AFF4 promotes tumor progression and cisplatin resistance by modulating the PTEN/PI3K/AKT/mTOR axis to accelerate glycolysis in lung adenocarcinoma [0.03%]
AFF4通过调节PTEN/PI3K/AKT/mTOR轴加速糖酵解促进肺腺癌发展的顺铂耐药性
Xufeng Yao,Qian Chai,Yuhao Ma et al.
Xufeng Yao et al.
Background: Although aerobic glycolysis contributes to malignancy and drug resistance in human cancers, the vital regulators of glycolysis in lung adenocarcinoma (LUAD) remain largely unknown. Transcription factor AF4/FMR...
Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons [0.03%]
溶血磷脂酸选择性调节海马神经元的兴奋性突触传递
Nicola Brandt,Arne Battefeld,Olga Suckau et al.
Nicola Brandt et al.
Background: Lysophosphatidic acid (LPA) is a bioactive phospholipid that affects hippocampal excitatory synaptic transmission. Results: ...
Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population [0.03%]
台湾汉族人群空腹胰岛素及相关性状的多基因风险评分研究
Wei-De Lin,Wen-Ling Liao,Ting-Yuan Liu et al.
Wei-De Lin et al.
Background: Insulin regulates blood sugar levels and several physiological processes, but many aspects of the relationship between insulin regulation and genes still require further discussion. Thus, this study aimed to e...
DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases [0.03%]
贯穿一生的DNA损伤回应及细胞命运抉择：从胎儿发育到与年龄相关的呼吸系统疾病
Xuewei Cui,Ye Wang,Jianhua Fu
Xuewei Cui
The integrity and stability of DNA, an essential genetic material, need to be maintained for normal cellular function, growth, and development. The DNA damage response (DDR) constitutes a complex, sophisticated, and extensive signaling netw...
Multi-omics analysis unveiled fibroblast-mediated pathogenesis in male genital lichen sclerosus [0.03%]
多组学分析揭示了男性生殖器扁平苔藓中成纤维细胞介导的发病机制
Lede Lin,Yu Liu,Xiaocheng Wang et al.
Lede Lin et al.
Male genital lichen sclerosus (LS), a chronic inflammatory dermatological condition, has been recognized for its profound implications on the quality of life among males. The exact etiological factors behind this prevalent condition remaine...
Chen-Jun Guo,Xiaojie Bao,Ji-Long Liu
Chen-Jun Guo
CTP synthase (CTPS) is a key enzyme in de novo CTP synthesis, playing a critical role in nucleotide metabolism and cellular proliferation. Human CTPS1 (hCTPS1), one of the two CTPS isoforms, is essential for immune responses and is highly e...
Ge Cheng,Chi Tian,Waner Wang et al.
Ge Cheng et al.
SATB2 is an AT-rich DNA-binding protein with a highly restricted expression pattern, primarily found in the brain, digestive tract, bone, and immune system, making it a promising target for medical research and clinical applications. Dysreg...
Insulin-like growth factor 2 reduces Huntington's disease aggregates via AKT and NF-κB signaling in huntington's disease [0.03%]
胰岛素样生长因子2通过AKT和NF-κB信号减少亨廷顿舞蹈病患者的聚集物
Yun-Shiuan Tung,Chih-Wei Tung,Siew Chin Chan et al.
Yun-Shiuan Tung et al.
Stem cell-derived extracellular vesicles: novel therapeutics for cerebral injury following cardiac arrest and potential mechanisms [0.03%]
心脏停搏后脑损伤的间充质干细胞源性外泌体治疗及潜在机制研究
Xiaodan Zhang,Wenbin Zhang,Ziwei Chen et al.
Xiaodan Zhang et al.
Brain injury following cardiac arrest (CA) is a significant cause of mortality and poor prognosis in patients, and effective treatment strategies remain limited. Stem cell-derived extracellular vesicles (EVs), a novel cell-free therapeutic ...
Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design [0.03%]
基于双胞胎研究设计的DNA甲基化与肥胖指标相关性的遗传影响分析
Xuanming Hong,Hui Cao,Weihua Cao et al.
Xuanming Hong et al.
Background: Both obesity and DNA methylation (DNAm) are influenced by genetic factors. Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in the...