Plain Language Summary of Publication: What experts agree about using long-acting injectable antipsychotic medicine for people early in their experience of schizophrenia [0.03%]
关于使用长效抗精神病药物治疗首次发病的精神分裂症患者的专家共识简述
Andrea Fagiolini,Murat Yildirim,Celso Arango et al.
Andrea Fagiolini et al.
What is this summary about? Antipsychotics are a type of medicine used to treat the symptoms of schizophrenia. These medicines come in various forms, including long-acting injectables (LAIs), which are taken every few weeks or months. There...
The acute effects of Zensera™ (Melissa officinalis L.) extract on mood and cognitive performance during cognitive overload: a randomised placebo-controlled, double-blind study in healthy young adults with moderate subjective stress [0.03%]
富含 Melissa officinalis L. 的 ZenSera™ 对认知超载期间情绪和认知表现的急性影响：对主观压力中等的健康年轻成年人的随机双盲安慰剂对照试验
Imogen Mathews,Jessica Eastwood,Lynne Bell et al.
Imogen Mathews et al.
Background: Chronic cognitive overload strains working memory and activates the body's stress response via the hypothalamic-pituitary-adrenocortical axis, potentially causing stress-related health issues. Over-the-counter...
Predicting the blood concentration of levetiracetam in people with epilepsy using machine learning and real-world data [0.03%]
基于真实世界数据和机器学习预测癫痫患者左乙拉西坦血药浓度
Bolin Zhu,Nan Zheng,Di Chen et al.
Bolin Zhu et al.
Background: Levetiracetam is an antiepileptic drug widely used to treat partial and generalized seizures in clinicians. The effectiveness and safety of levetiracetam in individuals with epilepsy are affected by various co...
The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan [0.03%]
五羟色胺综合征与抗利尿激素不适当分泌综合征的相互作用：在治疗期间使用度洛西汀、氯苯那敏、阿米替林和L-色氨酸时发生急性低钠血症的致命病例
Donato Morena,Salvatore Silvio Colonna,Alessandro Santurro et al.
Donato Morena et al.
Serotonin syndrome (SS) and hyponatremia are severe, potentially life-threatening adverse reactions to serotonergic medications. Their concurrent manifestation is rare but clinically significant due to overlapping pathophysiological mechani...
Sympathetic activation but not dissociation linked to ketamine's sustained antidepressant effect [0.03%]
同情素激活而非解离与氯胺酮的持久抗抑郁作用有关
Veronika Andrashko,Tomas Novak,Miloslav Kopecek et al.
Veronika Andrashko et al.
Background: Ketamine is a rapid-acting antidepressant with robust evidence, but unclear predictors of therapeutic response. Objectives: ...
Sodium-glucose cotransporter-2 inhibitors lower risk of kidney replacement therapy and mortality in bipolar disorder with chronic kidney disease [0.03%]
钠-葡萄糖共转运蛋白-2抑制剂可降低Ⅱ型糖尿病合并慢性肾脏病患者进入终末期肾病和死亡风险
Balwinder Singh,Maria L Gonzalez Suarez,Ritika Baweja et al.
Balwinder Singh et al.
Background: Bipolar disorder (BD) is associated with a higher prevalence of chronic kidney disease (CKD) and increased mortality, yet individuals with both BD and CKD are less likely to receive kidney replacement therapy ...
Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients [0.03%]
利拉鲁肽与二甲双胍、纳曲酮/安非他酮和芬特明/托吡酯在精神疾病患者中的疗效和安全性比较
Won-Seok Choi,Min-Kyu Song,Mansuk Seo et al.
Won-Seok Choi et al.
Background: Psychiatric patients have a high risk of obesity, frequently due to psychotropic medication-induced weight gain. However, real-world comparative data on antiobesity medications (AOMs) in this population remain...
Lithium nephrotoxicity: a systematic review and meta-analysis of lithium versus non-lithium control studies in patients with affective disorders [0.03%]
锂中毒的系统性评审及meta分析：与情感障碍患者中非锂药物对照研究中的肾脏毒性研究综述及元分析
Marie Michele Macaron,Mireilla Abou Rjeily,Raphael Macaron et al.
Marie Michele Macaron et al.
Background: Lithium, the gold standard treatment of bipolar disorder (BD), is thought to cause nephropathy in long-term users. However, the role of confounding variables linked to BD in exerting this adverse effect remain...
Sex, drugs, and arousal-two randomized trials on the effects of ketamine on sexual arousal and calcarine gyrus activity [0.03%]
关于氯胺酮对性唤起和距状回活动的影响的两项随机试验
Manfred Klöbl,Thomas Liebe,Gregor Dörl et al.
Manfred Klöbl et al.
Background: Ketamine, a well-established antidepressant and dissociative anesthetic, is also used recreationally in the club and chemsex scene. Survey and qualitative data suggest that while ketamine facilitates chemsex e...
Impact of treatment with long‑acting injectable antipsychotics on hospitalization and relapse rates in schizophrenia spectrum disorders: a 3‑year follow-up mirror‑image study [0.03%]
长效抗精神病药物治疗对精神分裂症谱系障碍住院率和复发率的影响：为期3年的镜像研究
Renato de Filippis,Matteo Aloi,Alfredo Cimino et al.
Renato de Filippis et al.
Background: Long-acting injectable (LAI) antipsychotics are an important treatment option for the long-term treatment management of schizophrenia spectrum disorders (SSDs). Emerging evidences suggest a beneficial impact o...