Biological function of RNA-binding proteins in myocardial infarction: a potential emerging therapeutic limelight [0.03%]
RNA结合蛋白在心肌梗死中的生物学功能：潜在的新兴治疗亮点
Chenyang Jin,Yutong Ye,Longzhe Gao et al.
Chenyang Jin et al.
Myocardial infarction (MI) is currently one of the most fatal cardiovascular diseases worldwide. The screening, treatment, and prognosis of MI are top priorities for cardiovascular centers globally due to its characteristic occult onset, hi...
Comprehensive analysis of the critical role of the epithelial mesenchymal transition subtype - TAGLN-positive fibroblasts in colorectal cancer progression and immunosuppression [0.03%]
全面分析上皮间充质转化亚型-TAGLN阳性成纤维细胞在结直肠癌进展和免疫抑制中的关键作用
Junli Zhang,Xinxin Jin,Yachao Hou et al.
Junli Zhang et al.
Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor metastasis and immune suppression in colorectal cancer (CRC). However, the specific mechanisms of EMT and its relationship with the clinical prognosis and immunotherapy r...
Hypoxia-ischemia and sexual dimorphism: modeling mitochondrial dysfunction using brain organoids [0.03%]
脑缺氧-缺血与性别二态性：使用人脑类器官模拟线粒体功能障碍
Romane Gaston-Breton,Clémence Disdier,Henrik Hagberg et al.
Romane Gaston-Breton et al.
Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neurodevelopmental morbidities in full-term infants. There is strong evidence of sexual differences in hypoxic-ischemic (HI) injury where male neonates are at higher risk as they a...
Intermittent fasting and metabolic dysfunction-associated steatotic liver disease: the potential role of the gut-liver axis [0.03%]
间歇性禁食与代谢功能障碍相关脂肪肝病：肠道-肝脏轴的潜在作用
Zhaoxi Zhang,Alice Pik-Shan Kong,Vincent Wai-Sun Wong et al.
Zhaoxi Zhang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern linked to the increasing prevalence of metabolic syndrome, including obesity and type 2 diabetes (T2D). MASLD remains a significant clinical...
Tie2-expressing monocytes/macrophages promote angiogenesis in chronically ischaemic brain tissue [0.03%]
Tie2表达单核细胞/巨噬细胞促进慢性缺血性脑组织的血管生成
Chuyang Tai,Cong Ling,Yang Yang et al.
Chuyang Tai et al.
Background: Over half of patients with chronically ischaemic cerebrovascular disease (CICD) exhibit poor revascularization potential. Tie2-expressing monocytes/macrophages (TEMs) have been reported to promote angiogenesis...
The HNRNPC/CELF2 signaling pathway drives glycolytic reprogramming and mitochondrial dysfunction in drug-resistant acute myeloid leukemia [0.03%]
HNRNPC/CELF2信号通路驱动药物耐药急性髓系白血病的代谢重编程及线粒体功能障碍
Xiang Ma,Haodong Li,Ziqi Zhao et al.
Xiang Ma et al.
Background: Acute myeloid leukemia (AML) is an aggressive cancer with high treatment resistance, often leading to poor patient outcomes. Metabolic reprogramming plays a critical role in AML progression, influencing drug r...
Characterization and prognostic of CD8 + TIM3 + CD101 + T cells in glioblastoma multiforme [0.03%]
胶质母细胞瘤中CD8+TIM3+CD101+T细胞的特征及预后研究
Hong-Liang Wang,Sai Li,Chun-Chun Ma et al.
Hong-Liang Wang et al.
Background: Glioblastoma multiforme (GBM) is a pervasive and aggressive malignant brain tumor. In the tumor immune microenvironment, CD8 + TIM3 + CD101 + T cells (CCT cells) play a pivotal role in tumor progression and im...
Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPARγ [0.03%]
CAV2通过转录抑制PPARγ干扰OSCC中的脂质稳态引发凋亡、脂解和线粒体功能障碍
Yuting Bai,Mingjing Jiang,Xiaojie Chen et al.
Yuting Bai et al.
Background: Abnormal lipid droplet (LD) dynamics in oral squamous cell carcinoma (OSCC) indicate lipid metabolism alterations that facilitate malignancy progression. However, the specific mechanisms by which disruptions i...
FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion [0.03%]
FTO下调介导的m6A修饰导致肝细胞癌侵袭增强
Cheng Zhou,Yong Zhang,Shi-Ming Shi et al.
Cheng Zhou et al.
Background: Dysregulation of N6-methyladenosine (m6A) modifications has been implicated in various cancers, including hepatocellular carcinoma (HCC). This study aimed to elucidate the role of m6A modifications in HCC prog...
The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases [0.03%]
G蛋白偶联受体信号通路在B细胞分化发育中的调控功能及其在自身免疫病中的作用机制研究
Yongqi Shao,Yang Mei,Yixin Tan et al.
Yongqi Shao et al.
Autoimmune diseases are characterized by a dysfunction of the immune system. Disruptions in the balance of B-cell dynamics and the increase in auto-antibody levels are pivotal in the triggering of several autoimmune disorders. All of this i...