CD44 fucosylation on bone marrow-derived mesenchymal stem cells enhances homing and promotes enteric nervous system remodeling in diabetic mice [0.03%]
骨髓间充质干细胞CD44岩藻糖基化增强归巢并促进糖尿病小鼠肠神经系统重塑
Huiying Shi,Chen Jiang,Hailing Yao et al.
Huiying Shi et al.
Background: Diabetes can cause extensive enteric nervous system (ENS) injuries and gastrointestinal motility disorder. In developing possible treatments, researchers have engaged in tissue regeneration engineering with th...
ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12 [0.03%]
PARP11与PARP12协同抑制寨卡病毒
Lili Li,Yueyue Shi,Sirui Li et al.
Lili Li et al.
Background: Zika virus (ZIKV) infection and ZIKV epidemic have been continuously spreading silently throughout the world and its associated microcephaly and other serious congenital neurological complications poses a sign...
Mei Zhang,Hong-Chun Xian,Li Dai et al.
Mei Zhang et al.
The perineural invasion (PNI), which refers to tumor cells encroaching on nerve, is a clinical feature frequently occurred in various malignant tumors, and responsible for postoperative recurrence, metastasis and decreased survival. The pat...
Weina Zhong,Dathe Z Benissan-Messan,Jianjie Ma et al.
Weina Zhong et al.
Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a T...
Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion [0.03%]
SARS-CoV-2刺突蛋白ER滞留信号的缺失可减少细胞融合过程中的细胞杂交现象
Xuening Wang,Chih-Hsiung Chen,Saiaditya Badeti et al.
Xuening Wang et al.
Background: The novel SARS-CoV-2 has quickly become a global pandemic since the first reported case in December 2019, with the virus infecting millions of people to date. The spike (S) protein of the SARS-CoV-2 virus play...
Protein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine [0.03%]
蛋白精氨酸甲基转移酶1调节小鼠成体肠的细胞增殖和分化
Lu Xue,Lingyu Bao,Julia Roediger et al.
Lu Xue et al.
Background: Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of t...
Aging and respiratory viral infection: from acute morbidity to chronic sequelae [0.03%]
衰老与呼吸道病毒感染：从急性期到慢性期
Yue Wu,Nick P Goplen,Jie Sun
Yue Wu
The altered immune response in aged hosts play a vital role in contributing to their increased morbidity and mortality during respiratory virus infections. The aged hosts display impaired antiviral immune response as well as increased risk ...
Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium [0.03%]
电信号平衡后部和前部PTEN信号引导Dictyostelium迁移
Bing Song,Yu Gu,Wenkai Jiang et al.
Bing Song et al.
Background: Cells show directed migration response to electric signals, namely electrotaxis or galvanotaxis. PI3K and PTEN jointly play counterbalancing roles in this event via a bilateral regulation of PIP3 signaling. PI...
Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2 [0.03%]
果蝇——研究病毒与宿主相互作用及病原性以对抗SARS-CoV-2的有力模型
Joyce van de Leemput,Zhe Han
Joyce van de Leemput
The COVID-19 pandemic is having a tremendous impact on humanity. Although COVID-19 vaccines are showing promising results, they are not 100% effective and resistant mutant SARS-CoV-2 strains are on the rise. To successfully fight against SA...
Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: "alliance" or "war" in intercellular signals [0.03%]
间充质（干细胞）在癌症生物学中的起源的重要性：“细胞信号”是“联盟”还是“战争”？
Noemi Eiro,Maria Fraile,Silvia Fernández-Francos et al.
Noemi Eiro et al.
Mesenchymal stem cells (MSCs) play a central role in the intercellular signaling within the tumor microenvironment (TME), exchanging signals with cancer cells and tumor stromal cells, such as cancer-associated fibroblasts and inflammatory m...