Old dogs-new tricks: multifaceted functions of MAVS beyond antivirus activity in human health and diseases [0.03%]
老狗新把戏：人类健康与疾病中 MAVS 的多重功能超越抗病毒作用
Yating Lu,Yaxuan Qi,Qingqing Yinliang et al.
Yating Lu et al.
Mitochondrial Antiviral Signaling Protein (MAVS), a key adaptor in the innate immune system, has traditionally been recognized for its role in defending against viral infections through activation of the interferon (IFN) and NF-κB signalin...
The function of NAT10-driven N4-acetylcytidine modification in cancer: novel insights and potential therapeutic targets [0.03%]
NAT10驱动的N4-乙酰胞苷修饰在癌症中的功能：新见解与潜在治疗靶点
Yi Wang,Sheng Wang,Maoyun Liu et al.
Yi Wang et al.
N4-acetylcytidine (ac4C) is a novel RNA modification that plays important biological roles in a variety of diseases, including tumors, by regulating gene expression at the posttranscriptional level. As a currently known ac4C-modified "writi...
RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease [0.03%]
RNF186通过调节糖异生抑制代谢功能紊乱相关性脂肪肝病的发展
Jiang Du,Qizhang Du,Yuxuan Zhang et al.
Jiang Du et al.
Background and aims: RNF186, which encodes a ring-finger domain-containing E3 ubiquitin-protein ligase, has previously been implicated in the regulation of lipid metabolic disorders associated with metabolic dysfunction-r...
Attenuated innate immunity in embryonic stem cells: mechanisms and therapeutic applications [0.03%]
胚胎干细胞的弱化先天免疫：机制与治疗应用
Sheng Chen,Ruonan Wang,Jingyuan Yang et al.
Sheng Chen et al.
Bo Li,Yu-Ying He,Zeng-Ming Yang
Bo Li
Primary cilia are solitary, non-motile, microtubule-based organelles that protrude from the surface of most vertebrate cells, functioning as highly specialized sensory and signaling compartments. Architecturally, they comprise the basal bod...
Deciphering the epigenomic regulatory variations reveals function diversity in adipose lineage among different adipose depots of pigs [0.03%]
解析表观基因组调控变异可揭示猪不同脂肪组织谱系的功能多样性
Daoyuan Wang,Renzhuo Kuang,Mingyang Hu et al.
Daoyuan Wang et al.
The distribution of adipose depots in different body parts affects pig production value and human health, governed by complex epigenomic mechanisms. Limited studies on pig adipose depots have hindered the genetic improvement of fat-related ...
KDM6B inhibition enhances chemotherapeutic response in small cell lung cancer via epigenetic regulation of apoptosis and ferroptosis [0.03%]
表观遗传调控凋亡和铁死亡KDM6B抑制增强小细胞肺癌的化疗反应
Zhongliang Wang,Ziyuan Liu,Yufan Yang et al.
Zhongliang Wang et al.
Background: Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid progression and the frequent emergence of resistance to standard chemotherapeutic agents such as cisplatin (DDP) and etopo...
PRMT1 drives oral squamous cell carcinoma progression by activating STAT3 and suppressing ferroptosis via GPX4 [0.03%]
脯氨酰-tRNA合成酶(PRMT1)通过激活STAT3和抑制GPX4介导的铁死亡驱动口腔鳞状细胞癌进展
Huawei Liu,Chuyan Shi,Bing Liu et al.
Huawei Liu et al.
Background: Oral squamous cell carcinoma (OSCC) exhibits poor prognosis due to aggression, metastasis, and chemoresistance. Protein Arginine Methyltransferase 1 (PRMT1) and Signal Transducer and Activator of Transcription...
Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage [0.03%]
出生后早期增加肺血流量可致肺泡发育异常
He Zhang,Sixie Zheng,Zheng Wang et al.
He Zhang et al.
Background: Increased pulmonary blood flow (IncPBF), one of the most important features of many children with congenital heart diseases, is well-known as a prerequisite for the induction of pulmonary arterial hypertension...
RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression [0.03%]
RNA结合蛋白PTBP1通过调节硫酸肝素皮酰氧基硫酸转移酶基因表达介导HSV-1黏附和感染
Weikang Sun,Mengyu Zhang,Ruilin Wang et al.
Weikang Sun et al.
Background: The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1), also known as heterogeneous nuclear ribonucleoprotein I (hnRNP I), mediates gene expression through splicing regulation. Its role in viru...