Yun-Fai Chris Lau
Yun-Fai Chris Lau
Mosaic loss of Y chromosome is a common genetic phenomenon in elderly men. It predisposes affected individuals to cancers, suggesting that genes on this male-specific chromosome contribute to the well-being of men. Currently, the putative g...
Astrocytic VPS35 coordinates iron homeostasis with HIF1α-VEGFa signaling to prevent astrocytic ferroptosis and to promote neocortical angiogenesis [0.03%]
天星VPS35通过与HIF1α-VEGFa信号协调铁稳态来预防天星铁依赖性细胞死亡(ferroptosis)并促进 neo-cortical血管生成
Anika Wu,Daehoon Lee,Ananya Nadgauda et al.
Anika Wu et al.
Astrocytes coordinate neuronal activity with vascular development and metabolic homeostasis during postnatal brain maturation, yet the mechanisms enabling astrocytes to support angiogenesis remain elusive. VPS35, a core component of the ret...
Cellular prion protein and its derived peptides: multifaceted roles in neurodegenerative diseases and potential as biomarkers [0.03%]
细胞型朊蛋白及其衍生肽在神经退行性疾病中的多面作用及其作为生物标志物的潜力
Emanuela Mari,Michele Aventaggiato,Emanuela Paldino et al.
Emanuela Mari et al.
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and transmissible spongiform encephalopathies (TSEs), share fundamental mechanisms of protein misfolding, synaptic dysfunct...
Hepatocyte growth factor suppresses melanogenesis via ERK-dependent nuclear exclusion of MITF [0.03%]
肝细胞生长因子通过ERK依赖的MITF核排出抑制黑色素生成
Jeong Hyeon Lee,Jae Min Yoo,Youngsup Song et al.
Jeong Hyeon Lee et al.
Background: Hepatocyte growth factor (HGF) has been considered a promising candidate for improving skin and hair quality. Solar lentigines-the most common UV-associated hyperpigmentary skin disorder-have historically been...
Mitochondrial proteases maintain cellular protein homeostasis and tissue integrity [0.03%]
线粒体蛋白酶维持细胞蛋白质稳态和组织完整性
Kexin Shi,Hao Liu,Hong Xu et al.
Kexin Shi et al.
Background: Mitochondrial proteases are essential for mitochondrial protein import and constitute the core of the organelle's intrinsic protein quality control system. However, their physiological functions across tissues...
Unveiling a unique microglial phenotype promoting oxidation in the iBRB: insights from single-cell transcriptomics in the NPDR rat model [0.03%]
单细胞转录组揭示糖网大鼠模型中促进iBRB氧化的微胶质细胞表型
Yifei Geng,Yunqi Zhang,Xiaoyu Xu et al.
Yifei Geng et al.
Background: Early diagnosis and targeted treatment of inner blood-retinal barrier (iBRB) impairment in non-proliferative diabetic retinopathy (NPDR) present significant challenges. This study investigates the cellular het...
Aerobic exercise enhances α-tubulin lactylation and neurological recovery after ischemic stroke [0.03%]
有氧运动可改善缺血性脑卒中后的α-微管蛋白乳酸化及其神经功能恢复
Yun Zhang,Xianli Tang,Zeheng Li et al.
Yun Zhang et al.
Background: Ischemic stroke causes severe neurological disability, with some patients still presenting with residual neurological dysfunction. Aerobic exercise shows potential for post-stroke recovery. However, the mechan...
Environmental enrichment mitigates sevoflurane-induced neurodevelopmental injury via cGAS-STING-dependent microglial modulation [0.03%]
环境丰富通过cGAS-STING依赖的微胶质细胞调节减轻异氟烷引起的神经发育损伤
Feixiang Li,Bingqing Gong,Haiyan Wu et al.
Feixiang Li et al.
Background: Neonatal exposure to sevoflurane has been implicated in long-term neurodevelopmental abnormalities, yet the underlying mechanisms remain unresolved. This study sought to determine whether cGAS-STING-mediated m...
Correction: Dapagliflozin attenuates hypoxia/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK [0.03%]
Correction: 达格列净通过调节AMPK减轻缺氧/复氧引起的心脏功能障碍和氧化损伤
Kun-Ling Tsai,Pei-Ling Hsieh,Wan-Ching Chou et al.
Kun-Ling Tsai et al.
Published Erratum
Cell & bioscience. 2026 Jun 19;16(1):67. DOI:10.1186/s13578-026-01606-y 2026
CALR-dependent endoplasmic reticulum N-glycoprotein maturation promotes Japanese encephalitis virus entry and replication [0.03%]
CALR依赖的内质网N-糖蛋白成熟促进日本脑炎病毒进入和复制
Yonghui Zhang,Jinyan Zhang,Rui Jiang et al.
Yonghui Zhang et al.
The endoplasmic reticulum (ER) chaperone machinery participates in multiple stages of viral infection, from entry through assembly and release. However, how ER-resident quality-control mechanisms shape cellular permissiveness to Japanese en...