HnRNP M expression rescues neurodegeneration in neuronal intranuclear inclusion disease mouse model by restoring dysregulated RNA splicing and transcription [0.03%]
hnRNPM表达通过恢复紊乱的RNA剪接和转录来挽救神经元内包涵体疾病的鼠模型中的神经退行性病变
Yongcheng Pan,Yangping Li,Ying Jiang et al.
Yongcheng Pan et al.
Background: Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease caused by the expanded GGC repeats in the NOTCH2NLC gene, yet its underlying pathogenic mechanisms remains to be fully elucidated. ...
Correction: The dual role of mTOR signaling in lung development and adult lung diseases [0.03%]
关于mTOR信号在肺发育和成人肺病中的双重作用的更正通知
Jiahui Bao,Wenjing Bao,Yajie Song et al.
Jiahui Bao et al.
Published Erratum
Cell & bioscience. 2025 Oct 4;15(1):133. DOI:10.1186/s13578-025-01465-z 2025
The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway [0.03%]
miR-34/449簇通过Wnt/β-catenin信号通路调控输卵管纤毛细胞分化
Qiqian Wu,Yunxia Zhang,Furong Bai et al.
Qiqian Wu et al.
Background: The oviduct (or fallopian tube) plays a functional role in the transportation of gametes and early-stage embryos, serving as a site for fertilization. Any aberrations from the normal functioning of fallopian t...
The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway [0.03%]
miR-34/449簇通过Wnt/β-catenin信号通路调节输卵管纤毛细胞分化
Qiqian Wu,Yunxia Zhang,Furong Bai et al.
Qiqian Wu et al.
Background: The oviduct (or fallopian tube) plays a functional role in the transportation of gametes and early-stage embryos, serving as a site for fertilization. Any aberrations from the normal functioning of fallopian t...
Cross-ancestry discovery of genetic risk variants for lean metabolic dysfunction-associated steatotic liver disease [0.03%]
跨谱系发现与消瘦的代谢功能障碍相关性肝脂肪变性疾病遗传风险变异
Shan-Wei Hsu,Min-Rou Lin,Wan-Hsuan Chou et al.
Shan-Wei Hsu et al.
Background: The presence of metabolic dysfunction-associated steatotic liver disease (MASLD) in lean patients challenges the traditional association between fatty liver and obesity. While genome-wide association studies (...
Cross-ancestry discovery of genetic risk variants for lean metabolic dysfunction-associated steatotic liver disease [0.03%]
跨祖先鉴定与代谢功能障碍相关脂肪肝疾病遗传风险变异位点
Shan-Wei Hsu,Min-Rou Lin,Wan-Hsuan Chou et al.
Shan-Wei Hsu et al.
Background: The presence of metabolic dysfunction-associated steatotic liver disease (MASLD) in lean patients challenges the traditional association between fatty liver and obesity. While genome-wide association studies (...
Challenges and opportunities in technologies and methods for lncRNA structure determination [0.03%]
长非编码RNA结构测定技术与方法挑战及机遇
Maximilia Frazao De Souza Degenhardt,Yun-Xing Wang
Maximilia Frazao De Souza Degenhardt
Long non-coding RNAs (lncRNAs) play pivotal roles in diverse cellular processes ranging from gene regulation and chromatin remodeling to RNA stability and epigenetic modifications. Despite the identification of approximately 95,000 lncRNA g...
Challenges and opportunities in technologies and methods for lncRNA structure determination [0.03%]
长非编码RNA结构鉴定的技术与方法挑战及机遇
Maximilia Frazao De Souza Degenhardt,Yun-Xing Wang
Maximilia Frazao De Souza Degenhardt
Long non-coding RNAs (lncRNAs) play pivotal roles in diverse cellular processes ranging from gene regulation and chromatin remodeling to RNA stability and epigenetic modifications. Despite the identification of approximately 95,000 lncRNA g...
Single-cell transcriptomics of organoids reveals transcriptional control of germline stem cell fate by an E2F1-TFAP2C-SOX17 positive-feedback loop in Turner syndrome [0.03%]
单细胞转录组揭示E2F1-TFAP2C-SOX17正反馈回路在特纳综合征中调控生殖系干细胞命运
Dantong Shang,Yue Wang,Tian Lan et al.
Dantong Shang et al.
Background: Turner syndrome is the most common sex chromosome abnormality in females and affects approximately 1-2 in 2500 girls and women. To date, no cure is available for the treatment of infertility in Turner syndrome...
KDM4A-driven SMAD5/TGFβ axis activation as a therapeutic target in cholangiocarcinoma: mechanistic insights and translational implications [0.03%]
KDM4A驱动的SMAD5/TGFβ轴活化作为肝内胆管癌治疗靶点：机制见解和转化意义
Qi Wang,Yiyang Kuai,Fei Xiong et al.
Qi Wang et al.
Background: Cholangiocarcinoma is a malignancy with poor prognosis and increasing incidence in recent years. Apart from early surgical resection, other treatments have shown limited efficacy. Lysine-specific demethylase 4...