A novel self-inhaled nicotine exposure system in murine models reveals age-dependent metabolic effects of nicotine [0.03%]
一种新颖的尼古丁自我吸入暴露系统在小鼠模型中揭示了尼古丁的年龄依赖性代谢效应
Xu Xu,Hailan Liu,Meng Yu et al.
Xu Xu et al.
Background: Nicotine is known to influence metabolism and body weight, yet existing murine models of nicotine exposure often fail to replicate human smoking behaviors accurately. To address this gap, we designed a cost-ef...
PINK1 functions in mitophagy and mitochondrial homeostasis during mice oocyte maturation [0.03%]
PINK1在小鼠卵母细胞成熟过程中的自噬和线粒体稳态功能研究
Shiwei Wang,Xuan Wu,Mengmeng Zhang et al.
Shiwei Wang et al.
Background: As a serine/threonine kinase, PINK1 (PTEN-induced putative kinase 1) is widely expressed in mammalian tissues and cells, especially in the female reproductive system. However, its role in meiotic oocytes remai...
M1-BMDMs with Wnt5a deletion attenuate liver fibrosis by suppression of Wnt5a/Frizzled 2 axis in hepatic progenitors [0.03%]
通过抑制卵黄索5A/簇状蛋白2轴，M1-BMDMs中Wnt5a缺失可减轻肝纤维化
Fei-Fei Xing,Dan-Yang Wang,Yan-Nan Xu et al.
Fei-Fei Xing et al.
Background: Bone marrow-derived macrophages (BMDMs) regulate hepatic progenitor cells (HPCs) differentiation, potentially via the Wnt signaling pathway. While M1-polarized BMDMs (M1-BMDMs) exert anti-fibrotic effects in t...
Enriched environment inhibits GLT-1 ubiquitination by downregulating SMURF1 to attenuate ischemic brain injury induced excitotoxicity [0.03%]
富化环境通过下调SMURF1抑制GLT-1泛素化从而减轻缺血性脑损伤诱发的兴奋毒性
Yi Zhang,Wen Liu,Tao Huang et al.
Yi Zhang et al.
Background: Excitotoxicity induced by glutamate contributes significantly to ischemic brain injury. The role of enriched environment (EE) in promoting neurological recovery post-stroke is well-established, yet its impact ...
Biological functions and clinical implications of the CMPK2 across multisystemic diseases [0.03%]
CMPK2在多系统疾病中的生物学功能及临床意义
Jia Li,Qing Liu,Jie Yang et al.
Jia Li et al.
Cytidine/Uridine monophosphate kinase 2 (CMPK2) is a crucial enzyme responsible for the phosphorylation of nucleotides, specifically converting cytidine monophosphate (CMP) and uridine monophosphate (UMP) into their respective diphosphates,...
Meihong Shi,Guangsheng Li,Hannah Marie Araujo et al.
Meihong Shi et al.
Background: Morphologic sex differences between males and females typically emerge after the primordial germ cell migration and gonad formation, although sex is determined at fertilization based on chromosome composition....
Retraction Note: Long non-coding RNA CASC15 promotes melanoma progression by epigenetically regulating PDCD4 [0.03%]
撤回 notice: lncRNA CASC15通过表观遗传调控PDCD4促进黑色素瘤进展
Yakun Yin,Bin Zhao,Dongqin Li et al.
Yakun Yin et al.
Spinal cord ischemia reperfusion injury induces cuproptosis in neurons [0.03%]
脊髓缺血再灌注损伤通过杯状物形成诱导神经元死亡
Lei Xie,Hang Wu,Qiuping He et al.
Lei Xie et al.
Background: Spinal cord ischemia reperfusion injury (SCIRI) is a serious disease that can result in irreversible neuronal damage, leading to the loss of sensory and motor function. Cuproptosis, a novel form of regulated c...
The role of the striatin family proteins in hippo signaling and cellular regulation [0.03%]
Stripactin蛋白家族在Hippo信号传导及细胞调控中的作用
Yarden Shor-Nareznoy,Michal Caspi,Yan Lender et al.
Yarden Shor-Nareznoy et al.
The striatin family proteins, striatin, SG2NA, and zinedin, belong to the calmodulin-binding WD-40 repeat protein group and are components of the striatin interacting phosphatase and kinase (STRIPAK) complex. These proteins are known for th...
Mitochondrial echoes in the bloodstream: decoding ccf-mtDNA for the early detection and prognosis of hepatocellular carcinoma [0.03%]
揭秘外周血细胞环状线粒体DNA在肝癌早期诊断和预后价值
Yu-De Chu,Wei-Ting Chen,Wey-Ran Lin et al.
Yu-De Chu et al.
Hepatocellular carcinoma (HCC), the most common primary liver cancer, remains a major global health burden due to its high recurrence, late diagnosis, and limited prognostic tools. While imaging and treatment modalities have advanced, there...