metabolites and toxins, resulting in liver damage. Inflammatory cytokines are crucial for the progression of...
Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis [0.03%]
盘虫属和假旋盘虫的丝氨酸蛋白酶抑制剂的结构及抑制活性比较研究
Ruixue Li,Bing Zhang,Chen Chen
Ruixue Li
Background: Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors sec...
Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: exploring sphingolipids in MASH-HCC progression [0.03%]
转录组学、脂质组学和单核RNA测序整合：探究MASH-HCC进展中的鞘脂类化合物
Jing Zeng,Grayson Way,Nan Wu et al.
Jing Zeng et al.
Background & aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses various conditions, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. M...
Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway [0.03%]
革兰氏阳性益生菌通过抑制亮氨酸和Hippo-YAP通路改善对乙酰氨基酚诱导的肝毒性
Wenkang Gao,Gang Wang,Hang Yuan et al.
Wenkang Gao et al.
Objectives: Drug-induced liver injury (DILI) can be improved by modulating gut microbiota. We aimed to investigate a probiotic mixture comprising Bifidobacterium Longum, Streptococcus thermophilus, and Lactobacillus delbr...
The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer [0.03%]
RNA结合蛋白CARHSP1通过增强前列腺癌中IL-17RAmRNA的稳定性来促进肿瘤生长，转移和免疫逃逸
YiFan Jiang,Yanan Wang,KaiHua Xue et al.
YiFan Jiang et al.
Background: Calcium-regulated heat-stable protein 1 (CARHSP1) has been identified as a cold shock domain (CSD) protein family member, participating in the regulation of ribosomal translation, mRNA degradation, and the rat...
Canonical and non-canonical functions of the non-coding RNA component (TERC) of telomerase complex [0.03%]
端粒酶复合物非编码RNA组分(TERC)的规范与非规范功能
Chongwen Cao,Weiyi Gong,Yuanlong Shuai et al.
Chongwen Cao et al.
The telomerase complex consists of a protein component (TERT), which has reverse transcriptase activity, and an RNA component (TERC), which serves as a template for telomere synthesis. Evidence is rapidly accumulating regarding the non-cano...
Shun Chang,Jiang Tan,Ren Bao et al.
Shun Chang et al.
Eukaryotic somatic cells undergo continuous telomere shortening because of end-replication problems. Approximately 10%~15% of human cancers rely on alternative lengthening of telomeres (ALT) to overcome telomere shortening. ALT cells are ch...
Altered synaptic homeostasis: a key factor in the pathophysiology of depression [0.03%]
改变的突触稳态：抑郁症病理生理学中的关键因素
Bokai Wang,Teng He,Guofan Qiu et al.
Bokai Wang et al.
Depression, a widespread psychiatric disorder, is characterized by a diverse array of symptoms such as melancholic mood and anhedonia, imposing a significant burden on both society and individuals. Despite extensive research into the neurob...
Enhanced exosome secretion regulated by microglial P2X7R in the medullary dorsal horn contributes to pulpitis-induced pain [0.03%]
牙髓炎所致疼痛与中脑后角的小胶质细胞P2X7R调控的胞外囊泡分泌增强有关
Jing Zhang,Zhuo Yu,Mingjun Wang et al.
Jing Zhang et al.
Background: Pulpitis is a prevalent oral disease characterized by severe pain. The activation of microglia in the medullary dorsal horn (MDH) is reportedly essential for the central sensitization mechanism associated with...
The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes [0.03%]
m6A革命：转变肿瘤免疫并增强免疫治疗效果
Tongguo Shi,Huan Zhang,Yueqiu Chen
Tongguo Shi
N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, plays a critical role in the development and progression of various diseases, including cancer, through its regulation of RNA degradation, stabilization, splicing,...