Cerebrovascular-mediated dynamic alterations in neurovascular coupling: a key pathological mechanism of depression [0.03%]
脑血管介导的神经血管耦合动态改变：抑郁症的关键病理机制
Xiaoyun Yang,Jiaxin Wang,Jiahao Zhang et al.
Xiaoyun Yang et al.
Neurovascular coupling (NVC) is a vital regulatory mechanism that synchronizes neural activity with vascular responses to support brain function. Although the precise mechanisms of NVC remain incompletely elucidated, its dysfunction is incr...
Cytoskeleton disruption and plasma membrane damage determine methuosis of normal and malignant cells [0.03%]
细胞骨架瓦解和质膜损伤决定正常和恶性细胞的甲硫胺素形成
Bin Dong,Jing Xiao,Junqi Wang et al.
Bin Dong et al.
Background: Methuosis represents a novel cell death modality characterized by catastrophic cytoplasmic vacuolization in normal and malignant cells. However, the critical role and the underlying mechanism of cytoskeleton a...
Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancer [0.03%]
胆固醇通过赋予阿帕替尼介导的胃癌细胞铁死亡抵抗而促进胃癌发展
Zhiwei Li,Chenxin Liu,Minghao Wang et al.
Zhiwei Li et al.
Background: Gastric cancer is the fifth leading cause of cancer-related deaths worldwide. Apatinib is a third-line treatment for gastric cancer. However, the development of resistance significantly limits its efficacy, an...
Genomic ncRNAs regulating mitochondrial function in neurodegeneration: a neglected clue in the complex etiopathogenesis of multiple sclerosis [0.03%]
基因组ncRNA在神经退行性疾病中的线粒体功能调控作用：一个多发性硬化症复杂发病机制中的未解线索
Nima Sanadgol,Mahedeh Samadi,Clara Voelz et al.
Nima Sanadgol et al.
Multiple sclerosis (MS), the most prevalent myelinopathy with unclear etiology, involves mitochondrial dysfunction that critically contributes to oligodendrocyte damage and neurodegeneration. Recent interest has surged around the role of in...
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis [0.03%]
锌指蛋白146通过MDM2/p53和PHGDH/铁死亡加速肺腺癌进展
Junkan Zhu,Shencheng Ren,Yanjun Yi et al.
Junkan Zhu et al.
Background: Lung adenocarcinoma (LUAD) remains a significant contributor to cancer incidence and mortality, with transcription factors playing pivotal roles in its progression and serving as potential therapeutic targets....
ebv-sisRNA-3 contributes to the formation of G4-associated R-loop upstream of EBV lytic replication origin in latently infected cells [0.03%]
EB病毒 sisRNA-3有助于形成G4相关的发卡结构上游的EB病毒潜伏感染细胞的裂解复制起源区域
Bo Wang,Grace Tin Yun Chung,Yi Shuai et al.
Bo Wang et al.
Background: In EBV-associated epithelial cancers, only a limited number of viral proteins are translated, while multiple EBV-encoded non-coding RNAs are expressed to minimize activation of the host's immune response. Thes...
Single-cell and spatial analyses of the GDF family in tumors, with a focus on the prognostic and biological role of GDF15 in hepatocellular carcinoma [0.03%]
GDF家族肿瘤单细胞和空间组学分析及其成员GDF15在肝癌预后和生物学中的作用研究
Xiaoqian Feng,Qian Huai,Fumin Zhang et al.
Xiaoqian Feng et al.
Growth differentiation factors (GDFs) are a subfamily of the TGF-β superfamily whose expression increases in response to cellular stress and disease. Despite emerging cell- or animal-based evidence supporting an association between the GDF...
Correction: Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes [0.03%]
纠正：单核RNA测序揭示了自发性早产亚型中胎盘滋养层特征的区别生理病理标志
Cherilyn Uhm,Jianlei Gu,Weina Ju et al.
Cherilyn Uhm et al.
Published Erratum
Cell & bioscience. 2025 Jun 26;15(1):90. DOI:10.1186/s13578-025-01421-x 2025
Kv1.1 channel dysfunction in parvalbumin-positive interneurons contributes to anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout mice [0.03%]
老年素1/2条件性双敲除小鼠parvalbumin阳性中间神经元Kv1.1通道功能障碍参与年轻成年期焦虑样行为异常表型的产生
Guang Yang,Yang Zhao,Chenyi Zhao et al.
Guang Yang et al.
Anxiety occurs in the early stage of cognitive disorders, which can exacerbate cognitive impairment. However, the pathogenesis of this kind of anxiety remains unclear. In this study, we investigated anxiety-like behaviors in young adult pre...
The human testis-specific protein Y-linked (TSPY) is a male-specific cancer-testis antigen capable of eliciting significant immune responses and elimination of positive tumor cells in hepatocellular carcinoma [0.03%]
人Y染色体特异性蛋白（TSPY）是一种男性特有的癌睾抗原，能够引起显著的免疫反应并消除肝细胞癌中的阳性肿瘤细胞
Tatsuo Kido,Yun-Fai Chris Lau
Tatsuo Kido
The testis-specific protein Y-linked (TSPY) is a male-specific cancer-testis antigen specifically expressed in germ cells of the testis under normal conditions and various cancers, particularly in hepatocellular carcinoma (HCC), under oncog...