The metabolic activity of gut microbiota in obese children is increased compared with normal-weight children and exhibits more exhaustive substrate utilization [0.03%]
肥胖儿童的肠道微生物代谢活性增强并表现出更彻底的底物利用能力：与正常体重儿童相比
A N Payne,C Chassard,M Zimmermann et al.
A N Payne et al.
Objective: The gut microbiota contribute otherwise impossible metabolic functions to the human host. Shifts in the relative proportions of gut microbial communities in adults have been correlated with intestinal disease a...
Central obesity and smoking are key modifiable risk factors for elevated C-reactive protein in Asian individuals who are not eligible for statin therapy [0.03%]
中心性肥胖和吸烟是亚洲非他汀治疗人群中高敏感C反应蛋白的主要可控危险因素
C M Khoo,M Tan,Y Wu et al.
C M Khoo et al.
Objective: Statin therapy reduces coronary heart disease (CHD) and mortality in individuals with elevated C-reactive protein (CRP) but low-density lipoprotein cholesterol below the threshold at which statin therapy is rec...
Dietary lipid-dependent regulation of de novo lipogenesis and lipid partitioning by ketogenic essential amino acids in mice [0.03%]
生酮必需氨基酸在小鼠中的从头合成脂质生成和脂质分布的调节取决于饮食中的脂质含量
N Nishikata,N Shikata,Y Kimura et al.
N Nishikata et al.
Background: We have previously reported that dietary ketogenic amino acids (KAAs) modulate hepatic de novo lipogenesis (DNL) and prevent hepatic steatosis in mice. However, the dependence of the metabolic phenotypes gener...
Effect of PGX, a novel functional fibre supplement, on subjective ratings of appetite in overweight and obese women consuming a 3-day structured, low-calorie diet [0.03%]
PGX，一种新型的功能性膳食纤维补充剂对体重超重或肥胖的女性在食用三天结构化的低卡路里饮食的情况下产生的主观饱腹感的影响研究
V Kacinik,M Lyon,M Purnama et al.
V Kacinik et al.
Introduction: Dietary factors that help control perceived hunger might improve adherence to calorie-reduced diets. Objectives: The obje...
Angiopoietin-like protein 2 sensitively responds to weight reduction induced by lifestyle intervention on overweight Japanese men [0.03%]
血管生成素样蛋白2敏感地响应由生活方式干预引起的日本超重男性的体重减轻反应
A Muramoto,K Tsushita,A Kato et al.
A Muramoto et al.
Objective: Overexpression of Angiopoietin-like protein 2 (Angptl2) in obese adipose tissues promotes adipose tissue inflammation and its-related metabolic abnormalities. In a comparative study with adiponectin, we investi...
Impaired hypothalamic Fto expression in response to fasting and glucose in obese mice [0.03%]
肥胖小鼠在饥饿和葡萄糖刺激下，下丘脑Fto表达受损
N J Poritsanos,P S Lew,J Fischer et al.
N J Poritsanos et al.
Objective: Recent genome-wide association studies have identified a strong association between obesity and common variants in the fat mass and obesity associated (FTO) gene. FTO has been detected in the hypothalamus, but ...
Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women [0.03%]
反式脂肪摄入对超重绝经后妇女腹部和肝脏脂肪沉积及血脂水平影响的随机试验
N T Bendsen,E Chabanova,H S Thomsen et al.
N T Bendsen et al.
Background: Intake of industrially produced trans fatty acids (TFAs) is, according to observational studies, associated with an increased risk of cardiovascular disease, but the causal mechanisms have not been fully eluci...
Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue [0.03%]
短期和长期糖皮质激素治疗可增强人体皮下脂肪组织的胰岛素信号转导
L L Gathercole,S A Morgan,I J Bujalska et al.
L L Gathercole et al.
Background: Endogenous or exogenous glucocorticoid (GC) excess (Cushing's syndrome) is characterized by increased adiposity and insulin resistance. Although GCs cause global insulin resistance in vivo, we have previously ...
Abdominal adiposity depots are correlates of adverse cardiometabolic risk factors in Caucasian and African-American adults [0.03%]
waist周长与不良的心代谢危险因素在白人和非裔美国成人中相关性研究
R L Newton Jr,C Bouchard,G Bray et al.
R L Newton Jr et al.
Objective: Accumulation of adipose tissue is associated with cardiometabolic risks. Although visceral adipose tissue (VAT) has been strongly implicated in this relationship, there is still some debate regarding the contri...
Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat [0.03%]
DahlS.Z-Lepr(fa)/Lepr(fa)大鼠代谢综合征动物模型的表征研究
T Hattori,T Murase,M Ohtake et al.
T Hattori et al.
Objective: The DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rat strain was established from a cross between Dahl salt-sensitive rats and Zucker fatty (fa/fa) rats, the latter of which harbor a missense mutation in the leptin rece...