Zahra Zamani,Alireza Sadeghi Tafreshi,Hossein Nahrevanian et al.
Zahra Zamani et al.
The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common lab...
Clinical efficacy of artemether-lumefantrine in congolese children with acute uncomplicated falciparum malaria in brazzaville [0.03%]
科特迪瓦布拉柴维尔儿童急性无并发症恶性疟疾患者服用 Artekin 救治的临床疗效分析
Mathieu Ndounga,Rachida Tahar,Prisca N Casimiro et al.
Mathieu Ndounga et al.
The Republic of the Congo adopted artemisinin-based combination therapies (ACTs) in 2006: artesunate-amodiaquine and artemether-lumefantrine as the first-line and second-line drugs, respectively. The baseline efficacy of artemether-lumefant...
Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF-κB Translocation in a Mechanism Independent of Plasmodium Killing [0.03%]
Arte sunshine 对内皮细胞活化和NF- κB 传递具有直接作用且与杀灭疟原虫无关的机制
Mariana C Souza,Flávio Henrique Marcolino Paixão,Fausto K Ferraris et al.
Mariana C Souza et al.
Artemisinin and its derivates are an important class of antimalarial drug and are described to possess immunomodulatory activities. Few studies have addressed the effect of artesunate in the murine malaria model or its effect on host immune...
In Vitro Chloroquine Resistance in Plasmodium falciparum Isolates from Tertiary Care Hospital [0.03%]
来源于三级医院的恶性疟原虫株体外氯喹耐药性研究
Fatima Shujatullah,Haris M Khan,Abida Khatoon et al.
Fatima Shujatullah et al.
Chloroquine (CQ) has been the mainstay of treatment of malaria for decades. This cost-effective and safe drug has become ineffective for treatment of falciparum malaria in many parts of the world due to development of resistance by the para...
Subacute therapeutic dosing of artemether-lumefantrine and artesunate-amodiaquine combination preserves plasma cholesterol, renal antioxidant status, and organ weights in rats [0.03%]
蒿甲醚-卢宁芬净和artequine-氨酚喹组合的亚急性治疗剂量可保持大鼠血浆胆固醇，肾抗氧化状态和器官重量
Chiagoziem A Otuechere,Gloria Edewor,Oluwafemi Ezekiel Kale et al.
Chiagoziem A Otuechere et al.
Recent instances of breakdowns of malaria control programs and the constant emergence of drug-resistant parasites to monotherapies have shored up the use of artemisinin-based combination therapy (ACT) as the malaria therapy of choice. We ev...
Shiraz Jamal Khan,Yasir Abbass,Mumtaz Ali Marwat
Shiraz Jamal Khan
Objectives. To evaluate the predictive value of thrombocytopenia in malaria. Patients and Methods. It was a prospective observational study on all febrile patients with thrombocytopenia presenting to the Medical Unit of Hayat Abad Medical C...
Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice [0.03%]
氯喹和-artesunate-对感染的白鼠体内四种重要器官造成-Plasmodium berghei-组织病理损伤的影响比较研究
O T Soniran,O A Idowu,O L Ajayi et al.
O T Soniran et al.
The aim of the present study was to investigate the positive influence of chloroquine and artesunate on the pathological damages caused by Plasmodium berghei on vital organs of mice in an established infection. Healthy adult albino mice wit...
Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon [0.03%]
氯喹和伯氨喹方案治疗秘鲁亚马逊地区马来亚疟的失败案例
Paul C F Graf,Salomon Durand,Carlos Alvarez Antonio et al.
Paul C F Graf et al.
The widespread use of primaquine (PQ) and chloroquine (CQ), together, may be responsible for the relatively few, isolated cases of chloroquine-resistant P. vivax (CQRPV) that have been reported from South America. We report here a case of P...
Therapeutic Efficacy of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Northern Ethiopia [0.03%]
青蒿琥酯-卢梅夫林治疗北埃塞俄比亚恶性疟的疗效研究
Gebremedhin Kinfu,Solomon Gebre-Selassie,Nigus Fikrie
Gebremedhin Kinfu
Introduction. Multidrug resistance of Plasmodium falciparum is spreading throughout Africa. This has posed major challenges to malaria control in sub-Saharan Africa. Objective. The aim of the study was to evaluate the efficacy of artemether...
In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice [0.03%]
携带Plasmodium berghei的小鼠在清除疟原虫后的体内血红素生物 kinetics 研究
Rosangela Frita,Daniel Carapau,Maria M Mota et al.
Rosangela Frita et al.
Hemozoin (Hz) is released into the blood stream after rupture of infected red blood cells (iRBCs) at the end of each parasite replication cycle. This free Hz is ingested by circulating and resident phagocytes. The presence of Hz in tissues ...