Healthcare resource savings from administering paliperidone palmitate once every 3 months instead of once every month for schizophrenia: a 12-month mirror-image analysis of real-world population-based data [0.03%]
关于精神分裂症患者每季度一次相比每月一次注射帕利培酮酯的医疗资源节约：一项基于真实世界人群数据的镜像分析
Ke-Fei Wu,Ya-Hui Yang,Chuan-Sheng Hung et al.
Ke-Fei Wu et al.
Background: Inadequate adherence to antipsychotic medication remains a major driver of relapse, hospitalization, and chronic disease progression in schizophrenia. Long-acting injectable (LAI) antipsychotics may reduce hea...
Levels of aripiprazole in the blood with an injection of aripiprazole administered once every two months: a plain language summary of publication [0.03%]
两个月一次的阿立哌唑注射后血液中的阿立哌唑水平：发表内容的通俗版本
Yanlin Wang,Matthew Harlin,Frank Larsen et al.
Yanlin Wang et al.
What is this summary about? The information summarized here relates to aripiprazole, a medicine that is used to treat conditions such as schizophrenia and bipolar I disorder. Researchers wanted to understand what levels of aripiprazole in t...
Anhedonia nonresponse to short-term ketamine administration for treatment-resistant bipolar depression [0.03%]
难治性双相抑郁患者短期氯胺酮治疗无效应答者的欣快感缺失症状
Zofia Kachlik,Wiesław Jerzy Cubała,Michał Walaszek et al.
Zofia Kachlik et al.
Background: Anhedonia is a key symptom of bipolar depression and a target of ketamine's rapid antidepressant effects. However, many patients with treatment-resistant bipolar depression (TRBD) do not respond. ...
Adjunctive treatment with evenamide, a glutamate modulator, is associated with clinically meaningful benefits in patients with treatment-resistant schizophrenia and inadequate response to antipsychotics: recent clinical findings from randomized trials [0.03%]
谷氨酸调节剂依文拉明作为增效治疗手段可帮助难治性精神分裂症患者改善症状：随机试验的最新临床结果
Ravi Anand,Alessio Turolla,Giovanni Chinellato et al.
Ravi Anand et al.
Background: Despite their efficacy in improving positive symptoms, first- and second-generation antipsychotics (FGAs and SGAs) fail to provide benefit to a large portion of patients with schizophrenia. Evenamide, uniquely...
A description of antipsychotic prescribing patterns on the inpatient behavioral health setting: a multicenter cross-sectional analysis [0.03%]
我国多家医疗机构精神科住院病房抗精神病药物处方特征的多中心横断面研究描述性分析
Thomas Maestri,David Anderson,Margarita Echeverri
Thomas Maestri
Background: Antipsychotic therapy can bring a great deal of benefit to individuals with schizophrenia and other psychiatric diagnoses, though this class of medications is also associated with intolerabilities due to possi...
Acute and persistent withdrawal syndromes following discontinuation of antidepressants in children and adolescents: a systematic review [0.03%]
儿童及青少年停用抗抑郁药后出现的急性及持续性戒断综合征：系统评价研究报告
Jianjun Wang,Fiammetta Cosci
Jianjun Wang
Antidepressants are commonly prescribed for children and adolescents, but their discontinuation may result in withdrawal symptoms, though rarely described for this age group in the literature. Systematically examining the types and prevalen...
Effects of glucagon-like peptide-1 receptor agonists on psychiatric disorders: a systematic review [0.03%]
胰高血糖素样肽-1受体激动剂对精神疾病影响的系统评价
Serene Lee,Liyang Yin,Kayla M Teopiz et al.
Serene Lee et al.
Extant literature pertaining to the administration of glucagon-like peptide-1 receptor agonists (GLP-1RAs) for Alzheimer's disease, Parkinson's disease, major depressive disorder, bipolar disorder, substance-, alcohol- and nicotine-use diso...
Predicting rTMS treatment response in schizophrenia using interpretable machine learning: a SHAP-based analysis [0.03%]
基于SHAP的分析：使用可解释机器学习预测精神分裂症rTMS治疗反应
Jingyuan Lin
Jingyuan Lin
Background: Individual responses to repetitive transcranial magnetic stimulation (rTMS) in schizophrenia vary, and predictive clinical tools are lacking. ...
From model psychosis to rapid antidepressant: a historical and conceptual review of ketamine's psychiatric history [0.03%]
从模型精神病到快速抗抑郁剂：氯胺酮的精神病学历史的历史和概念回顾
Casimiro Cabrera Abreu,Aleksandar Biorac,Ross J Baldessarini et al.
Casimiro Cabrera Abreu et al.
Ketamine's development in psychiatry exemplifies the evolution of psychopharmacology over six decades. Originally introduced as a dissociative anesthetic and psychotomimetic probe, ketamine has been repositioned as a rapidly acting antidepr...
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial [0.03%]
持续性抑郁患者微量服用LSD体验的质性研究
Carina Joy Donegan,Dimitri Daldegan-Bueno,Rachael L Sumner et al.
Carina Joy Donegan et al.
Background: Depressive disorders affect approximately 280 million globally, with many finding treatments ineffective or limited by side effects. Growing evidence suggests that psychedelic therapies may help alleviate depr...