Trim7 aggravates ischemic stroke-associated ferroptosis by promoting ubiquitin-mediated degradation of HSPA5 [0.03%]
TRIM7通过促进Ubiquitin介导的HSPA5降解加重缺血性脑卒中相关的铁死亡
Wenxuan Lu,Sha Hu,Wenhui Zhang et al.
Wenxuan Lu et al.
Objective: Ischemic stroke is a leading cause of neurological disability and death worldwide, posing a substantial threat to human health. Tripartite motif-containing protein 7 (Trim7), an E3 ubiquitin ligase, is involved...
LARP1 acts as a key mediator in preventing angiotensin II-induced cardiac dysfunction and fibrosis [0.03%]
LARP1充当关键调解因子以防止血管紧张素II引起的心脏功能障碍和纤维化
Haikuo Zheng,Chuang Yang
Haikuo Zheng
Background: Cardiac remodeling underlies many cardiovascular diseases and is characterized by cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis, leading to structural and functional deterioration of the hear...
Ssrp governs germline development independent of the FACT complex in Drosophila spermatogenesis [0.03%]
SSRP蛋白在果蝇精发生过程中独立于FACT复合物调控生殖细胞发育
Xiaoning Tan,Yuhan Lou,Zhiyong Yin et al.
Xiaoning Tan et al.
Background: The heterodimeric FACT complex (SSRP1/Ssrp and SUPT16H/Dre4) is primarily recognized as a chromatin remodeler. While mutations in this complex are linked to human intellectual disability and it maintains neura...
CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla [0.03%]
圆盘状DNA片段Cdh7诱导星形胶质细胞增生和神经炎症从而触发延髓头端腹外侧区的高血压效应
Shuai Zhang,Tengteng Dai,Bingjie Zhao et al.
Shuai Zhang et al.
Background: The rostral ventrolateral medulla (RVLM) is a critical vasomotor center that plays a pivotal role in the pathogenesis of hypertension. However, the involvement of circular RNAs (circRNAs) in this nucleus in bl...
Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [0.03%]
血管生成素样蛋白8通过JNK信号通路调节细胞因子风暴综合征中的巨噬细胞糖原代谢和极化
Yang Su,Rongtian Zhang,Kongdong Li et al.
Yang Su et al.
Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting ...
USP43 promotes cerebral ischemia-reperfusion injury via activation of TAK1 [0.03%]
USP43通过激活TAK1促进脑缺血再灌注损伤
Yuhan Dong,Sha Hu,Rui Zhang et al.
Yuhan Dong et al.
Background: Neuroinflammation and apoptosis are important processes of cerebral ischemia-reperfusion injury. USP43 has been shown to play an important role in a variety of cancers, but its function in the field of neurosc...
Zinc finger protein Zfp335 is required for T cell homeostatic proliferation through regulating Lmnb1 [0.03%]
锌指蛋白Zfp335通过调节Lmnb1调控T细胞稳态增殖
Biao Yang,Wenhua Li,Xin Wang et al.
Biao Yang et al.
Background: T cell homeostasis is crucial for maintaining T cell population size and upcoming protective immunity in the peripheral organs. However, it remains largely unknown about the intracellular molecules and pathway...
Roles of glucagon-like peptide 1 receptor agonists in immune cell biology and autoimmune/autoinflammatory diseases [0.03%]
肠降糖肽1受体激动剂在免疫细胞生物学和自身免疫/炎症疾病中的作用
Sihui Deng,Zeyu Chen,Yuling Shi
Sihui Deng
Glucagon-like peptide-1 (GLP-1) is a gut-derived hormone essential for maintaining glucose homeostasis through multiple physiological pathways: triggering insulin release, inhibiting glucagon secretion, delaying gastric emptying, enhancing ...
Correction: CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury [0.03%]
correction：Circrna Itm2b通过与Sirt1-Nox4的相互作用诱导氧化应激以加重创伤性脑损伤后的睡眠障碍
Jiayuanyuan Fu,Mengran Du,Biying Wu et al.
Jiayuanyuan Fu et al.
Published Erratum
Cell & bioscience. 2025 Oct 9;15(1):136. DOI:10.1186/s13578-025-01413-x 2025
The complex interplay between diabetes mellitus and pancreatic carcinogenesis: deciphering multifactorial mechanisms and identifying emerging therapeutic vulnerabilities [0.03%]
糖尿病与胰腺癌发生发展的相互作用及治疗新靶点研究进展
Cui-Ni Lu,Ji-Bin Liu,Zi-Yu Chen et al.
Cui-Ni Lu et al.
Diabetes mellitus (DM) represents a significant global public health challenge, as economic development and changes in modern dietary habits have contributed to a rising prevalence of DM patients. Pancreatic cancer (PC), a highly aggressive...