Diffuse pediatric-type high grade glioma, RTK1 subtype, subclass C with SYN2:: PPARG fusion in an older adult [0.03%]
成人散发型儿童高级别胶母RTK1亚型C低级别转化伴SYN2::PPARA融合基因变异
Mikaela N Brentlinger,Jemini Patel,Ahmed Khan et al.
Mikaela N Brentlinger et al.
Diffuse pediatric-type high-grade glioma (pHGG), RTK1 subtype, is an uncommon aggressive tumor affecting both children and adults. We describe the case of a 66-year-old woman who presented with a left frontal lobe mass. Following surgical r...
Case Reports
CNS oncology. 2026 Dec;15(1):2641996. DOI:10.1080/20450907.2026.2641996 2026
Synchronous diagnosis of multicentric glioma with distinct isocitrate dehydrogenase molecular profiles: a case report [0.03%]
具有不同异柠檬酸脱氢酶分子特征的多中心胶质瘤同步诊断一例报告
Aditya A Mohan,Kristen Batich,Shih-Hsiu J Wang et al.
Aditya A Mohan et al.
This case report characterizes the molecular pathology of two synchronous IDH mutant gliomas in a 28-year-old female patient. The patient exhibited symptoms of dizziness, retro-orbital pain, headache, and numbness with paresthesia in her ri...
Case Reports
CNS oncology. 2026 Dec;15(1):2626299. DOI:10.1080/20450907.2026.2626299 2026
Impact of radiation fractionation on pseudoprogression in older patients with glioblastoma: a retrospective cohort study [0.03%]
放射分次照射对老年胶质母细胞瘤患者的假进展影响的队列研究
Derek L Chien,Sara J Hardy,Jennifer N Serventi et al.
Derek L Chien et al.
Aims: We aimed to investigate a potential association between hypofractionated radiotherapy (HFRT) vs. conventional radiotherapy (CRT) and development of pseudoprogression in patients over the age of 65 treated for gliobl...
Surgical decision making in the era of supramarginal glioma resections: a current perspective and narrative review [0.03%]
超边缘胶质瘤切除时代的手术决策：当前视角和叙述性回顾
Max O Krucoff
Max O Krucoff
Whether to surgically resect a margin of grossly normal appearing brain around anatomically amenable diffuse gliomas (i.e., perform a supratotal, supramarginal, or supramaximal resection) has been controversial. Over the past 5-10 years, ho...
Sustained response to larotrectinib in a pediatric patient with recurrent STRN3::NTRK2 fusion-positive pilocytic astrocytoma [0.03%]
larotrectinib治疗STRN3::NTRK2阳性复发性乳头状星形细胞瘤儿科患者的良好疗效持续一年以上
Kishore Balasubramanian,Kar-Ming Fung,Rene Y McNall-Knapp et al.
Kishore Balasubramanian et al.
A 7-year-old female with recurrent midline pilocytic astrocytoma harboring a rare STRN3::NTRK2 fusion achieved sustained near-complete radiographic and clinical response to larotrectinib, a selective TRK inhibitor. Initial subtotal resectio...
Case Reports
CNS oncology. 2025 Dec;14(1):2558455. DOI:10.1080/20450907.2025.2558455 2025
Multiple brain lesions in a patient with relapsed hairy cell leukemia: a case report and review of the literature [0.03%]
复发性毛细胞白血病患者的多发脑内病变一例及文献复习
Katell Le Dû,Jacques Delaunay,Maud Voldoire et al.
Katell Le Dû et al.
Cerebral lesions are rare in hairy cell leukemia (HCL), and its incidence remains to be determined. Identifying the cause can be challenging. In this report, we present a case of brain lesions occurring several years after diagnosis. A 76-y...
Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype [0.03%]
具有高度粘附性放射状胶质细胞表型的复发性胶质母细胞瘤细胞的非典型行为
Manjusha Vaidya,Jonhoi Smith,Julia Pessaia et al.
Manjusha Vaidya et al.
Glioblastoma (GBM) is the most common malignant primary brain tumor, characterized by a high recurrence rate despite aggressive therapy. We present a case of a 32-year-old male with a recurrent WHO Grade IV IDH1-mutant astrocytoma after und...
Case Reports
CNS oncology. 2025 Dec;14(1):2559576. DOI:10.1080/20450907.2025.2559576 2025
Complete resection of a giant epidermoid cyst of the occipital bone: case report and systematic review [0.03%]
巨大枕骨表皮样囊肿完整切除术：1例报告及系统回顾
Ishwarya Nair,Adrian Zammit,Timothy Williamson et al.
Ishwarya Nair et al.
Epidermoid cysts are uncommon accounting for less than 1% of all intracranial tumors. Among them, giant intradiploic epidermoid cysts of the posterior fossa i.e. those exceeding 5 cm are an even rarer entity. Here we report on the complete ...
Radio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma [0.03%]
放射影像-病理估计的细胞生长动力学可预测胶质母细胞瘤复发患者的生存率
Sonoko Oshima,Jingwen Yao,Samuel Bobholz et al.
Sonoko Oshima et al.
Aim: A radio-pathomic machine learning (ML) model has been developed to estimate tumor cell density, cytoplasm density (Cyt) and extracellular fluid density (ECF) from multimodal MR images and autopsy pathology. In this multicenter study, w...
Multicenter Study
CNS oncology. 2024 Dec 31;13(1):2415285. DOI:10.1080/20450907.2024.2415285 2024
Andrew Timothy Ng,Tyler Steve,Kevin T Jamouss et al.
Andrew Timothy Ng et al.
Glioblastoma is associated with a dismal prognosis with the standard of care involving surgery, radiation therapy and temozolomide chemotherapy. This review investigates the features that make glioblastoma difficult to treat and the results...