Novel therapeutic delivery approaches in development for pediatric gliomas [0.03%]
目前在研的儿童脑胶质瘤治疗递送新方法
Katherine E Warren
Katherine E Warren
Pediatric gliomas are a heterogeneous group of diseases, ranging from relatively benign pilocytic astrocytomas with >90% 5-year survival, to glioblastomas and diffuse intrinsic pontine gliomas with
James S Hale,Maksim Sinyuk,Jeremy N Rich et al.
James S Hale et al.
Our understanding of the complexity of nervous system cancers has been enhanced through the incorporation of cellular heterogeneity into tumor models, with cellular subsets displaying stem cell characteristics. Advanced cancers such as glio...
Role of stereotactic radiosurgery in patients with more than four brain metastases [0.03%]
立体放射外科手术在四枚以上脑转移灶患者中的作用
Vikram Jairam,Veronica L S Chiang,James B Yu et al.
Vikram Jairam et al.
For patients presenting with brain metastases, two methods of radiation treatment currently exist: stereotactic radiosurgery (SRS) and whole-brain radiation therapy (WBRT). SRS is a minimally invasive to noninvasive technique that delivers ...
Lipid metabolism emerges as a promising target for malignant glioma therapy [0.03%]
脂质代谢成为恶性胶质瘤治疗的有希望的目标
Deliang Guo,Erica Hlavin Bell,Arnab Chakravarti
Deliang Guo
Malignant gliomas are one of the most treatment-refractory cancers. Development of resistance to chemo- and radio-therapies contributes to these tumors' aggressive phenotypes. Elevated lipid levels in gliomas have been reported for the last...
Ryan Cordner,Keith L Black,Christopher J Wheeler
Ryan Cordner
Glioblastoma multiforme (GBM) is a malignant neoplasm of the CNS with almost uniform lethality. Even with standard-of-care treatments, the prognosis for patients remains dismal. GBM, as with other malignancies, often acquires treatment resi...
Diffusion-weighted MRI as a biomarker for treatment response in glioma [0.03%]
扩散加权MRI在胶质瘤治疗反应中的生物标志物作用
Kathleen M Schmainda
Kathleen M Schmainda
Diffusion-weighted imaging (DWI) is a powerful MRI method, which probes abnormalities of tissue structure by detecting microscopic changes in water mobility at a cellular level beyond what is available with other imaging techniques. Accordi...
Severity, etiology and possible consequences of treatment-related lymphopenia in patients with newly diagnosed high-grade gliomas [0.03%]
新诊断的高级别胶质瘤患者的治疗相关性淋巴细胞减少症的严重程度、病因及可能的治疗后果
Susannah Yovino,Stuart A Grossman
Susannah Yovino
Lymphopenia is a common consequence of therapy for malignant glioma. Current standard therapy includes corticosteroids, temozolomide and radiation therapy, all of which are toxic to lymphocytes. The resulting immunosuppression has serious c...
Kan V Lu,Gabriele Bergers
Kan V Lu
Angiogenesis inhibitors targeting the VEGF signaling pathway have been US FDA approved for various cancers including glioblastoma (GBM), one of the most lethal and angiogenic tumors. This has led to the routine use of the anti-VEGF antibody...
Combinatorial strategies for oncolytic herpes simplex virus therapy of brain tumors [0.03%]
溶瘤疱疹病毒治疗脑肿瘤的组合策略研究进展
Ryuichi Kanai,Samuel D Rabkin
Ryuichi Kanai
Oncolytic viruses, such as the oncolytic herpes simplex virus (oHSV), are an exciting new therapeutic strategy for cancer as they are replication competent in tumor cells but not normal cells. In order to engender herpes simplex virus with ...