Monoclonal antibody passive experimental autoimmune myasthenia gravis: current progress and future directions [0.03%]
单克隆抗体被动实验性自身免疫重症肌无力的现状和未来方向
Liting Zheng,Jianghao Wang,Siying Tang et al.
Liting Zheng et al.
Experimental Autoimmune Myasthenia Gravis (EAMG) remains a cornerstone platform for mechanistic studies of pathogenic antibodies in myasthenia gravis (MG). In particular, monoclonal antibody passive-transfer EAMG (mAb-PTMG) has been instrum...
Cannabidiol enhances tamoxifen efficacy via CREB-mediated suppression of ERα signaling in ER-positive breast cancer cells [0.03%]
大麻二酚通过CREB介导的ERα信号传导抑制作用增强阳性乳腺癌细胞三苯氧胺疗效
Bu Gyeom Kim,Okhyeon Kim,Do-Yeon Lee et al.
Bu Gyeom Kim et al.
Background: Estrogen receptor alpha (ERα) plays a crucial role in the proliferation and survival of ER-positive breast cancer cells, and tamoxifen (TAM) remains the mainstay of endocrine therapy. However, acquired resist...
The transmembrane segments of SARS-CoV-2 nsp3 govern viral intracellular trafficking [0.03%]
SARS-CoV-2 nsp3的跨膜区段调控病毒胞内转运
Manqi Cao,Lang Qin,Huaan Zhang et al.
Manqi Cao et al.
After entry, coronaviruses deliver their genomic RNA to the ER-Golgi intermediate compartment to build replication organelles, yet how the RNA first contacts membranes is unclear. Here, we demonstrate that the first transmembrane helix of n...
LBH deficiency influences the therapeutic effects of regulatory B cells through the regulation of IL-10 production via the Rap1 pathway [0.03%]
LBH通过Rap1信号转导调控IL-10的产生从而影响调节性B细胞的治疗作用
Weijia Bao,Ke Hu,Yuan Qu et al.
Weijia Bao et al.
Regulatory B cells (Bregs) are immune cells that affect the autoimmune response by producing interleukin (IL)-10, but the molecular mechanism affecting Breg differentiation and IL-10 production is not clear. Our study found that mice with l...
Calpain cleaves the distal carboxyl terminus of TRPV1 and modulates its tachyphylaxis [0.03%]
钙蛋白酶剪切TRPV1的羧基末端并调节其快速适应性
Jin-Yan Jiang,Xiao-Chen Wang,Jing Yang et al.
Jin-Yan Jiang et al.
Background: Transient receptor potential vanilloid-1 (TRPV1) plays a critical role in noxious heat sensation in physiological conditions and pain hypersensitivity in pathological pain. Capsaicin, a classic TRPV1 agonist, ...
ESRG maintains human pluripotent stem cell self-renewal by binding NPM1 to regulate BMP4 protein and TGF-β signaling pathway [0.03%]
ESRG通过结合NPM1调节BMP4蛋白和TGF-β信号通路维持人类多能干细胞自我更新
Ziling Liao,Cong Zhao,Lei Wang et al.
Ziling Liao et al.
Human pluripotent stem cells (hPSCs) present considerable potential for regenerative medicine; however, the standardization and large-scale production of these cells are hindered by an incomplete understanding of the molecular mechanisms go...
BDNF-TrκB-PLCγ signaling drives BPA-induced mechanical allodynia through activating mechanosensitive Piezo2 channels [0.03%]
BDNF-TrκB-PLCγ信号通过激活机械敏感的Piezo2通道诱导双酚A引起的机械性痛觉过敏
Yuan-Ying Liu,Huan Guo,Hang Zhang et al.
Yuan-Ying Liu et al.
Background: Brachial plexus avulsion (BPA) induced neuropathic pain (NP) affects up to 90% patients with BPA, which is often characterized by mechanical allodynia. The gradual chronicity of the pain and the lack of effect...
Investigation of embryogenesis in a dish: the development and application of gastruloid models from pluripotent stem cells [0.03%]
用培养皿中的胚胎发育研究：多能干细胞来源的原肠胚样模型的发展与应用
Kexin Lin,Hanyumo Chen,Yuxin Chen et al.
Kexin Lin et al.
Gastrulation constitutes a critical phase of mammalian embryogenesis, during which the embryo undergoes morphological changes, germ layer determination, and body axes establishment, laying the foundation for subsequent embryonic development...
Key role of transcription factors network in proliferative vitreoretinal diseases development [0.03%]
转录因子网络在增殖性视网膜玻璃体疾病发生发展中的关键作用
Clément Duveau,Yosra Raiss El Harrak,Azine Datlibagi et al.
Clément Duveau et al.
Proliferative vitreoretinal diseases (PVDs) encompass severe ocular disorders such as proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy (PDR), and epiretinal membranes (ERM), characterized by the formation of fibrova...
Targeting the 5-HT1A receptor in the ventral hippocampus alleviates anxiety-like behavior in mice with angiotensin II-induced hypertension [0.03%]
靶向血管紧张素II诱导的高血压小鼠脑室海马体5-HT1A受体缓解焦虑样行为
Wenjun Chen,Zhoucai Luo,Mingfeng Huang et al.
Wenjun Chen et al.
Hypertension, a chronic condition, has affected > 1 billion people worldwide and is linked to a heightened risk of anxiety disorders. Despite this association, the exact mechanisms underlying the connections between hypertension and anxiety...