Primary brain tumor patients admitted to a US intensive care unit: a descriptive analysis [0.03%]
被收入美国重症监护病房的主要脑肿瘤患者：描述性分析
Jennifer H Kang,Christa B Swisher,Evan D Buckley et al.
Jennifer H Kang et al.
Purpose: To describe our population of primary brain tumor (PBT) patients, a subgroup of cancer patients whose intensive care unit (ICU) outcomes are understudied. Methods: Retrospective analysis of PBT patients admitted to an ICU between 2...
Identifying the optimal cutoff point for MGMT promoter methylation status in glioblastoma [0.03%]
确定胶质母细胞瘤中MGMT启动子甲基化状态的最佳临界值
Ngan Nguyen,Jordan Redfield,Matthew Ballo et al.
Ngan Nguyen et al.
Aim: To define the optimal cutoff point for determining methylation status of O6-methylguanine-DNA methyltransferase (MGMT) by pyrosequencing in glioblastoma. Patients & methods: A retrospective study of 109 glioblastoma patients was perfor...
Tanvi Nadkarni,Kimberly Hamilton,Faraze Niazi et al.
Tanvi Nadkarni et al.
Glioblastoma multiforme is the most common malignant primary brain tumor in adults. Histone H3 mutations have been identified in pediatric and adult gliomas, with H3K27M mutations typically associated with a posterior fossa midline tumor lo...
Case Reports
CNS oncology. 2021 Sep 1;10(3):CNS75. DOI:10.2217/cns-2021-0008 2021
Treatment patterns and outcomes for patients with newly diagnosed glioblastoma multiforme: a retrospective cohort study [0.03%]
新诊断出胶质母细胞瘤患者的治疗模式和结局：一项回顾性队列研究
Srinivas Annavarapu,Anagha Gogate,Trang Pham et al.
Srinivas Annavarapu et al.
Aim: Investigate real-world outcomes and healthcare utilization of patients with glioblastoma multiforme (GBM) related to O6-methylguanine DNA methyltransferase (MGMT) promoter testing and methylation. Patients & methods: US Oncology Networ...
Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma [0.03%]
下一代测序发现胶质母细胞瘤与脑膜瘤碰撞肿瘤的新突变
Kelly Chamberlin,Gregory Chamberlin,Katherine Saunders et al.
Kelly Chamberlin et al.
Primary intracranial collision tumors are rare in patients without predisposing factors. We report such a case in a 42-year-old female who presented with headaches and altered mental status. Imaging revealed a single heterogeneous, rim-enha...
Case Reports
CNS oncology. 2021 Jun 1;10(2):CNS70. DOI:10.2217/cns-2020-0029 2021
Meningioma: not always a benign tumor. A review of advances in the treatment of meningiomas [0.03%]
脑膜瘤并非总是良性肿瘤——治疗进展回顾
Ilaria Maggio,Enrico Franceschi,Alicia Tosoni et al.
Ilaria Maggio et al.
Meningiomas are the most common primary intracranial tumors. The majority of meningiomas are benign, but they can present different grades of dedifferentiation from grade I to grade III (anaplastic/malignant) that are associated with differ...
Anda-Alexandra Calinescu,McKenzie C Kauss,Zain Sultan et al.
Anda-Alexandra Calinescu et al.
Glioblastoma, the deadliest form of primary brain tumor, remains a disease without cure. Treatment resistance is in large part attributed to limitations in the delivery and distribution of therapeutic agents. Over the last 20 years, numerou...
Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman [0.03%]
一例83岁老年女性H3K27M突变弥漫中线胶质瘤病例报告
Justin Thomas Low,Shih-Hsiu Wang,Katherine B Peters
Justin Thomas Low
Diffuse midline gliomas harboring histone H3 K27M mutations are most commonly found in the brainstem of children. This mutation confers a WHO grade IV designation and is associated with a particularly poor prognosis. Although traditionally ...
Case Reports
CNS oncology. 2021 Jun 1;10(2):CNS71. DOI:10.2217/cns-2020-0030 2021
When tumefactive demyelination is truly a tumor: case report of a radiographic misdiagnosis [0.03%]
肿瘤样脱髓鞘病变一例临床及影像学误诊报道
Breanna Taylor,Mallika P Patel,Katherine B Peters
Breanna Taylor
Oligodendrogliomas are slow-growing tumors that account for 15-20% of gliomas. This case report describes the case of an adult male patient diagnosed initially with tumefactive demyelination and multiple sclerosis, which was subsequently fo...
Case Reports
CNS oncology. 2021 Mar 1;10(1):CNS69. DOI:10.2217/cns-2020-0028 2021
Adult pilocytic astrocytoma in the molecular era: a comprehensive review [0.03%]
分子时代的成人毛细胞星形细胞瘤综合述评
Timothy A Gregory,Lyndon B Chumbley,John W Henson et al.
Timothy A Gregory et al.
Adult pilocytic astrocytoma (PA) is less prevalent than pediatric PA and is associated with a worse prognosis. In a literature review, we found that 88.3% of the molecular alterations in adult PA are associated with MAPK pathway dysregulati...