FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep [0.03%]
Lanping黑山羊的FRRS1L变异和铁蛋白血红素过载导致色素沉着和全身性铁过载
Deping Han,Yuanyuan Zhang,Weidong Deng et al.
Deping Han et al.
Background: Hemoglobin metabolism disorder can result in systemic iron overload, leading to pigmentation in multiple organs. Although these disorders are often of genetic origin, the specific genes and mechanisms remain i...
Lulin Ma,Yaoling Wang,Yi Zhao et al.
Lulin Ma et al.
Chronic pain has a serious impact on the quality of patients' life. Currently, the mechanism of chronic pain has not been fully studied, and the treatments are often ineffective. Abnormal glucose metabolism plays an important role in the oc...
Programmed cell death in the cognitive impairment of obstructive sleep apnea [0.03%]
阻塞性睡眠呼吸暂停认知障碍中的细胞凋亡程序化死亡
Yanru Ou,Xiufang Wang,Dandan Zong et al.
Yanru Ou et al.
Cognitive impairment (CI) is a significant and extraordinary complication of obstructive sleep apnea (OSA) patients. Programmed cell death (PCD) is an active and ordered process regulated by genes. A growing number of studies find that PCD ...
Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC [0.03%]
利用CRISPR-SONIC进行位点特异性致癌基因插入的小鼠自发HPV阳性口腔癌症模型的建立
Julia Tao,Jason Murray,Hsin-Fang Tu et al.
Julia Tao et al.
Human papillomavirus associated head and neck cancer (HPV + HNC) is rising globally, emphasizing the need for improved therapeutic and screening strategies. To test novel therapies and study HPV-related disease progression, it is vital to d...
The indispensable role of Mediator complex subunit 27 during neurodevelopment [0.03%]
中介体复合物亚基27在神经发育中的重要作用
Xiaocheng Li,Nuermila Yiliyaer,Tianyu Guo et al.
Xiaocheng Li et al.
Background: MED27 is a subunit of the Mediator complex, a highly conserved protein assembly that initiates transcription by bridging transcription factors bound at enhancers to RNA polymerase II transcription machinery at...
Alpha fetoprotein (AFP)-producing gastric cancer: clinicopathological features and treatment strategies [0.03%]
产生甲胎蛋白(AFP)的胃癌的临床病理特征和治疗策略
Bixian Luo,Zelai Wu,Chengyu Hu et al.
Bixian Luo et al.
Alpha-fetoprotein (AFP) is a widely recognized tumor marker for hepatocellular carcinoma and yolk sac tumors. Alpha-fetoprotein-producing gastric cancer (AFPGC) is a rare but highly malignant subtype of gastric cancer associated with poor p...
Cilia at the crossroad: convergence of regulatory mechanisms to govern cilia dynamics during cell signaling and the cell cycle [0.03%]
纤毛在信号转导和细胞周期中的动态调控机制 convergent or divergent?
Lukáš Čajánek,Sindija Smite,Olha Ivashchenko et al.
Lukáš Čajánek et al.
Cilia are versatile, microtubule-based organelles that facilitate cellular signaling, motility, and environmental sensing in eukaryotic cells. These dynamic structures act as hubs for key developmental signaling pathways, while their assemb...
Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner [0.03%]
性二向性的烷基甘油单氧化酶通过抑制白三烯和前列腺素生物合成来调节炎症反应
Zhigang Rao,Katharina Lackner,Ilaria Dorigatti et al.
Zhigang Rao et al.
Background: Ether lipids are important constituents of biological membranes and harbor fatty alcohols attached via ether linkages to the sn-1 position of the glycerol backbone. Depending on the nature of the ether bond, t...
Post-translational modifications in the pathophysiological process of metabolic dysfunction‑associated steatotic liver disease [0.03%]
代谢功能障碍相关脂肪性肝病病理生理过程中的翻译后修饰
Yiyang Min,Yiqiao Zhang,Yu Ji et al.
Yiyang Min et al.
In recent years, the prevalence of metabolic dysfunction‑associated steatotic liver disease (MASLD), which was called non-alcoholic fatty liver disease (NAFLD), has been progressively increasing in populations. The progression of MASLD enc...
Jiewen Wang,Mingjing Peng,Linda Oyang et al.
Jiewen Wang et al.
Lactate is a crucial product of cancer metabolism, creating an acidic environment that supports cancer growth and acts as a substrate for lactylation. Lactylation, a newly discovered epigenetic modification, plays a vital role in cancer cel...