CpG oligodeoxynucleotides attenuate RORγt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma [0.03%]
CpG寡脱氧核糖核酸通过恢复哮喘小鼠气道上皮细胞HDAC2的表达抑制RORγt介导的Th17应答
Hongtao Li,Qimei Ye,Yusen Lin et al.
Hongtao Li et al.
Background: Cigarette smoke (CS) exposure increases corticosteroid insensitive asthma related to increased Th17 phenotype, and new treatment strategies are needed for CS-associated asthma. Histone deacetylase 2 (HDAC2), f...
The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation [0.03%]
运动对骨髓间充质干细胞命运的影响：机械调控和骨形成的启示
Yuanxiu Sun,Yu Yuan,Wei Wu et al.
Yuanxiu Sun et al.
Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and can differentiate into chondrocytes, osteoblasts, and adi...
Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell-cell contact to activate the Jagged1/Notch1 pathway [0.03%]
骨髓间充质干细胞通过细胞接触激活Jagged1/Notch1信号促进前列腺癌干细胞属性_traits
Ji-Wen Cheng,Li-Xia Duan,Yang Yu et al.
Ji-Wen Cheng et al.
Background: Mesenchymal stem cells (MSCs) play a crucial role in cancer development and tumor resistance to therapy in prostate cancer, but the influence of MSCs on the stemness potential of PCa cells by cell-cell contact...
The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives [0.03%]
慢性肾脏病的肾微循环：新颖诊断方法和治疗视角
Shulin Li,Fei Wang,Dong Sun
Shulin Li
Chronic kidney disease (CKD) affects 8-16% of the population worldwide and is characterized by fibrotic processes. Understanding the cellular and molecular mechanisms underpinning renal fibrosis is critical to the development of new therape...
Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans [0.03%]
放疗诱导的变异链球菌gtfB基因同义点突变降低了菌群形成能力和致龋力
Zheng Wang,Yujie Zhou,Qi Han et al.
Zheng Wang et al.
Background: The shift of oral microbiota is a critical factor of radiation caries in head and neck cancer patients after the radiotherapy. However, the direct effects of irradiation on the genome and virulence of cariogen...
Neurohormonal activation induces intracellular iron deficiency and mitochondrial dysfunction in cardiac cells [0.03%]
神经激素激活会诱导心脏细胞发生胞内铁缺乏和线粒体功能障碍
M Tajes,C Díez-López,C Enjuanes et al.
M Tajes et al.
Background: Iron deficiency (ID) is common in patients with heart failure (HF) and is associated with poor outcomes, yet its role in the pathophysiology of HF is not well-defined. We sought to determine the consequences o...
Urine-derived induced pluripotent/neural stem cells for modeling neurological diseases [0.03%]
尿源性诱导多能/神经干细胞在神经系统疾病模型中的应用
Tianyuan Shi,Martin Cheung
Tianyuan Shi
Neurological diseases are mainly modeled using rodents through gene editing, surgery or injury approaches. However, differences between humans and rodents in terms of genetics, neural development, and physiology pose limitations on studying...
Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review [0.03%]
YY1转录因子对胰腺内分泌和外分泌肿瘤发生发展的影响：述评
Qun Chen,Wu-Jun Wang,Yun-Xuan Jia et al.
Qun Chen et al.
Pancreatic tumors are classified into endocrine and exocrine types, and the clinical manifestations in patients are nonspecific. Most patients, especially those with pancreatic ductal adenocarcinoma (PDAC), have lost the opportunity to rece...
The YAP/HIF-1α/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation [0.03%]
YAP/HIF-1α/miR-182/EGR2轴通过调控Th17细胞分化参与哮喘病情Severity的形成
Jing Zhou,Ning Zhang,Wei Zhang et al.
Jing Zhou et al.
Background: Asthma is a heterogeneous chronic inflammatory disease of the airway, involving reversible airflow limitation and airway remodeling. T helper 17 (Th17) cells play an important role in the pathogenesis of aller...
Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes [0.03%]
slit diaphragm的维护需要AP-2、Lap、Aux和Hsc70-4介导的动态网格蛋白依赖性胞吞作用
Luyao Wang,Pei Wen,Joyce van de Leemput et al.
Luyao Wang et al.
Background: The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the i...