Oestrogen modulators as augmentation to antipsychotics for the treatment of post- and perimenopausal psychosis: a systematic review [0.03%]
雌激素调节剂联合抗精神病药治疗围绝经期和绝经后精神障碍的系统性回顾研究
Cassidy Keen,Athanasios Hassoulas,Jill Richardson
Cassidy Keen
Background: It is theorised that oestrogen provides neuroprotection against psychosis. Oestrogen levels drop during post- and perimenopausal periods, creating a window for the onset of psychotic symptoms. Oestrogen treatm...
Seizures associated with clozapine augmentation by other antipsychotics: a pharmacovigilance-pharmacodynamic analysis using VigiBase [0.03%]
利用VigiBase进行药学警戒-药理动力学分析：其他抗精神病药物联合氯氮平治疗与癫痫发作的关系
Masakazu Hatano,Hirofumi Hamano,Masaya Kanda et al.
Masakazu Hatano et al.
Background: Clozapine is associated with a high risk of central nervous system abnormalities. However, seizure risk related to interactions between clozapine and other antipsychotics remains poorly characterized, and the ...
Conceptual analysis of mechanisms and methods in psychedelic clinical trial design: a narrative review [0.03%]
经典试临床设计中的机制和方法的概念分析：叙述性综述
Martin Krsak,David Sparrow,Bernard Rosner et al.
Martin Krsak et al.
Clinical trials with psychedelics face several challenges that are not present to such a degree with other pharmacotherapeutics. Psychedelic therapies often include a significant therapeutic container, including preparatory and integrative ...
Madeleine Bloomfield,Lily Chebabo-Manning,Rebecca Strawbridge
Madeleine Bloomfield
Background: Lithium is widely recognized for its benefits as a medication to treat mood disorders. Low-dose lithium has been commercially available for decades as a nutritional supplement, but there is little research on ...
Lithium in the management of suicide: a formidable force in the fight against a fatal foe [0.03%]
锂元素在自杀行为管理中的作用：应对致命威胁的强大武器
Gurubhaskar Shivakumar,Kinga Szymaniak,Erica Bell et al.
Gurubhaskar Shivakumar et al.
Patterns of antidepressant treatment changes among adults with major depressive disorder in Northwest Ethiopia: a hospital-based cross-sectional study [0.03%]
埃塞俄比亚西北部成年人重大抑郁障碍的抗抑郁治疗模式变化：基于医院的横断面研究
Tilaye Arega Moges,Fasil Bayafers Tamene,Woretaw Sisay Zewdu et al.
Tilaye Arega Moges et al.
Background: Major depressive disorder (MDD) is a prominent cause of worldwide disability, severely affecting quality of life in Ethiopia. Despite a significant prevalence of treatment-resistant depression, challenges in t...
Making a case for using MDMA-assisted psychotherapy for borderline personality disorder and complex PTSD: a descriptive systematic review of the literature [0.03%]
关于使用MDMA辅助心理疗法治疗边缘型人格障碍和复杂PTSD的文献综述性研究描述性的系统回顾
Karthika Kasiviswanathan,Dinuli Nilaweera,Melissa Morando et al.
Karthika Kasiviswanathan et al.
Background: 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy (MDMA-AP) has demonstrated considerable efficacy in treating post-traumatic stress disorder (PTSD). PTSD and complex PTSD (CPTSD) frequently co-o...
Identifying patients at risk of supratherapeutic amisulpride exposure in routine psychiatric practice: a real-world therapeutic drug monitoring study [0.03%]
一项真实世界治疗药物监测研究：识别日常精神病学实践中易发生 amisulpride 超剂量暴露的患者
Keyu Yan,Gehang Ju,Aowei Li et al.
Keyu Yan et al.
Background: Amisulpride is an important antipsychotic used in the treatment of schizophrenia, yet its exposure shows inter-individual variability. Although therapeutic drug monitoring (TDM) is recommended, supratherapeuti...
Ketamine alters the aperiodic EEG exponent in major depression: implications for cortical E/I balance and treatment prediction [0.03%]
氯胺酮改变抑郁症患者的非周期性脑电指数：皮层兴奋和抑制平衡及预测治疗效果的含义
Yujuan Liu,Xiaorong Liu,Sebastian Olbrich et al.
Yujuan Liu et al.
Background: Ketamine has emerged as a promising rapid-acting antidepressant for treatment-resistant depression (TRD), yet its mechanisms of action and reliable biomarkers of treatment response remain poorly understood. Re...
Assessment of clozapine taste in healthy volunteers: evidence for non-aversive sensory profile [0.03%]
健康受试者氯氮平味道评估：非厌恶感觉特征证据
Laura Modica de Mohac,Alex Keeley,David Taylor et al.
Laura Modica de Mohac et al.
Background: Acceptability is crucial for treatment efficacy, and the World Health Organization emphasizes its impact on patient compliance. Taste plays a significant role in acceptability, with bitter taste often leading ...