Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m6A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response [0.03%]
锌指蛋白ZNF33B通过调节Ifih1和Irf3转录本上的m6A修饰来促进日本脑炎病毒的复制以对抗抗病毒反应
Jian Du,Chunwei Li,Jinyan Zhang et al.
Jian Du et al.
Japanese encephalitis virus (JEV), a neurotropic flavivirus, poses a significant public health threat, yet the molecular mechanisms underlying its interaction with host immunity remain poorly understood. This study reveals that zinc finger ...
Fusion oncoproteins orchestrate tumorigenesis and sustain malignant progression via a positive feedback mechanism [0.03%]
融合癌蛋白通过正反馈机制协调肿瘤发生并维持恶性进展
Wenwen Ying,Xiaomin Wang,Jiayi Yu et al.
Wenwen Ying et al.
Chromosomal translocations are prevalent genetic events across multiple pediatric cancers, notably in CNS tumors, solid tumors, and leukemias. For decades, Fusion oncoproteins resulting from chromosomal translocations have been proposed as ...
Anti-seizure potential of J4, an equilibrative nucleoside transporter 1 inhibitor, in a mouse model of tuberous sclerosis complex in response to pentylenetetrazol [0.03%]
J4(平衡核苷转运蛋白1抑制剂)在戊四唑反应性结节性硬化小鼠模型中的抗癫痫潜能研究
Christine Chin-Jung Hsieh,Nai-Kuei Huang,Szu-Yu Tung et al.
Christine Chin-Jung Hsieh et al.
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder with epileptic seizures caused by genetic mutations in either TSC1 or TSC2 gene. Multiple genetic, epigenetic, and environmental factors can affect the phenotypical outcomes ...
Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells [0.03%]
肝纤维化/肝硬化细胞治疗的机制、疗效及未来前景：侧重于间充质基质细胞
Xuan Pan,Tianyun Gao,Bin Wang
Xuan Pan
Liver fibrosis/cirrhosis, characterized by excessive deposition of extracellular matrix (ECM) and formation of fibrous scars, arises from chronic liver injury and poses a significant global health burden. Although liver transplantation rema...
Recombinant attenuated Salmonella vaccine promotes CD8+ T cell-dependent antitumor immunity via IFN-γ-induced IRF-1-mediated upregulation of IL-7 [0.03%]
干扰素-γ诱导的IRF-1介导的白细胞介素-7上调促进重组减毒沙门氏菌疫苗诱发CD8+T细胞依赖性抗肿瘤免疫作用
Jae-Hyeon Jeong,Dae-Joon Kim,Chae-Won Kim et al.
Jae-Hyeon Jeong et al.
Background: Cancer is a leading cause of mortality worldwide, necessitating the development of novel therapeutic targets and strategies to prevent recurrence and metastasis. In this study, we aimed to evaluate whether a r...
ZMIZ2 interacts with PIN1 to promote lung adenocarcinoma EMT and metastasis via activation of the PI3K/AKT pathway [0.03%]
ZMIZ2通过激活PI3K/AKT信号通路与PIN1相互作用促进肺腺癌EMT和转移
Zhiyue Su,Yuhong Wang,Ersuo Jin et al.
Zhiyue Su et al.
ZMIZ2, a transcription co-activator, is frequently overexpressed in various tumors. However, its functional role and molecular mechanisms in driving non-small cell lung cancer (NSCLC) metastasis remain elusive. Our study reveals that ZMIZ2 ...
PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues [0.03%]
PGC-1α：代谢和再生组织中线粒体生物发生和细胞分化的关键调节因子
Lijuan Cao,Yanan Li,Artem Smirnov et al.
Lijuan Cao et al.
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a crucial coactivator that regulates mitochondrial biogenesis and function across diverse tissues, including the brain, heart, skeletal muscle, bone marrow, and live...
Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4 [0.03%]
米非司酮通过上调PDCD4抑制黄体酮受体，从而抑制胎盘干细胞并促进细胞凋亡
Jie Zhou,Li Yan,Yamei Li et al.
Jie Zhou et al.
Background: Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast reg...
Pluripotent stem cells-based neural organoids for modelling human brain development and diseases [0.03%]
基于多能干细胞的类脑器官模拟人类大脑发育和疾病研究
Lingling Tong,Peiqi Tian,Ruoxi Wang et al.
Lingling Tong et al.
Brain organoids have emerged as transformative in vitro models for studying human neurodevelopment, neural disorders, and evolutionary brain complexity. This review systematically compares neural development in mice and humans, reflecting t...
PRSS55 regulates BCAA metabolism and interacts with BCKDK and BCKDHA in mouse testes and sperm [0.03%]
PRSS55调节支链氨基酸代谢并相互作用于鼠睾丸和精子中的BCKDK和BCKDHA
Haoyang Ge,Chunling Shen,Wenfeng Xiong et al.
Haoyang Ge et al.
Backgrounds: Recent research has emphasized the significance of testis-specific serine proteases in regulating various aspects of sperm maturation and function. Among them, serine protease 55 (PRS55) plays an important ro...