Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies [0.03%]
ZC3H15失活导致端粒酶困于高尔基体从而影响其维持端粒长度的功能
Chuanle Wang,Wei Chen,Ruofei Li et al.
Chuanle Wang et al.
Background: Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors. In human stem cells and approximately 8...
Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales's testis [0.03%]
单细胞RNA测序揭示了变性人的睾丸中支持细胞异常抬高和生精微环境损伤
Jun Yu,Longfei Hu,Huixia Li et al.
Jun Yu et al.
Background: Transgender women (transfemales) often undergo gender-affirming hormone therapy (GAHT). However, the testicular impacts of feminising hormones present heterogeneity due to the complexity of testicular regulato...
Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis [0.03%]
环状RNA Circ_HUWE1：动脉粥样硬化中脂质蓄积、炎症和肠道菌群的新型调节因子
Zulong Sheng,Yi Fan,Zhenjun Ji et al.
Zulong Sheng et al.
Background: Atherosclerosis (AS) is a chronic cardiovascular disease characterized by lipid accumulation and inflammation within arterial walls, leading to plaque formation and cardiovascular events. Circular RNAs (circRN...
Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1 [0.03%]
活性氧通过调节CCAAT/enhancer binding protein同源蛋白和醛酮还原酶家族1成员A1基因表达调控人间充质干细胞成骨分化方向(commitment)
Chen Hao Chiang,Yu-Chieh Kao,Yi-Hui Lin et al.
Chen Hao Chiang et al.
Background: Bone-derived mesenchymal stem cells (BMSCs) are multipotent stem cells capable of differentiating into adipocytes and osteoblasts. Dysfunctional differentiation, characterized by a shift from osteoblastogenesi...
The dual role of mTOR signaling in lung development and adult lung diseases [0.03%]
mTOR信号通路在肺发育和成人肺疾病中的双重作用
Jiahui Bao,Wenjing Bao,Yajie Song et al.
Jiahui Bao et al.
Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia [0.03%]
单细胞测序结合空间转录组学揭示了瘢痕性脱发毛囊靶向炎症模式特征
Qitao Chen,Yuqian Li,Qilin Zhu et al.
Qitao Chen et al.
Background: Primary cicatricial alopecia (PCA) causes irreversible hair loss due to immune-mediated hair follicle destruction. This study investigates follicle-targeted inflammation in lichen planopilaris (LPP), a major P...
Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process [0.03%]
细胞凝聚启动器官生成：肌动蛋白动力学在超细胞自我组织过程中的作用
Jun-Xi He,Bing-Dong Sui,Yan Jin et al.
Jun-Xi He et al.
The emergence of complex tissue architectures from homogeneous stem cell condensates persists as a central enigma in developmental biology. While biochemical signaling gradients have long dominated explanations of organ patterning, the mech...
HTT loss-of-function contributes to RNA deregulation in developing Huntington's disease neurons [0.03%]
亨廷顿舞蹈病神经元发育过程中HTT失活导致RNA异常调节
Emilia Kozłowska,Agata Ciołak,Grażyna Adamek et al.
Emilia Kozłowska et al.
Background: Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats in the HTT gene, which results in a long polyglutamine tract in the huntingtin protein (HTT). One of the earlies...
The role of m6A RNA methylation in a love-hate relationship between porcine rotavirus and host cells [0.03%]
m6A RNA甲基化在猪轮状病毒与宿主细胞相爱相杀关系中的作用研究
Yaxu Liang,Xuejiao Zhu,Ruhao Zhuo et al.
Yaxu Liang et al.
N6-methyladenosine (m6A), the most abundant mRNA modification, regulates various mRNA metabolism to affect numerous physiological processes, including immune response. Interestingly, many RNA viruses contain internal m6A modifications that ...
Regulation of revival stem cell differentiation by CREPT/RPRD1B during intestinal regeneration [0.03%]
CREPT/RPRD1B在肠道再生过程中调控复苏干细胞分化的作用机制研究
Tingwei Lan,Mengdi Li,Xiaolin Duan et al.
Tingwei Lan et al.
Revival stem cells (revSCs) defined by transient induction of clusterin (CLU) expression rapidly expand and differentiate into multiple IEC lineages during intestinal regeneration. Although revSC induction is well-studied, the mechanisms go...