The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8 [0.03%]
RBM39降解剂Indisulam通过改变ZMYND8的可变剪接抑制急性巨核细胞白血病
Ying Yang,Zhiheng Li,Yang Yang et al.
Ying Yang et al.
Background: Acute megakaryoblastic leukemia (AMKL) is a rare hematological malignancy in adults but children. Alternative splicing (AS) has been shown to affect hematological cancer progression, making splicing factors pr...
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer's disease [0.03%]
阿尔茨海默病小鼠模型中mRNA的ac4C修饰失调
Hao-Nan Ji,Hai-Qian Zhou,Jing-Bo Qie et al.
Hao-Nan Ji et al.
Background: The identification and intervention of Alzheimer's Disease (AD) in its early-stage allows for the timely implementation of lifestyle modifications and therapeutic strategies. Although dysregulation of protein ...
Jia Liu,Changmeng Li,Yun Yang et al.
Jia Liu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic and systemic metabolic liver disease characterized by the presence of hepatic steatosis and at least one cardiometabolic risk factor (CMRF). The pathogenesis of M...
The influence of SARS-CoV-2 spike protein exposure on retinal development in the human retinal organoids [0.03%]
SARS-CoV-2刺突蛋白接触对人视网膜类器官视网膜发育的影响
Jing Gong,Lingling Ge,Yuxiao Zeng et al.
Jing Gong et al.
Background: Pregnant women are considered a high-risk population for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as the virus can infect the placenta and embryos. Recently, SARS-CoV-2 has been ...
Shared and distinct peripheral blood immune cell landscape in MCTD, SLE, and pSS [0.03%]
MCTD、SLE和pSS中免疫外周血单个核细胞的比较研究
Yanling Cui,Huina Zhang,Yaxuan Deng et al.
Yanling Cui et al.
Background: Mixed connective tissue disease (MCTD) is a rare autoimmune disease, and little is known about its pathogenesis. Furthermore, MCTD, systemic lupus erythematosus (SLE), and primary Sjögren's syndrome (pSS) sha...
A review of the 661W cell line as a tool to facilitate treatment development for retinal diseases [0.03%]
661W细胞系在视网膜疾病治疗研究中的应用及展望综述
Alicia A Brunet,Rebekah E James,Petria Swanson et al.
Alicia A Brunet et al.
Retinal diseases encompass a diverse group of disorders that affect the structure and function of the retina, leading to visual impairment and, in some cases, irreversible vision loss. The investigation of retinal diseases is crucial for un...
Loss of OBSCN expression promotes bladder cancer progression but enhances the efficacy of PD-L1 inhibitors [0.03%]
OBSCN表达的丢失促进膀胱癌的发展但增强PD-L1抑制剂的功效
Tao Wang,Tuanjie Guo,Juanjuan Sun et al.
Tao Wang et al.
Background: As the objective overall response rate to immune checkpoint inhibitors (ICIs) is less than 30% in late stage or metastatic bladder cancer (BLCA), elucidating the intrinsic mechanisms of immune evasion is of gr...
Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility [0.03%]
人类ABCC4识别cAMP及其配体识别弹性的结构基础
Xuepeng Wen,Kaixue Si,Dantong Zhu et al.
Xuepeng Wen et al.
Background: ABCC4 (ATP-binding cassette sub-family C member 4) is a transporter protein that is primarily localized to the plasma membrane, and its efflux activity is associated with the progression of various cancers and...
Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer's mouse models [0.03%]
神经元CD47诱导行为改变并改善野生型和阿尔茨海默病小鼠模型的的小胶质细胞突触修整功能
Wenjie Hu,Mengting Chen,Yuxue Lin et al.
Wenjie Hu et al.
Background: Microglia are brain-resident macrophages that play a crucial role in synapse pruning during the development and progression of various neuropsychiatric disorders, including autism spectrum disorder (ASD) and A...
Correction: L-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway [0.03%]
纠正：L-精氨酸，作为一种必需氨基酸，可能是通过调节ROS / NLRP3 / NF-κB信号通路治疗COPD的潜在替代品
Chunhua Ma,Kexi Liao,Jing Wang et al.
Chunhua Ma et al.
Published Erratum
Cell & bioscience. 2025 Mar 17;15(1):37. DOI:10.1186/s13578-025-01373-2 2025