The multifaceted roles of non-coding RNAs in cell-cell communication in cardiovascular health and disease [0.03%]
非编码RNA在心血管健康和疾病中细胞间通讯的多种作用
Danica Jimenez-Gallegos,Francisco Sigcho,Emiliano Vicencio et al.
Danica Jimenez-Gallegos et al.
Non-coding RNAs are critical regulators of cell-to-cell communication in the cardiovascular system, playing pivotal roles in heart development, function, and disease progression. Among these, extracellular vesicles, RNA-binding proteins, an...
SETD7 exacerbates diabetic nephropathy through activating A2B receptor-JAK2/STAT3 pathway [0.03%]
组蛋白甲基转移酶SETD7通过激活A2B受体/JAK2-STAT3信号通路加重糖尿病肾病
Qiuyuan Huang,Wen Zhong,Ruoxue Chen et al.
Qiuyuan Huang et al.
Objective: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), and there has been growing attention towards the role of epigenetics in its pathogenesis. This study aims to investigate the under...
PA2G4 in CAFs promotes biochemical recurrence of prostate cancer via H3K18la [0.03%]
PA2G4在CAF中通过H3K18la促进前列腺癌生化复发
Shiyu Ji,Zhen Xi,Tiewen Li et al.
Shiyu Ji et al.
Cancer-associated fibroblasts (CAFs) exhibit heterogeneity and play diverse roles in prostate cancer (PCa) progression, yet their specific impact via lactate metabolism remains unexplored. This study identifies a CAFs lactate metabolism-ass...
FAK-dependent activation of src family kinase member BLK contributed to endometrial fibrosis via endoplasmic reticulum stress [0.03%]
依赖FAK的Src家族激酶成员BLK的活化通过内质网应激促进子宫内膜纤维化
Yimeng Lu,Xudong Zhang,Shanshan Wu et al.
Yimeng Lu et al.
Background: While Src family kinases (SFKs) are established mediators of some fibrotic diseases, their specific function in endometrial fibrosis is not well defined. Here, we investigated the function and underlying mecha...
Inhibition of miR-4284 could reduce apoptosis and neuroinflammation by targeting APBA1/JAK1/STAT3 signaling in Alzheimer's disease [0.03%]
抑制miR-4284通过靶向APBA1/JAK1/STAT3信号通路减少阿尔茨海默病中的凋亡和神经炎症作用
Jiyun Choi,Jinsu Hwang,Dohee Kim et al.
Jiyun Choi et al.
Background: microRNA-4284 is associated with various diseases, but its role in Alzheimer's disease remains unclear. This study explores the therapeutic potential of miR-4284 inhibition by targeting the APBA1 and the JAK/S...
BAP18, as a corepressor of AR together with the SIN3A/HDAC complex, promotes AR-positive triple-negative breast cancer progression [0.03%]
BAP18与SIN3A/HDAC复合体一起作为AR的核心抑制剂，促进阳性三阴性乳腺癌的进展
Yiqi Zhang,Zining Jin,Yi Wu et al.
Yiqi Zhang et al.
Background: Triple-negative breast cancer (TNBC) is considered a highly heterogeneous disease. Androgen receptor (AR)-positive TNBC is a subtype with distinct molecular features. However, the molecular mechanism underlyin...
Sexual dimorphism in colon is mediated by an androgen-IL33+ stromal cell axis [0.03%]
雄激素-IL33+间质细胞轴介导结肠的性别二态性
Haoyu Wang,Baowei Jing,Juan Zou et al.
Haoyu Wang et al.
Background: Males and females exhibit pronounced disparity in the epidemiology, clinical progression, and therapeutic outcomes of colonic diseases, but the underlying mechanisms that regulate sexual dimorphism of colon re...
IgD in nucleus of pro-B cells promotes pro-B cells proliferation by regulating E2F3 expression [0.03%]
IgD通过调节E2F3的表达促进pro-B细胞增殖及其在细胞核中的定位研究
Yixiao Zhang,Yanqi Hou,Meng Yu et al.
Yixiao Zhang et al.
Background: Immunoglobulin D (IgD) has historically been considered as a surface marker of mature B cell with its specific function being undefined. Until now, no evidence had been presented to suggest that IgD is also ex...
Yixin Fan,Xiaomin Wang,Ziwei Zhai et al.
Yixin Fan et al.
Background: In stem cell biology, a long-held structure-function relationship is the domed colony morphology and naïve pluripotency for mouse or human pluripotent stem cells. This link has provided a convenient way to re...
sRAGE inhibits myocardial ischemia/reperfusion injuries via regulating Treg cells [0.03%]
sRAGE通过调节Treg细胞抑制心肌缺血/再灌注损伤
Jian Liu,Jie Zhang,Jing Chang et al.
Jian Liu et al.
Background: Regulatory T cells (Tregs) have been documented to accumulate in damaged myocardial tissue, where they play a pivotal role in attenuating excessive inflammatory responses during myocardial ischemia/reperfusion...