Inflammation-induced impairment of synaptic plasticity accelerates atherosclerosis co-depression disease: insights from bioinformatics analysis and transcriptomics [0.03%]
炎症诱发的突触可塑性损伤加速动脉粥样硬化共抑郁疾病的发生：来自生物信息学分析和转录组学的启示
Yulong Zhao,Qiang Luo,Peng Ren et al.
Yulong Zhao et al.
Background: Atherosclerosis (AS) serves as the pathological foundation for numerous cardiovascular and cerebrovascular diseases and is highly comorbid with depression. The mechanisms underlying this co-morbidity are excep...
DNA methylation-mediated silencing of MEOX1 promotes glycolysis and immune evasion in colorectal cancer cells through inhibition of GLP2R transcription [0.03%]
DNA甲基化介导的MEOX1基因沉默通过抑制GLP2R转录促进结直肠癌细胞糖酵解及免疫逃逸
Dingkong Liang,Fen Xue,Jinkun Xie et al.
Dingkong Liang et al.
Background: GLP2R has been identified as a downregulated gene in colorectal cancer (CRC) and is correlated with immunocyte infiltration. Herein, we aimed to define the molecular characteristics of GLP2R in CRC, focusing o...
In vitro mimicking of humanized cardiogenesis under porcine condition [0.03%]
体外模拟猪条件下的类人诱导多能干细胞心脏分化过程
Jiajun Li,Changjiang Xu,Bingbo Shi et al.
Jiajun Li et al.
Background: One promising strategy to generate humanized organs is through embryo complementation by injecting human pluripotent stem cells (PSCs) into gene-edited porcine embryos. This strategy is predicated on how human...
Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila [0.03%]
家蚕钙调神经磷酸酶通过prospero磷酸化维持神经干细胞的自我更新
Shuliu Zhang,Sifan Gong,Yiming Yang et al.
Shuliu Zhang et al.
Most neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis. However, the regulation of the NSC maintenance d...
Retraction Note: Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma [0.03%]
撤回 notice:胶质母细胞瘤干细胞（GSC）衍生的含 pd-l1 的外泌体激活 ampk/ulk1 通路介导的自噬以增加胶质母细胞瘤的替莫唑胺耐药性
Yong Zheng,Liang Liu,Yan Wang et al.
Yong Zheng et al.
The mutual regulation of SOX12 and RNF168 modulates cisplatin resistance in esophageal squamous cell carcinoma cells by regulating DNA damage repair [0.03%]
SOX12和RNF168的互调调节通过调节DNA修复调控食管鳞癌细胞顺铂耐药性
Ning Wang,Lun Yang,Yunhe Huang et al.
Ning Wang et al.
Background: Resistance to chemotherapy drugs is one of the significant factors for limited treatment options and poor prognosis in esophageal cancer. A study has found that SOX12 plays a role in cisplatin resistance in he...
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice [0.03%]
GLP-1受体激动剂与Akkermansia muciniphila Akk11联合应用可减轻小鼠肥胖并改善T2D小鼠MASLD病理生理学症状
Kaige Gao,Zaifei Yin,Chi Zhang et al.
Kaige Gao et al.
Aims/hypothesis: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease globally and is closely associated with type 2 diabetes (T2D) and obesity. Glucagon-like peptid...
Maternal hyperhomocysteinemia induces fetal growth restriction by suppressing angiogenesis at the maternal-fetal interface [0.03%]
高同型半胱氨酸血症通过抑制母胎界面上的血管生成诱导胎儿生长受限
Sujuan Li,Yichi Wu,Yuan Gao et al.
Sujuan Li et al.
Maternal hyperhomocysteinemia (HHcy) is closely linked to fetal growth restriction (FGR), yet the underlying mechanisms remain incompletely understood. In this study, we established a rat model of HHcy by administering a high-methionine die...
IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis [0.03%]
实验性银屑病和特应性皮炎中的皮肤炎症介导_IL-27信号通路
Zeyu Chen,Lian Cui,Zhiyi Lan et al.
Zeyu Chen et al.
Background: Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses. However, recent evidence suggests that these diseases may share ove...
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma [0.03%]
TGF-β1/SMAD信号通过直接转录抑制和FAT10介导的蛋白酶体降解下调肝癌中KLF4表达
Zeping Chen,Senlin Zhao,Desheng Chen et al.
Zeping Chen et al.
Background: Loss of tumor suppressor Krüpple-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC) is crucial for aggressive tumor progression and poor patient prognosis. However, the mechanisms underlying KL...