TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice [0.03%]
TRIM16介导YAP1的K63链状泛素化通过YAP/Nrf2轴缓解小鼠脓毒症诱导的急性肝损伤
Kaina Zhang,Mengqing Liu,Yeqing Zheng et al.
Kaina Zhang et al.
Sepsis-induced liver injury is associated with high morbidity and mortality, yet its underlying mechanisms remain elucidated. In this study, we observed a significant reduction in the E3 ubiquitin ligase TRIM16 in lipopolysaccharide (LPS)-i...
Shi-Jia Huang,Hui-Lin Ye,Shuo Xu et al.
Shi-Jia Huang et al.
The incidence of inflammatory bowel disease (IBD) has been increasing, and while the interaction between T cells and intestinal microorganisms is crucial in its pathogenesis, the related epigenetic mechanisms remain unclear. This study foun...
Ketogenic diets and metabolic dysfunction-associated steatotic liver disease: a literature review [0.03%]
生酮饮食与代谢性失常脂肪肝病：文献综述
Kexin Sun,Weitian Li,Yunan Chen et al.
Kexin Sun et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect over 30% of the global population with a rising trend, posing significant healthcare burden due to its progression and increased risk of related metabol...
A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow [0.03%]
KLF2调控的线粒体氧化磷酸化在维持骨髓来源的间充质干细胞干性中的关键作用
Zhiyuan Gong,Yangxi Cheng,Rui Deng et al.
Zhiyuan Gong et al.
Mesenchymal stem cells (MSCs) have many uses in tissue engineering and clinical applications. However, maintaining their stemness during in vitro expansion is challenging. We previously found that Krüppel-like factor 2 (KLF2) plays a cruci...
Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates [0.03%]
细胞内原蛋白和钙离子触发α-突触核蛋白聚集体的神经毒性
Alessandra Bigi,Andrea Carlotta Conti,Liliana Napolitano et al.
Alessandra Bigi et al.
Background: The aggregation of α-Synuclein (αS) into amyloid fibrils and their deposition in intraneuronal Lewy bodies are hallmark features of Parkinson's disease (PD) and other synucleinopathies. Among the molecular p...
A CCL5+CD20+CD8+ T cell subset drives pathogenic transformation of synoviocytes in rheumatoid arthritis via JAK-STAT signaling [0.03%]
携带CCL5+CD20+CD8+受体的T细胞亚群通过JAK-STAT信号转导驱动类风湿性关节炎中滑膜纤维母细胞向病理状态转化
Haonan Jia,Jiawei Xue,Suna Jiang et al.
Haonan Jia et al.
Old dogs-new tricks: multifaceted functions of MAVS beyond antivirus activity in human health and diseases [0.03%]
老狗新把戏：人类健康与疾病中 MAVS 的多重功能超越抗病毒作用
Yating Lu,Yaxuan Qi,Qingqing Yinliang et al.
Yating Lu et al.
Mitochondrial Antiviral Signaling Protein (MAVS), a key adaptor in the innate immune system, has traditionally been recognized for its role in defending against viral infections through activation of the interferon (IFN) and NF-κB signalin...
The function of NAT10-driven N4-acetylcytidine modification in cancer: novel insights and potential therapeutic targets [0.03%]
NAT10驱动的N4-乙酰胞苷修饰在癌症中的功能：新见解与潜在治疗靶点
Yi Wang,Sheng Wang,Maoyun Liu et al.
Yi Wang et al.
N4-acetylcytidine (ac4C) is a novel RNA modification that plays important biological roles in a variety of diseases, including tumors, by regulating gene expression at the posttranscriptional level. As a currently known ac4C-modified "writi...
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease [0.03%]
RNF186通过调节糖异生抑制代谢功能紊乱相关性脂肪肝病的发展
Jiang Du,Qizhang Du,Yuxuan Zhang et al.
Jiang Du et al.
Background and aims: RNF186, which encodes a ring-finger domain-containing E3 ubiquitin-protein ligase, has previously been implicated in the regulation of lipid metabolic disorders associated with metabolic dysfunction-r...
Attenuated innate immunity in embryonic stem cells: mechanisms and therapeutic applications [0.03%]
胚胎干细胞的弱化先天免疫：机制与治疗应用
Sheng Chen,Ruonan Wang,Jingyuan Yang et al.
Sheng Chen et al.