WNT3 promotes chemoresistance to oxaliplatin in oral squamous cell carcinoma via regulating ABCG2 expression [0.03%]
WNT3通过调节ABCG2表达促进口腔鳞状细胞癌对奥沙利铂的耐药性
Kairui Sun,Xuyang Zhang,Ruihuan Gan et al.
Kairui Sun et al.
Oxaliplatin (OXA) is a frontline therapeutic agent used in the treatment of oral squamous cell carcinoma (OSCC). However, the development of chemoresistance has emerged as a significant challenge, compromising the effectiveness of treatment...
Domain acquisition enabled functional expansion of the TFIIS transcription factor family [0.03%]
真核生物中TFIIS转录因子家族的功能扩张及其结构基础研究
Kateryna Matveyeva,Ainhoa Sánchez de Diego,María Ángeles García-López et al.
Kateryna Matveyeva et al.
TFIIS and its homologs were long considered a delimited family of transcription factors, for the ability to induce RNA Polymerase II backtracking and nascent RNA cleavage. Recent studies however show that the relevant domains, which corresp...
Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation [0.03%]
HOIP介导的p31Comet线性泛素化连接细胞因子信号与有丝分裂调控
Yifeng Gao,Qing Yin,Yaser Gamallat et al.
Yifeng Gao et al.
Background: Inflammation and genomic instability are among the hallmarks of human cancer. Proinflammatory cytokines induce DNA damage through the accumulation of reactive oxygen and nitrogen species (RONS), which often le...
Novel roles for CREG1 in hematopoiesis revealed by single-cell RNA sequencing [0.03%]
单细胞RNA测序揭示CREG1在造血中的新作用
Xiao Han,Keliang Pang,Xiaohui Liu et al.
Xiao Han et al.
Background: Hematopoiesis, the process of generating diverse blood cell lineages, is essential for maintaining organismal homeostasis and survival. CREG1 has been implicated in various cellular processes, including prolif...
Chemically defined and xeno-free media enables the derivation of human extended pluripotent stem cell lines from discarded blastocysts with a high efficiency [0.03%]
化学成分明确及不含异种成分的培养液可高效诱导废弃囊胚至人扩展多能干细胞阶段
Zhuran Zhao,Xi Chen,Shan Wang et al.
Zhuran Zhao et al.
Human extended pluripotent stem cells (hEPS) had been reported to be derived from discarded blastocysts, whereas the derivation method of hEPS cells was extremely complex in this protocol with feeder and animal serum conditions, which also ...
Hippocampal CA1 neuron, a crucial regulator for chronic stress exacerbating Alzheimer's disease progression [0.03%]
海马CA1神经元在慢性应激促进阿尔茨海默病进展中的关键作用
Qing-Lin Gao,Hai-Wei Zha,Zi-Jie Liu et al.
Qing-Lin Gao et al.
Chronic stress, a common risk factor for psychiatric disorders, is also implicated in the pathogenesis of Alzheimer's disease (AD). However, its underlying mechanisms remain elusive. Here, we provide evidence for chronic restraint stress (C...
Rab11a-dependent recycling of Glut3 inhibits seizure-induced neuronal disulfidptosis by alleviating glucose deficiency [0.03%]
Rab11a依赖的Glut3回循环通过缓解葡萄糖缺乏抑制癫痫引起的神经硫缺病
Sijun Li,Junrui He,Huimin Kuang et al.
Sijun Li et al.
Seizures can trigger neuronal glucose deficiency, thereby inducing disulfidptosis. Disulfidptosis is a novel cell death mechanism characterized by the abnormal accumulation of disulfide caused by glucose deficiency. However, the mechanism u...
Shedding light on the cell biology and diverse physiological functions of the migrasome [0.03%]
揭秘迁徙体的细胞生物学及其多种生理功能
Yuxing Huang,Yi Huang,Jian Gao
Yuxing Huang
The migrasome, an organelle that forms behind migrating cells, is connected to the cell body by a retraction fiber. Once released from the retraction fiber, the migrasome transforms into an extracellular vesicle and plays important roles in...
Emerging roles of ribosome translation in stem cells and stem cell therapy - a review [0.03%]
核糖体翻译在干细胞及其治疗中的新兴作用-综述文章
Yanyan Gao,Linlin Guo,Gaoxiang Shi et al.
Yanyan Gao et al.
Stem cells differ from other somatic cells in that they possess self-renewal and differentiation potential, which endows them with unique characteristics, and have great therapeutic potential. Studies have shown that the self-renewal and di...
Role of ZBED3 in PALD1/PIP2- dependent calcium homeostasis during oocyte maturation [0.03%]
ZBED3在PALD1/PIP2依赖的卵母细胞成熟过程中钙稳态中的作用
Danyu Ni,Qijun Xie,Yuting Chen et al.
Danyu Ni et al.
Zinc Finger BED-Type Containing 3 (ZBED3) had been shown to be a novel component of the subcortical maternal complex (SCMC). In previous reports, ZBED3 depletion leads to asymmetric zygotic division and aberrant distribution of organelles i...