Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle [0.03%]
成人骨骼肌在机械负载下移位的细胞核来源于居室内核迁移和干细胞融合
Nathan Serrano,Pieter Jan Koopmans,Kevin A Murach
Nathan Serrano
Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity of muscle stem cells, or sate...
The metabolic role of corticotropin-releasing hormone receptor 2 and its UCN peptides: emerging therapeutic potential [0.03%]
促肾上腺皮质激素释放激素受体2及其乌尔克肽的代谢作用及潜在治疗价值
Pablo Vidal,Natalie Janzen,Joseph T Brozinick
Pablo Vidal
Skeletal muscle is a highly plastic tissue that plays a crucial role in overall metabolic health, and in diseases such as obesity and type 2 diabetes. Recently, the importance of preserving muscle mass during weight loss has gained apprecia...
Complement-independent pathogenic influences of anti-HMGCR + and anti-SRP + immune-mediated necrotizing myopathy autoantibodies on engineered muscle function [0.03%]
补体非依赖性的抗HMGCR和抗SRP自身免疫性坏死性肌炎抗体对工程化肌肉功能的病理性影响
Heta Lad,Yekaterina Tiper,Ernest Myguel Esteban et al.
Heta Lad et al.
Background: Immune-mediated necrotizing myopathy (IMNM) is a subgroup of idiopathic inflammatory myopathies associated with anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) a...
FLASH: innovative integrated enzymatic-fluorescent labeling for automated muscle fiber typing, metabolic and morphometric analysis [0.03%]
新型集成酶荧光标记技术在肌肉纤维分型、代谢和形态计量分析中的应用（Flash）
Maxime Di Gallo,Thomas Guilbert,Doriane Pereira et al.
Maxime Di Gallo et al.
Background: Skeletal muscle is a dynamic tissue capable of structural and metabolic remodeling in response to physiological and pathological stimuli. These adaptations are central to understanding the mechanisms underlyin...
Pirfenidone treatment improves ischemic muscle function in mice with chronic kidney disease [0.03%]
吡非尼酮治疗可改善慢性肾脏病小鼠的缺血性肌肉功能
Nicholas Balestrieri,Gengfu Dong,Terence E Ryan
Nicholas Balestrieri
Chronic kidney disease (CKD) and peripheral artery disease (PAD) frequently coexist and synergistically exacerbate skeletal muscle dysfunction, contributing to limb function impairment and increased risk of amputation and mortality. Both di...
TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging [0.03%]
TET在果蝇飞行肌肉发育和衰老过程中的酶活性依赖和非依赖功能显示
Vincent Gerdy,Emilie Plantié,Romane Bertrand et al.
Vincent Gerdy et al.
Background: Enzymes of the Ten-Eleven Translocation family are responsible for 5-methylcytosine (5mC) oxidation and play a key role in regulating DNA demethylation during various developmental processes, including myogene...
Signaling networks governing skeletal muscle growth, atrophy, and cachexia : By [0.03%]
调控骨骼肌生长、萎缩和恶病质的信号网络：综述文章
Aniket S Joshi,Meiricris Tomaz da Silva,Savita Kumar et al.
Aniket S Joshi et al.
Maintaining skeletal muscle mass and strength is essential for healthy aging and overall longevity. Muscle mass is governed by a complex network of signaling pathways that coordinate proteostasis and regulate the expression of anabolic and ...
Integrated fibre-specific methylome and proteome profiling of human skeletal muscle across males and females with fibre-type deconvolution [0.03%]
基于肌纤维类型脱混的人类骨骼肌纤维特异性甲基组和蛋白质组综合分析
Andrew S Palmer,Esther García-Domínguez,Megan F Taylor et al.
Andrew S Palmer et al.
Background: Skeletal muscle is an important organ for health and movement, largely driven by specific muscle fibres. However, the comparison of fibre-type-specific DNA methylation and protein abundance from the same sampl...
Spatiotemporal analysis of dystrophin expression during muscle repair [0.03%]
肌营养不良蛋白在肌肉修复过程中的时空表达分析
John C W Hildyard,Liberty E Roskrow,Dominic J Wells et al.
John C W Hildyard et al.
Background: Dystrophin mRNA is produced from a very large genetic locus and transcription of a single mRNA requires approximately 16 h. This prolonged interval between initiation and completion results in unusual transcri...
Spatiotemporal analysis of dystrophin expression during muscle repair [0.03%]
肌营养不良蛋白在肌肉修复过程中的时空表达分析
John C W Hildyard,Liberty E Roskrow,Dominic J Wells et al.
John C W Hildyard et al.
Background: Dystrophin mRNA is produced from a very large genetic locus and transcription of a single mRNA requires approximately 16 h. This prolonged interval between initiation and completion results in unusual transcri...